Histamine modulators, more commonly referred to as antihistamines, have been commonly used in the USA for over half a century. Many of the dangerous side effects of these medications have been minimized due to the development of more advanced formulations with the removal of the more dangerous medications from the US market by the FDA. Knowledge of the potential side effect profiles of the antihistamines is necessary for any provider who is either prescribing or administering these medications. Those negative side effect profiles include the effects on the cardiac system and the central nervous system. In addition, providers must know the effects that occur with the extremes of age and during pregnancy. Potential metabolic effects are also important aspects that must be considered when dealing with antihistamines. Remarkably, only one of the antihistamines has been assigned a boxed warning by the FDA.
KeywordsMigraine Histamine Warfarin Theophylline Cimetidine
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