Skip to main content
SpringerLink
Log in

Asthma and COPD Agents

  • Chapter
  • First Online:
Essentials of Pharmacology for Anesthesia, Pain Medicine, and Critical Care

  • 4725 Accesses

Abstract

Asthma and chronic obstructive pulmonary disease (COPD) are disorders of airway inflammation that are characterized by airflow obstruction. These disease entities demonstrate similar spirometric characteristics including FEV1/FVC <70 % and FEV1 <80 %, with asthma demonstrating reversibility of obstruction with bronchodilator therapy [1, 2]. There is much overlap in the pharmacologic management between asthma and COPD. In both diseases, acute attacks may be treated with inhaled and intravenous β2 agonists, inhaled anticholinergics, and systemic corticosteroids, while chronic management can be accomplished with inhaled agents (short- and long-acting β2 agonists, anticholinergics, or glucocorticoids) or methylxanthines. Chronic management of asthmatic patients can also include mast cell stabilizers, leukotriene modifiers, and immunomodulators, while that of COPD patients may include PDE-4 inhibitors. A brief summary of the impact of anesthetic agents on the patient with asthma is included.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Rennard I. Chronic obstructive pulmonary disease: definition, clinical manifestations, diagnosis, and staging. UptoDate Online. 2013.

    Google Scholar 

  2. Centers for Disease Control and Prevention. Chronic obstructive pulmonary disease among adults – United States, 2011. MMWR Morb Mortal Wkly Rep 2012;61:938.

    Google Scholar 

  3. Miniño AM, Murphy SL, Xu J, Kochanek KD. Deaths: final data for 2008. Natl Vital Stat Rep. 2011;59:1.

    Google Scholar 

  4. Sutherland ER, Martin RJ. Airway inflammation in chronic obstructive pulmonary disease: comparisons with asthma. J Allergy Clin Immunol. 2003;112(5):819.

    Article  PubMed  Google Scholar 

  5. National Asthma Education and Prevention Program: Clinical Practice Guidelines. Expert Panel Report 3. “Guidelines for the Diagnosis and Management of Asthma.” National Institutes of Health: National Heart, Lung, and Blood Institute. August 2007.

    Google Scholar 

  6. Barreiro TJ, Perillo I. An approach to interpreting spirometry. Am Fam Physician. 2004;69(5):1107–15. http://www.aafp.org/afp/2004/0301/p1107.html.

    PubMed  Google Scholar 

  7. Sethi S, Murphy TF. Infection in the pathogenesis and course of chronic obstructive pulmonary disease. N Engl J Med. 2008;359:2355.

    Article  CAS  PubMed  Google Scholar 

  8. Tucker J, Fanta CH. Integrative inflammation pharmacology: asthma. In: Golan DE, Tashjian AH, Armstrong E, Galanter JM, Armstrong AW, Arnaout RA, Rose HS, editors. Principles of pharmacology: the pathophysiologic basis of drug therapy. Philadelphia: Lippincott Williams & Wilkins; 2004. p. 699–711.

    Google Scholar 

  9. Woods BD, Sladen RN. Perioperative considerations for the patient with asthma and bronchospasm. Br J Anaesth. 2009;103 Suppl 1:i57–65.

    Article  PubMed  Google Scholar 

  10. Looseley A. Management of bronchospasm during general anaesthesia. Clinical Overview Articles. Update in Anaesthesia. 2011. p. 17–21. http://update.anaesthesiologists.org/…/Bronchospasm_during_anaesthesia_Update_2011.pdf.

  11. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: Revised 2011. Global Initiative for Chronic Obstructive Lung Disease (GOLD). www.goldcopd.org.

  12. American Academy of Allergy and Immunology. http://www.aaaai.org/conditions-and-treatments/treatments/drug-guide. 1 Dec 2012.

  13. Ogbru O, et al. RxList: The Internet Drug Index.”WebMD. Accessed July 22, 2013. www.rxlist.com.

  14. Fanta CH. Asthma. N Engl J Med. 2009;360:1002–14.

    Article  CAS  PubMed  Google Scholar 

  15. Nelson HS, Weiss ST, Bleecker ER, Yancey SW, Dorinsky PM, Smart Study Group. The salmeterol multicenter asthma research trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest. 2006;129(1):15–26.

    Article  CAS  PubMed  Google Scholar 

  16. Fanta CH. Treatment of acute exacerbations of asthma in adults. Table 1. UpToDate Online. 2012.

    Google Scholar 

  17. Xolair® Omalizumab. http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/omalgen062003LB.pdf. 23 Mar 2013.

  18. Yao FF. Asthma and chronic obstructive pulmonary disease. In: Yao FF, Malhotra V, Fontes ML, editors. Yao & Artusio’s anesthesiology: problem-oriented patient management. 6th edn. Philadelphia: Lippincott Williams & Wilkins; 2008. p 1–28.

    Google Scholar 

  19. Eames WO, Rooke GA, Wu RS, Bishop MJ. Comparison of the effects of etomidate, propofol, and thiopental on respiratory resistance following tracheal intubation. Anesthesiology. 1996;84:1307–11.

    Article  CAS  PubMed  Google Scholar 

  20. Pizov R, Brown RH, Weiss YS, Baranov D, Hennes H, Baker S, Hirshman CA. Wheezing during induction of general anesthesia in patients with and without asthma. A randomized, blind trial. Anesthesiology. 1995;82:1111–6.

    Article  CAS  PubMed  Google Scholar 

  21. Mazzeo AJ, Chen EY, Bosnjak ZJ, Coon RL, Kampine JP. Differential effects of desflurane and halothane on peripheral airway smooth muscle. Br J Anaes. 1996;76:841–6.

    Article  CAS  Google Scholar 

  22. Goff MJ, Arain SR, Ficke DJ, Uhrich TD, Ebert TJ. Absence of bronchodilation during desflurane anesthesia. Anesthesiology. 2000;93:404–8.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA

    Alexis Appelstein DO & Mabel Chung MD

Authors
  1. Alexis Appelstein DO
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mabel Chung MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mabel Chung MD .

Editor information

Editors and Affiliations

  1. Departments of Anesthesiology and Pharmacology, LSU Health Sciences Center, New Orleans, Louisiana, USA

    Alan David Kaye

  2. Department of Pharmacy Practice, Thomas J. Long School of Pharmacy and Health Sciences, Stockton, California, USA

    Adam M. Kaye

  3. Center for Perioperative Management and Medical Informatics, Brigham and Women’s Hospital, Boston, Massachusetts, USA

    Richard D. Urman

Chemical Structures

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer Science+Business Media New York

About this chapter

Cite this chapter

Appelstein, A., Chung, M. (2015). Asthma and COPD Agents. In: Kaye, A., Kaye, A., Urman, R. (eds) Essentials of Pharmacology for Anesthesia, Pain Medicine, and Critical Care. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8948-1_18

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-8948-1_18

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-8947-4

  • Online ISBN: 978-1-4614-8948-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation