Muscle relaxants were first used on poisonous darts by South American Indians during hunting, according to accounts found in the court of King Ferdinand and Queen Isabella. It took several hundred years until their therapeutic potential was realized in the medical setting. Tubocurarine, the first muscle relaxant used clinically, often produced hypotension and tachycardia through histamine release. Today, we have sophisticated neuromuscular blockers (NMBs) that keep the patient paralyzed providing ideal surgical conditions, facilitating intubation and artificial ventilation, with minimal changes to vital signs.
KeywordsHistamine Halothane Sevoflurane Acetylcholinesterase Tetanus
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