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Abstract

Benzodiazepines have gained growing popularity as its physiology and pharmacology have become better understood, allowing for drugs of varying potency and duration of action to be developed for a wide range of clinical applications. Muscle relaxants are a diverse group of drugs designed to treat pain related to muscle spasms or spasticity. While benzodiazepines and muscle relaxants are generally well tolerated, there are serious side effects and toxicity that practitioners must be aware of, as well as abuse potential.

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References

  1. Griffin CE, Kaye AM, Bueno FR, Kaye AD. Benzodiazepine pharmacology and central nervous system-mediated effects. Oschner Clin J. 2013;13(2):214–23.

    Google Scholar 

  2. Sieghart W. Pharmacology of benzodiazepine receptors: an update. J Psychiatry Neurosci. 1994;19(1):24–9.

    CAS  PubMed Central  PubMed  Google Scholar 

  3. Kaye AD, Gayle K, Kaye AM. Pharmacological agents in moderate and deep sedation. In: Kaye AD, Urman R, editors. Moderate and deep sedation. New York: Cambridge Press; 2011. p. 8–32.

    Google Scholar 

  4. American Geriatrics Society. Beers criteria update expert panel. American geriatrics society updated beers criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2012;60:616–31.

    Article  Google Scholar 

  5. World Health Organization. Programme on substance abuse: rational use of benzodiazepines. World Health Organization. 1996.

    Google Scholar 

  6. Stout T, Kaye AD, Kaye AM. Muscle relaxants and antispasticity drugs. In: Manchikanti L, editor. In: Foundations of interventional pain management and pain medicine ASIPP publishing. Paducah, KY. Chapter VI–10, 607–14.

    Google Scholar 

  7. Zafonte R, Lombard L, Elovic E. Antispasticity medications: uses and limitations of enteral therapy. Am J Phys Med Rehabil. 2004;83:S50–8.

    Article  PubMed  Google Scholar 

  8. Onur M, Benzon HT. Muscle relaxants. In: Essentials of pain medicine and regional anesthesia. New York: Churchill Livingstone; 1999. p. 78–82.

    Google Scholar 

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Correspondence to Joyce C. Lo MD .

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Chemical Structures

Chemical Structures

Chemical Structure 10.1
figure 1

Baclofen

Chemical Structure 10.2
figure 2

Cyclobenzaprine hydrochloride

Chemical Structure 10.3
figure 3

Dantrolene sodium

Chemical Structure 10.4
figure 4

Tizanidine

Chemical Structure 10.5
figure 5

Orphenadrine citrate

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Lo, J.C., Kaye, A.D. (2015). Benzodiazepines and Muscle Relaxants. In: Kaye, A., Kaye, A., Urman, R. (eds) Essentials of Pharmacology for Anesthesia, Pain Medicine, and Critical Care. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8948-1_10

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  • DOI: https://doi.org/10.1007/978-1-4614-8948-1_10

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  • Publisher Name: Springer, New York, NY

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  • Online ISBN: 978-1-4614-8948-1

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