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Neuromuscular/Chemodenervation

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Part of the book series: Musculoskeletal Medicine ((MUM))

Abstract

Spasticity is a velocity-dependent increase in a muscle’s resistance to passive range of motion and is caused by the loss of supraspinal inhibition of the muscle stretch reflex. Spasticity can be both functionally useful and functionally detrimental. Therefore, how we manage and treat it can have a significant impact on the lives of patients with upper motor neuron disorders such as stroke, traumatic or anoxic brain injury, and spinal cord injury. Dystonia is a neurological movement disorder characterized by involuntary motor contractions resulting in abnormal posturing and twisting motions. Both spasticity and dystonia often result in major impairments with activities of daily living, ambulation, and independence while causing pain and discomfort. Severe cases of spasticity leave patients vulnerable to contractures and skin breakdown.

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References

  1. Curtiss HM, Finnoff JT, Peck E, Hollman J, Muir J, Smith J. Accuracy of ultrasound-guided and palpation-guided knee injections by an experienced and less-experienced injector using a superolateral approach: a cadaveric study. PM R. 2011;3(6):507–15.

    Article  PubMed  Google Scholar 

  2. Sabeti-Aschraf M, Lemmerhofer B, Lang S, Schmidt M, Funovics PT, Ziai P, Frenzel S, Kolb A, Graf A, Schueller-Weidekamm C. Ultrasound guidance improves the accuracy of the acromioclavicular joint infiltration: a prospective randomized study. Knee Surg Sports Traumatol Arthrosc. 2011;19(2):292–5.

    Article  PubMed  Google Scholar 

  3. Wisniewski SJ, Smith J, Patterson DG, Carmichael SW, Pawlina W. Ultrasound-guided versus nonguided tibiotalar joint and sinus tarsi injections: a cadaveric study. PM R. 2010;2(4):277–81.

    Article  PubMed  Google Scholar 

  4. Haig AJ, Goodmurphy CW, Harris AR, Ruiz AP, Etemad J. The accuracy of needle placement in lower-limb muscles: a blinded study. Arch Phys Med Rehabil. 2003;84(6):877–82.

    Article  PubMed  Google Scholar 

  5. Chin TY, Nattrass GR, Selber P, Graham HK. Accuracy of intramuscular injection of botulinum toxin A in juvenile cerebral palsy: a comparison between manual needle placement and placement guided by electrical stimulation. J Pediatr Orthop. 2005;25(3):286–91.

    Article  PubMed  Google Scholar 

  6. Lim ECH, Seet RCS. Botulinum toxin: description of injection techniques and examination of controversies surrounding toxin diffusion. Acta Neurol Scand. 2008;117(2):73–84.

    PubMed  CAS  Google Scholar 

  7. Gooch JL, Patton CP. Combining botulinum toxin and phenol to manage spasticity in children. Arch Phys Med Rehabil. 2004;85(7): 1121–4.

    Article  PubMed  Google Scholar 

  8. Stengel G, Bee EK. Antibody-induced secondary treatment failure in a patient treated with botulinum toxin type A for glabellar frown lines. Clin Interv Aging. 2011;6:281–4. doi:10.2147/CIA.S18997. Epub 2011 Nov 9.

    Article  PubMed  CAS  Google Scholar 

  9. LLC. Xeomin [package insert]. Greensboro: Merz Pharmaceuticals; 2011.

    Google Scholar 

  10. Lim EC, Seet RC. Use of botulinum toxin in the neurology clinic. Nat Rev Neurol. 2010;6(11):624–36.

    Article  PubMed  CAS  Google Scholar 

  11. Henzel MK, Munin MC, Niyonkuru C, Skidmore ER, Weber DJ, Zafonte RD. Comparison of surface and ultrasound localization to identify forearm flexor muscles for botulinum toxin injections. PM R. 2010;2(7):642–6.

    Article  PubMed  Google Scholar 

  12. Mayer NH, Esquenazi A. Managing upper motor neuron muscle overactivity. In: Zasler ND, Katz DI, Zafonte RD, editors. Brain injury medicine. 2nd ed. New York: Demos Medical Publishing; 2013. p. 821–49.

    Google Scholar 

  13. Bickerton LE, Agur AM, Ashby P. Flexor digitorum superficialis: locations of individual muscle bellies for botulinum toxin injections. Muscle Nerve. 1997;20(8):1041–3.

    Article  PubMed  CAS  Google Scholar 

  14. Munin MC, Navalgund BK, Levitt DA, Breisinger TP, Zafonte RD. Novel approach to the application of botulinum toxin to the flexor digitorum superficialis muscle in acquired brain injury. Brain Inj. 2004;18(4):403–7.

    Article  PubMed  Google Scholar 

  15. Willenborg MJ, Shilt JS, Smith BP, Estrada RL, Castle JA, Koman LA. Technique for iliopsoas ultrasound-guided active electromyography-directed botulinum a toxin injection in cerebral palsy. J Pediatr Orthop. 2002;22(2):165–8.

    PubMed  Google Scholar 

  16. Westhoff B, Seller K, Wild A, Jaeger M, Krauspe R. Ultrasound-guided botulinum toxin injection technique for the iliopsoas muscle. Dev Med Child Neurol. 2003;45(12):829–32.

    Article  PubMed  Google Scholar 

  17. Van Campenhout A, Hubens G, Fagard K, Molenaers G. Localization of motor nerve branches of the human psoas muscle. Muscle Nerve. 2010;42(2):202–7.

    Article  PubMed  Google Scholar 

  18. Van Campenhout A, Molenaers G. Localization of the motor endplate zone in human skeletal muscles of the lower limb: anatomical guidelines for injection with botulinum toxin. Dev Med Child Neurol. 2011;53(2):108–19.

    Article  PubMed  Google Scholar 

  19. Ward AB. Botulinum toxin type A treatment of hip and thigh spasticity: a technique for injection of psoas major muscle. Eur J Neurol. 1999;6 suppl 4:S91–3.

    Article  Google Scholar 

  20. Takai Y, Katsumata Y, Kawakami Y, Kanehisa H, Fukunaga T. Ultrasound method for estimating the cross sectional area of the psoas major muscle. Med Sci Sports Exerc. 2011;43(10):2000–4.

    Article  PubMed  Google Scholar 

  21. Won SJ, Kim JY, Yoon JS, Kim SJ. Ultrasonographic evaluation of needle electromyography insertion into the tibialis posterior using a posterior approach. Arch Phys Med Rehabil. 2011;92(11):1921–3.

    Article  PubMed  Google Scholar 

  22. Oddy MJ, Brown C, Mistry R, Eastwood DM. Botulinum toxin injection site localization for the tibialis posterior muscle. J Pediatr Orthop B. 2006;15(6):414–7.

    Article  PubMed  Google Scholar 

  23. Yang SN, Lee SH, Kwon HK. Needle electrode insertion into the tibialis posterior: a comparison of the anterior and posterior approaches. Arch Phys Med Rehabil. 2008;89(9):1816–8.

    Article  PubMed  Google Scholar 

  24. Rha DW, Im SH, Lee SC, Kim SK. Needle insertion into the tibialis posterior: ultrasonographic evaluation of an anterior approach. Arch Phys Med Rehabil. 2010;91(2):283–7.

    Article  PubMed  Google Scholar 

  25. Simpson DM, Blitzer A, Brashear A, et al. Assessment: botulinum neurotoxin for the treatment of movement disorders (an evidence-based review). Neurology. 2008;70(19):1699–706.

    Article  PubMed  CAS  Google Scholar 

  26. Tsui JC, Jon Stoessl A, Eisen A, Calne S, Calne D. Double-blind study of botulinum toxin in spasmodic torticollis. The Lancet. 1986;328(8501):245–7.

    Article  Google Scholar 

  27. Hefter HKA, Müngersdorf M, Paus S, Stenner A, Jost W, Dysport Cervical Dystonia Study Group. A botulinum toxin A treatment algorithm for de novo management of torticollis and laterocollis. BMJ Open. 2011;1(2):e000196.

    Article  PubMed  Google Scholar 

  28. Lee IH, Yoon YC, Sung DH, Kwon JW, Jung JY. Initial experience with imaging-guided intramuscular botulinum toxin injection in patients with idiopathic cervical dystonia. AJR Am J Roentgenol. 2009;192(4):996–1001.

    Article  PubMed  Google Scholar 

  29. Consky ES, Lang AE. Clinical assessments of patients with cervical dystonia. In: Jankovic J, Hallett M, editors. Therapy with botulinum toxin. New York: Marcel Dekker, Inc; 1994. p. 211–37.

    Google Scholar 

  30. Kim H, Lee Y, Weiner D, Kaye R, Cahill AM, Yudkoff M. Botulinum toxin type a injections to salivary glands: combination with single event multilevel chemoneurolysis in 2 children with severe spastic quadriplegic cerebral palsy. Arch Phys Med Rehabil. 2006;87(1):141–4.

    Article  PubMed  Google Scholar 

  31. Walker FO. Botulinum toxin therapy for cervical dystonia. Phys Med Rehabil Clin N Am. 2003;14(4):749–66.

    Article  PubMed  Google Scholar 

  32. Nordgarden H, Osterhus I, Moystad A, et al. Drooling: are botulinum toxin injections into the major salivary glands a good treatment option? J Child Neurol. 2011;27:458–64.

    Article  PubMed  Google Scholar 

  33. Pena AH, Cahill AM, Gonzalez L, Baskin KM, Kim H, Towbin RB. Botulinum toxin A injection of salivary glands in children with drooling and chronic aspiration. J Vasc Interv Radiol. 2009;20(3):368–73.

    Article  PubMed  Google Scholar 

  34. Scheffer AR, Erasmus C, van Hulst K, van Limbeek J, Jongerius PH, van den Hoogen FJ. Efficacy and duration of botulinum toxin treatment for drooling in 131 children. Arch Otolaryngol Head Neck Surg. 2010;136(9):873–7.

    Article  PubMed  Google Scholar 

  35. Breheret R, Bizon A, Jeufroy C, Laccourreye L. Ultrasound-guided botulinum toxin injections for treatment of drooling. Eur Ann Otorhinolaryngol Head Neck Dis. 2011;128(5):224–9.

    Article  PubMed  CAS  Google Scholar 

  36. Moller E, Karlsborg M, Bardow A, Lykkeaa J, Nissen FH, Bakke M. Treatment of severe drooling with botulinum toxin in amyotrophic lateral sclerosis and Parkinson’s disease: efficacy and possible mechanisms. Acta Odontol Scand. 2011;69(3):151–7.

    Article  PubMed  CAS  Google Scholar 

  37. Wu KP, Ke JY, Chen CY, Chen CL, Chou MY, Pei YC. Botulinum toxin type A on oral health in treating sialorrhea in children with cerebral palsy: a randomized, double-blind, placebo-controlled study. J Child Neurol. 2011;26(7):838–43.

    Article  PubMed  Google Scholar 

  38. Khan WU, Campisi P, Nadarajah S, et al. Botulinum toxin A for treatment of sialorrhea in children: an effective, minimally invasive approach. Arch Otolaryngol Head Neck Surg. 2011;137(4):339–44.

    Article  PubMed  Google Scholar 

  39. Dogu O, Apaydin D, Sevim S, Talas DU, Aral M. Ultrasound-guided versus ‘blind’ intraparotid injections of botulinum toxin-A for the treatment of sialorrhoea in patients with Parkinson’s disease. Clin Neurol Neurosurg. 2004;106(2):93–6.

    Article  PubMed  Google Scholar 

  40. Erasmus CE, Van Hulst K, Van Den Hoogen FJ, et al. Thickened saliva after effective management of drooling with botulinum toxin A. Dev Med Child Neurol. 2010;52(6):e114–8.

    Article  PubMed  Google Scholar 

  41. Sriskandan N, Moody A, Howlett DC. Ultrasound-guided submandibular gland injection of botulinum toxin for hypersalivation in cerebral palsy. Br J Oral Maxillofac Surg. 2010;48(1):58–60.

    Article  PubMed  Google Scholar 

  42. Marina MB, Sani A, Hamzaini AH, Hamidon BB. Ultrasound-guided botulinum toxin A injection: an alternative treatment for dribbling. J Laryngol Otol. 2008;122(6):609–14.

    Article  PubMed  CAS  Google Scholar 

  43. Reid SM, Johnstone BR, Westbury C, Rawicki B, Reddihough DS. Randomized trial of botulinum toxin injections into the salivary glands to reduce drooling in children with neurological disorders. Dev Med Child Neurol. 2008;50(2):123–8.

    PubMed  CAS  Google Scholar 

  44. Wilken B, Aslami B, Backes H. Successful treatment of drooling in children with neurological disorders with botulinum toxin A or B. Neuropediatrics. 2008;39(4):200–4.

    Article  PubMed  CAS  Google Scholar 

  45. Gerlinger I, Szalai G, Hollody K, Nemeth A. Ultrasound-guided, intraglandular injection of botulinum toxin A in children suffering from excessive salivation. J Laryngol Otol. 2007;121(10):947–51.

    Article  PubMed  CAS  Google Scholar 

  46. Shetty S, Dawes P, Ruske D, Al-qudah M, Lyons B. Botulinum toxin type-A (Botox-A) injections for treatment of sialorrhoea in adults: a New Zealand study. N Z Med J. 2006;119(1240):U2129.

    PubMed  Google Scholar 

  47. Hassin-Baer S, Scheuer E, Buchman AS, Jacobson I, Ben-Zeev B. Botulinum toxin injections for children with excessive drooling. J Child Neurol. 2005;20(2):120–3.

    Article  PubMed  Google Scholar 

  48. Eid N, Ito Y, Otsuki Y. Submandibular gland botulinum toxin injections for drooling: the safe and risky zones. Surg Radiol Anat. 2011;33(5):465–6.

    Article  PubMed  Google Scholar 

  49. Jongerius PH, van den Hoogen FJ, van Limbeek J, Gabreels FJ, van Hulst K, Rotteveel JJ. Effect of botulinum toxin in the treatment of drooling: a controlled clinical trial. Pediatrics. 2004;114(3):620–7.

    Article  PubMed  Google Scholar 

  50. Lee JH, Lee BN, Kwon SO, Chung RH, Han SH. Anatomical localization of submandibular gland for botulinum toxin injection. Surg Radiol Anat. 2010;32(10):945–9.

    Article  PubMed  CAS  Google Scholar 

  51. Esquenazi A. Botulinum toxin in the treatment of lower limb spasticity. In: Brashear A, Elovic E, editors. Spasticity diagnosis and management. New York: Demos Medical Publishing; 2011. p. 119–29.

    Google Scholar 

  52. Guidubaldi A, Fasano A, Ialongo T, Piano C, Pompili M, Mascianà R, Siciliani L, Sabatelli M, Bentivoglio AR. Botulinum toxin A versus B in sialorrhea: a prospective, randomized, double-blind, crossover pilot study in patients with amyotrophic lateral sclerosis or Parkinson’s disease. Mov Disord. 2011;26(2):313–9. doi:10.1002/mds.23473. Epub 2011 Jan 21.

    Article  PubMed  Google Scholar 

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Correspondence to Sarah Khan DO .

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Khan, S., Lin, E., Kirschner, J.S. (2014). Neuromuscular/Chemodenervation. In: Spinner, D., Kirschner, J., Herrera, J. (eds) Atlas of Ultrasound Guided Musculoskeletal Injections. Musculoskeletal Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8936-8_9

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  • DOI: https://doi.org/10.1007/978-1-4614-8936-8_9

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