The Diagnosis of Sarcoidosis

  • Marc A. JudsonEmail author
Part of the Respiratory Medicine book series (RM, volume 17)


The diagnosis of sarcoidosis is never completely secure. The diagnosis can, rarely, be made on clinical grounds without biopsy confirmation if the clinical presentation is very specific for the disease. Otherwise, histological confirmation of granulomatous inflammation is required. However, identification of granulomatous inflammation is inadequate to make the diagnosis of sarcoidosis as this histological pattern is associated with many alternative diseases. Therefore, a diligent effort must be undertaken to exclude such diseases. This effort includes obtaining a detailed medical history as well as careful examination of the biopsied material. Because sarcoidosis is a multisystem granulomatous disease of unknown cause, additional efforts must be made to identify involvement in at least two organs to confirm the diagnosis. This chapter outlines the approach and potential pitfalls in establishing a diagnosis of sarcoidosis.


Sarcoidosis Diagnosis Etiology Biopsy Pathology 


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© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Division of Pulmonary and Critical Care Medicine, Department of MedicineAlbany Medical CollegeAlbanyUSA

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