Vaccines Against Leishmaniasis

  • Awanish Kumar
Chapter
Part of the SpringerBriefs in Immunology book series (BRIEFSIMMUN, volume 3)

Abstract

The development of a vaccine against leishmaniasis is a long term goal in both human and veterinary medicine. In the past decade, various subunit and DNA antigens have been identified as potential vaccine candidates in experimental animals but none have so far been approved for human use. To date there is no vaccine available against VL in routine use anywhere in the world. However, there is consensus that in the long term, vaccines ought to become a major tool in the control of this group of diseases. Unfortunately, the development of vaccines has been hampered by significant antigenic diversity and the fact that the parasites have a digenetic life cycle. Although a great number of antigens have been tested for protection against the cutaneous disease with in vitro cell or mouse models, no effective vaccine against human kala-azar is yet available. Though, the solid immunity observed following cure of kala-azar has suggested that the vaccination to prevent leishmaniasis is within the reach of conventional immunization methods, only few reports in literature deal with vaccines viz., FML, FML-QuilA Saponin against canine VL (Santos et al. 2002). Immune mechanisms involved in VL and various vaccines candidates evaluated in experimental models for VL has been extensively reviewed by Modabber (1995), Handman (2001), Scott (2003), Ravindran and Ali (2004), Goto and Lindoso (2004), Nyame et al. (2004), Kaye et al. (2004), Wilson et al. (2005), Garg and Dube (2006).

Keywords

Tuberculosis Polypeptide Cyclosporin Dinucleotide Glucan 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Awanish Kumar
    • 1
  1. 1.School of Life SciencesJawaharlal UniversityNew DelhiIndia

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