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Risk Compensation in Response to HIV Prevention

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Biomedical Advances in HIV Prevention

Abstract

The success of emerging and available biomedical HIV prevention strategies is dependent, in part, on behavioral responses to these technologies. Of concern is how HIV risk-taking behavior may change with the availability of new biomedical technologies. In this chapter, we: (a) review the evidence for risk compensation in response to male circumcision, antiretroviral-based prevention, and HIV vaccines and (b) offer direction on the next steps for studying risk compensation related to biomedical technology. In our review of the literature, we find mixed evidence for the presence of risk compensation. In trials assessing the efficacy of biomedical HIV prevention technology, most report that sexual risk-taking decreased over the course of the trial. Yet, in studies outside of randomized controlled trials, we do find evidence for the presence of risk compensation in the context of prevention technologies. Many studies reporting on risk compensation-related findings present it as a secondary outcome and do not use methodological designs ideal for accurately assessing risk compensation. Based on the currently available literature, there is urgent need for longitudinal cohort studies for investigating the influence of risk compensation during the use of biomedical HIV prevention technologies in real-world settings.

This project was supported in part by National Institute of Mental Health grant R01 MH094230 and a grant from the Bill and Melinda Gates Foundation to FHI360 to support the Male Circumcision Consortium (grant #47394).

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References

  1. Eaton LA, Kalichman S. Risk compensation in HIV prevention: implications for vaccines, microbicides, and other biomedical HIV prevention technologies. Curr HIV/AIDS Rep. 2007 Dec;4(4):165–72.

    Article  PubMed  Google Scholar 

  2. Wilde GJS. Target risk: dealing with the danger of death, disease and damage in everyday decisions. Toronto: PDE Publications; 1994.

    Google Scholar 

  3. World Health Organization, Joint United Nations Programme on HIV/AIDS. New data on male circumcision and HIV prevention: policy and programme implications. 2007. http://libdoc.who.int/publications/2007/9789241595988_eng.pdf. Accessed September 21, 2012.

  4. Bailey RC, Moses S, Parker CB, Agot K, Maclean I, Krieger JN, et al. Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial. Lancet. 2007 Feb 24;369(9562):643–56.

    Article  PubMed  Google Scholar 

  5. Gray RH, Kigozi G, Serwadda D, Makumbi F, Watya S, Nalugoda F, et al. Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial. Lancet. 2007 Feb 24;369(9562):657–66.

    Article  PubMed  Google Scholar 

  6. Auvert B, Taljaard D, Lagarde E, Sobngwi-Tambekou J, Sitta R, Puren A. Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 Trial. PLoS Med. 2005 Nov;2(11):e298.

    Article  PubMed  Google Scholar 

  7. Bollinger LA, Stover J, Musuka G, Fidzani B, Moeti T, Busang L. The cost and impact of male circumcision on HIV/AIDS in Botswana. J Int AIDS Soc. 2009;12:7.

    Article  PubMed  Google Scholar 

  8. Gray RH, Li X, Kigozi G, Serwadda D, Nalugoda F, Watya S, et al. The impact of male circumcision on HIV incidence and cost per infection prevented: a stochastic simulation model from Rakai, Uganda. AIDS (London, England). 2007 Apr 23;21(7):845–50.

    Article  PubMed  Google Scholar 

  9. Nagelkerke NJ, Moses S, de Vlas SJ, Bailey RC. Modelling the public health impact of male circumcision for HIV prevention in high prevalence areas in Africa. BMC Infect Dis. 2007;7:16.

    Article  PubMed  Google Scholar 

  10. UNAIDS/WHO/SACEMA Expert Group on Modelling the Impact and Cost of Male Circumcision for HIV Prevention. Male circumcision for HIV prevention in high HIV prevalence settings: what can mathematical modelling contribute to informed decision making? PLoS Med. 2009 Sep;6(9):e1000109.

    Article  Google Scholar 

  11. Williams BG, Lloyd-Smith JO, Gouws E, Hankins C, Getz WM, Hargrove J, et al. The potential impact of male circumcision on HIV in Sub-Saharan Africa. PLoS Med. 2006 Jul;3(7):e262.

    Article  PubMed  Google Scholar 

  12. Weiss HA, Dickson KE, Agot K, Hankins CA. Male circumcision for HIV prevention: current research and programmatic issues. AIDS (London, England). 2010 Oct;24 Suppl 4:S61–9.

    Article  PubMed  Google Scholar 

  13. Kahn JG, Marseille E, Auvert B. Cost-effectiveness of male circumcision for HIV prevention in a South African setting. PLoS Med. 2006 Dec;3(12):e517.

    Article  PubMed  Google Scholar 

  14. Westercamp N, Bailey RC. Acceptability of male circumcision for prevention of HIV/AIDS in sub-Saharan Africa: a review. AIDS Behav. 2007 May;11(3):341–55.

    Article  PubMed  CAS  Google Scholar 

  15. de Bruyn G, Martinson NA, Gray GE. Male circumcision for HIV prevention: developments from sub-Saharan Africa. Expert Rev Anti Infect Ther. 2010 Jan;8(1):23–31.

    Article  PubMed  Google Scholar 

  16. Hankins C, Forsythe S, Njeuhmeli E. Voluntary medical male circumcision: an introduction to the cost, impact, and challenges of accelerated scaling up. PLoS Med. 2011 Nov;8(11):e1001127.

    Article  PubMed  Google Scholar 

  17. Cassell MM, Halperin DT, Shelton JD, Stanton D. Risk compensation: the Achilles’ heel of innovations in HIV prevention? BMJ (Clinical research ed). 2006 Mar 11;332(7541):605–7.

    Article  PubMed  Google Scholar 

  18. Kalichman S, Eaton L, Pinkerton S. Circumcision for HIV prevention: failure to fully account for behavioral risk compensation. PLoS Med. 2007 Mar 27;4(3):e138; author reply e46.

    Google Scholar 

  19. White RG, Glynn JR, Orroth KK, Freeman EE, Bakker R, Weiss HA, et al. Male circumcision for HIV prevention in sub-Saharan Africa: who, what and when? AIDS (London, England). 2008 Sep 12;22(14):1841–50.

    Google Scholar 

  20. Eaton LA, Cain DN, Agrawal A, Jooste S, Udemans N, Kalichman SC. The influence of male circumcision for HIV prevention on sexual behaviour among traditionally circumcised men in Cape Town, South Africa. Int J STD AIDS. 2011 Nov;22(11):674–9.

    Article  PubMed  CAS  Google Scholar 

  21. Maughan-Brown B, Venkataramani AS. Learning that circumcision is protective against HIV: risk compensation among men and women in Cape Town, South Africa. PLoS One. 2012;7(7):e40753.

    Article  PubMed  CAS  Google Scholar 

  22. Anderson J, Wilson D, Templeton DJ, Grulich A, Carter R, Kaldor J. Cost-effectiveness of adult circumcision in a resource-rich setting for HIV prevention among men who have 2 with men. J Infect Dis. 2009 Dec 15;200(12):1803–12.

    Article  PubMed  Google Scholar 

  23. Templeton DJ, Millett GA, Grulich AE. Male circumcision to reduce the risk of HIV and sexually transmitted infections among men who have sex with men. Curr Opin Infect Dis. 2010 Feb;23(1):45–52.

    Article  PubMed  Google Scholar 

  24. Wei C, Raymond HF, McFarland W, Buchbinder S, Fuchs JD. What is the potential impact of adult circumcision on the HIV epidemic among men who have sex with men in San Francisco? Sex Transm Dis. 2011 Apr;38(4):353–5.

    PubMed  Google Scholar 

  25. Alsallaq RA, Cash B, Weiss HA, Longini IM Jr, Omer SB, Wawer MJ, et al. Quantitative assessment of the role of male circumcision in HIV epidemiology at the population level. Epidemics. 2009 Sep;1(3):139–52.

    Article  PubMed  Google Scholar 

  26. Andersson KM, Owens DK, Paltiel AD. Scaling up circumcision programs in Southern Africa: the potential impact of gender disparities and changes in condom use behaviors on heterosexual HIV transmission. AIDS Behav. 2011 Jul;15(5):938–48.

    Article  PubMed  Google Scholar 

  27. Dushoff J, Patocs A, Shi CF. Modeling the population-level effects of male circumcision as an HIV-preventive measure: a gendered perspective. PLoS One. 2011;6(12):e28608.

    Article  PubMed  CAS  Google Scholar 

  28. Hallett TB, Alsallaq RA, Baeten JM, Weiss H, Celum C, Gray R, et al. Will circumcision provide even more protection from HIV to women and men? New estimates of the population impact of circumcision interventions. Sex Transm Infect. 2011 Mar;87(2):88–93.

    Article  PubMed  Google Scholar 

  29. Hallett TB, Singh K, Smith JA, White RG, Abu-Raddad LJ, Garnett GP. Understanding the impact of male circumcision interventions on the spread of HIV in southern Africa. PLoS One. 2008;3(5):e2212.

    Article  PubMed  Google Scholar 

  30. Njeuhmeli E, Forsythe S, Reed J, Opuni M, Bollinger L, Heard N, et al. Voluntary medical male circumcision: modeling the impact and cost of expanding male circumcision for HIV prevention in eastern and southern Africa. PLoS Med. 2011 Nov;8(11):e1001132.

    Article  PubMed  Google Scholar 

  31. Gray R, Kigozi G, Kong X, Ssempiija V, Makumbi F, Wattya S, et al. The effectiveness of male circumcision for HIV prevention and effects on risk behaviors in a posttrial follow-up study. AIDS (London, England). 2012 Mar 13;26(5):609–15.

    Article  PubMed  Google Scholar 

  32. Siegfried N, Muller M, Deeks JJ, Volmink J. Male circumcision for prevention of heterosexual acquisition of HIV in men. Cochrane Database Syst Rev (Online). 2009(2):CD003362.

    Google Scholar 

  33. Eaton L, Kalichman SC. Behavioral aspects of male circumcision for the prevention of HIV infection. Curr HIV/AIDS Rep. (Research Support, N.I.H., Extramural Review). 2009 Nov;6(4):187–93.

    Article  PubMed  Google Scholar 

  34. Mattson CL, Campbell RT, Bailey RC, Agot K, Ndinya-Achola JO, Moses S. Risk compensation is not associated with male circumcision in Kisumu, Kenya: a multi-faceted assessment of men enrolled in a randomized controlled trial. PLoS One. 2008;3(6):e2443.

    Google Scholar 

  35. Agot KE, Kiarie JN, Nguyen HQ, Odhiambo JO, Onyango TM, Weiss NS. Male circumcision in Siaya and Bondo Districts, Kenya: prospective cohort study to assess behavioral disinhibition following circumcision. J Acquir Immune Defic Syndr. 2007 Jan 1;44(1):66–70.

    Article  PubMed  Google Scholar 

  36. Wang AL, Duke W, Schmid GP. Print media reporting of male circumcision for preventing HIV infection in sub-Saharan Africa. Bull World Health Organ. 2009 Aug;87(8):595–603.

    Article  PubMed  Google Scholar 

  37. Communication for Change (C-Change) Project. Voluntary medical male circumcision communication guide for Nyanza Province. Nairobi, Kenya 2011.

    Google Scholar 

  38. Riess TH, Achieng MM, Otieno S, Ndinya-Achola JO, Bailey RC. “When I was circumcised I was taught certain things”: risk compensation and protective sexual behavior among circumcised men in Kisumu, Kenya. PLoS One. 2010;5(8):e12366.

    Article  PubMed  Google Scholar 

  39. Grund JM, Hennink MM. A qualitative study of sexual behavior change and risk compensation following adult male circumcision in urban Swaziland. AIDS Care. 2012;24(2):245–51.

    PubMed  Google Scholar 

  40. Wang Z, Lau JT, Gu J. Acceptability of circumcision among clients of female sex worker in Hong Kong. AIDS Behav. 2012 Nov 13;16(7):1836–45.

    Article  PubMed  Google Scholar 

  41. Gust DA, Kretsinger K, Pals SL, Gaul ZJ, Hefflefinger JD, Begley EB, et al. Male circumcision as an HIV prevention intervention in the U.S.: influence of health care providers and potential for risk compensation. Prev Med. 2011 Mar–Apr;52(3–4):270–3.

    PubMed  Google Scholar 

  42. Andersson N, Cockcroft A. Male circumcision, attitudes to HIV prevention and HIV status: a cross-sectional study in Botswana, Namibia and Swaziland. AIDS Care. 2012;24(3):301–9.

    Article  PubMed  Google Scholar 

  43. Lissouba P, Taljaard D, Rech D, Dermaux-Msimang V, Legeai C, Lewis D, et al. Adult male circumcision as an intervention against HIV: an operational study of uptake in a South African community (ANRS 12126). BMC Infect Dis. 2011;11:253.

    Article  PubMed  Google Scholar 

  44. Westercamp M, Agot KE, Ndinya-Achola J, Bailey RC. Circumcision preference among women and uncircumcised men prior to scale-up of male circumcision for HIV prevention in Kisumu, Kenya. AIDS Care. 2012;24(2):157–66.

    PubMed  Google Scholar 

  45. Bailey RC, Muga R, Poulussen R, Abicht H. The acceptability of male circumcision to reduce HIV infections in Nyanza Province, Kenya. AIDS Care. 2002 Feb;14(1):27–40.

    Article  PubMed  CAS  Google Scholar 

  46. Ngalande R, Levy J, Kapondo C, Bailey RC. Acceptability of male circumcision for prevention of HIV infection in Malawi. AIDS Behav. 2006;10(4):377–85.

    Article  PubMed  Google Scholar 

  47. Rain-Taljaard RC, Lagarde E, Taljaard DJ, Campbell C, MacPhail C, Williams B, et al. Potential for an intervention based on male circumcision in a South African town with high levels of HIV infection. AIDS Care. 2003 Jun;15(3):315–27.

    Article  PubMed  CAS  Google Scholar 

  48. Kelly A, Kupul M, Fitzgerald L, Aeno H, Neo J, Naketrumb R, et al. “Now we are in a different time; various bad diseases have come.” Understanding men’s acceptability of male circumcision for HIV prevention in a moderate prevalence setting. BMC Public Health. 2012;12:67.

    Article  PubMed  Google Scholar 

  49. Godlonton S, Munthali A, Thornton R. Behavioral Response to information? Circumcision, information, and HIV prevention. Bureau for Research and Economic Analysis of Development Working Paper no. 313; 2011.

    Google Scholar 

  50. Peltzer K, Simbayi L, Banyini M, Kekana Q. HIV risk reduction intervention among traditionally circumcised young men in South Africa: a cluster randomized control trial. J Assoc Nurses AIDS Care. 2011 Sep–Oct;22(5):397–406.

    Article  PubMed  Google Scholar 

  51. Brown JE, Micheni KD, Grant EM, Mwenda JM, Muthiri FM, Grant AR. Varieties of male circumcision: a study from Kenya. Sex Transm Dis. 2001 Oct;28(10):608–12.

    Article  PubMed  CAS  Google Scholar 

  52. Maughan-Brown B, Venkataramani AS, Nattrass N, Seekings J, Whiteside AW. A cut above the rest: traditional male circumcision and HIV risk among Xhosa men in Cape Town, South Africa. J Acquir Immune Defic Syndr. 2011 Dec 15;58(5):499–505.

    Article  PubMed  Google Scholar 

  53. Bailey RC, Egesah O, Rosenberg S. Male circumcision for HIV prevention: a prospective study of complications in clinical and traditional settings in Bungoma, Kenya. Bull World Health Organ. 2008 Sep;86(9):669–77.

    Article  PubMed  Google Scholar 

  54. Wilcken A, Keil T, Dick B. Traditional male circumcision in eastern and southern Africa: a systematic review of prevalence and complications. Bull World Health Organ. 2010 Dec 1;88(12):907–14.

    Article  PubMed  Google Scholar 

  55. World Health Organization & United Nations Joint Programme on HIV/AIDS. Male circumcision: global trends and determinants of prevalence, safety and acceptability. Geneva: WHO; 2007.

    Google Scholar 

  56. Riess TH, Achieng MM, Otieno S, Bailey RC. Risk compensation associated with the scale up of medical male circumcision among women in Kisumu, Kenya. 2012.

    Google Scholar 

  57. Lanham M, L’Engle KL, Loolpapit M, Oguma IO. Women’s roles in voluntary medical male circumcision in Nyanza Province, Kenya. PLoS One. 2012;7(9):e44825.

    Google Scholar 

  58. Wawer MJ, Makumbi F, Kigozi G, Serwadda D, Watya S, Nalugoda F, et al. Circumcision in HIV-infected men and its effect on HIV transmission to female partners in Rakai, Uganda: a randomised controlled trial. Lancet. 2009 Jul 18;374(9685):229–37.

    Article  PubMed  Google Scholar 

  59. IRIN. South Africa: male circumcision: why the delay? Humanitarian News and Analysis. 2009. http://www.irinnewsorg/Report/87315/SOUTH-AFRICA-Male-circumcision-why-the-delay Accessed March 15, 2013.

  60. Ondoa C. Africa: renew commitment to male circumcision. allAfrica. 2012. http://allafricacom/stories/201208080073html Accessed March 15, 2013.

  61. Weir SS, Pailman C, Mahlalela X, Coetzee N, Meidany F, Boerma JT. From people to places: focusing AIDS prevention efforts where it matters most. AIDS. 2003 Apr 11;17(6):895–903.

    Article  PubMed  Google Scholar 

  62. Miller KW, Wilder LB, Stillman FA, Becker DM. The feasibility of a street-intercept survey method in an African-American community. Am J Public Health. 1997 Apr;87(4):655–8.

    Article  PubMed  CAS  Google Scholar 

  63. Schackman BR, Freedberg KA, Weinstein MC, Sax PE, Losina E, Zhang H, et al. Cost-effectiveness implications of the timing of antiretroviral therapy in HIV-infected adults. Arch Intern Med. 2002 Nov 25;162(21):2478–86.

    Article  PubMed  CAS  Google Scholar 

  64. Siegfried N, Uthman OA, Rutherford GW. Optimal time for initiation of antiretroviral therapy in asymptomatic, HIV-infected, treatment-naive adults. Cochrane Database Syst Rev. 2010(3):CD008272.

    Google Scholar 

  65. When To Start Consortium, Sterne JA, May M, Costagliola D, de Wolf F, Phillips AN, et al. Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies. Lancet. 2009 Apr 18;373(9672):1352–63.

    Article  PubMed  Google Scholar 

  66. Kitahata MM, Gange SJ, Abraham AG, Merriman B, Saag MS, Justice AC, et al. Effect of early versus deferred antiretroviral therapy for HIV on survival. New Eng J Med. 2009 Apr 30;360(18):1815–26.

    Article  PubMed  CAS  Google Scholar 

  67. Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, et al. Prevention of HIV-1 infection with early antiretroviral therapy. New Eng J Med. 2011 Aug 11;365(6):493–505.

    Article  PubMed  CAS  Google Scholar 

  68. Thigpen MC, Kebaabetswe PM, Paxton LA, Smith DK, Rose CE, Segolodi TM, et al. Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana. New Eng J Med. 2012 Aug 2;367(5):423–34.

    Article  PubMed  CAS  Google Scholar 

  69. Van Damme L, Corneli A, Ahmed K, Agot K, Lombaard J, Kapiga S, et al. Preexposure prophylaxis for HIV infection among African women. New Eng J Med. 2012 Aug 2;367(5):411–22.

    Article  PubMed  CAS  Google Scholar 

  70. Grant RM, Lama JR, Anderson PL, McMahan V, Liu AY, Vargas L, et al. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. New Eng J Med. 2010 Dec 30;363(27):2587–99.

    Article  PubMed  CAS  Google Scholar 

  71. Hart GJ, Williamson LM. Increase in HIV sexual risk behaviour in homosexual men in Scotland, 1996–2002: prevention failure? Sexually Transm Infect. 2005 Oct;81(5):367–72.

    Article  CAS  Google Scholar 

  72. Kalichman SC. Post-exposure prophylaxis for HIV infection in gay and bisexual men. Implications for the future of HIV prevention. Am J Prev Med. 1998 Aug;15(2):120–7.

    Article  PubMed  CAS  Google Scholar 

  73. Dukers NH, Goudsmit J, de Wit JB, Prins M, Weverling GJ, Coutinho RA. Sexual risk behaviour relates to the virological and immunological improvements during highly active antiretroviral therapy in HIV-1 infection. AIDS. 2001 Feb 16;15(3):369–78.

    Article  PubMed  CAS  Google Scholar 

  74. Stolte IG, de Wit JB, van Eeden A, Coutinho RA, Dukers NH. Perceived viral load, but not actual HIV-1-RNA load, is associated with sexual risk behaviour among HIV-infected homosexual men. AIDS. 2004 Sep 24;18(14):1943–9.

    Article  PubMed  Google Scholar 

  75. Ostrow DE, Fox KJ, Chmiel JS, Silvestre A, Visscher BR, Vanable PA, et al. Attitudes towards highly active antiretroviral therapy are associated with sexual risk taking among HIV-infected and uninfected homosexual men. AIDS. 2002 Mar 29;16(5):775–80.

    Article  PubMed  Google Scholar 

  76. Guest G, Shattuck D, Johnson L, Akumatey B, Clarke EE, Chen PL, et al. Changes in sexual risk behavior among participants in a PrEP HIV prevention trial. Sex Transm Dis. 2008 Dec;35(12):1002–8.

    PubMed  Google Scholar 

  77. Baeten JM, Donnell D, Ndase P, Mugo NR, Campbell JD, Wangisi J, et al. Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. New Eng J Med. 2012 Aug 2;367(5):399–410.

    Article  PubMed  CAS  Google Scholar 

  78. Liu A, Vittinghoff E, Chillag K, Mayer KH, Grohskopf L, Thompson M, et al. No evidence of sexual risk compensation among HIV-uninfected men who have sex with men (MSM) participating in a tenofovir Pre-Exposure Prophylaxis (PrEP) trial. IAS Conference on HIV Pathogenesis and Treatment: Abstract no MOPE381. 2011.

    Google Scholar 

  79. Cohen CR, Montandon M, Carrico AW, Shiboski S, Bostrom A, Obure A, et al. Association of attitudes and beliefs towards antiretroviral therapy with HIV-seroprevalence in the general population of Kisumu, Kenya. PLoS One. 2009;4(3):e4573.

    Article  PubMed  Google Scholar 

  80. Ncube NM, Akunna J, Babatunde F, Nyarko A, Yatich NJ, Ellis W, et al. Sexual risk behaviour among HIV-positive persons in Kumasi, Ghana. Ghana Med J. 2012 Mar;46(1):27–33.

    PubMed  CAS  Google Scholar 

  81. Bechange S, Bunnell R, Awor A, Moore D, King R, Mermin J, et al. Two-year follow-up of sexual behavior among HIV-uninfected household members of adults taking antiretroviral therapy in Uganda: no evidence of disinhibition. AIDS Behav. 2010 Aug;14(4):816–23.

    Article  PubMed  Google Scholar 

  82. Venkatesh KK, de Bruyn G, Lurie MN, Mohapi L, Pronyk P, Moshabela M, et al. Decreased sexual risk behavior in the era of HAART among HIV-infected urban and rural South Africans attending primary care clinics. AIDS. 2010 Nov 13;24(17):2687–96.

    Article  PubMed  Google Scholar 

  83. Golub SA, Kowalczyk W, Weinberger CL, Parsons JT. Preexposure prophylaxis and predicted condom use among high-risk men who have sex with men. J Acquir Immune Defic Syndr. 2010 Aug;54(5):548–55.

    Article  PubMed  Google Scholar 

  84. Marshall BD, Wood E. Putting risk compensation to rest: reframing the relationship between risk behavior and antiretroviral therapy among injection drug users. AIDS. 2012 Nov 28;26(18):2405–7.

    Article  PubMed  Google Scholar 

  85. Rusch ML, Farzadegan H, Tarwater PM, Safaeian M, Vlahov D, Strathdee SA. Sexual risk behavior among injection drug users before widespread availability of highly active antiretroviral therapy. AIDS Behav. 2005 Sep;9(3):289–99.

    Article  PubMed  Google Scholar 

  86. Tun W, Celentano DD, Vlahov D, Strathdee SA. Attitudes toward HIV treatments influence unsafe sexual and injection practices among injecting drug users. AIDS. 2003 Sep 5;17(13):1953–62.

    Article  PubMed  Google Scholar 

  87. Tun W, Gange SJ, Vlahov D, Strathdee SA, Celentano DD. Increase in sexual risk behavior associated with immunologic response to highly active antiretroviral therapy among HIV-infected injection drug users. Clin Infect Dis. 2004 Apr 15;38(8):1167–74.

    Article  PubMed  Google Scholar 

  88. Fu TC, Westergaard RP, Lau B, Celentano DD, Vlahov D, Mehta SH, et al. Changes in sexual and drug-related risk behavior following antiretroviral therapy initiation among HIV-infected injection drug users. AIDS. 2012 Nov 28;26(18):2383–91.

    Article  PubMed  CAS  Google Scholar 

  89. Bouhnik AD, Moatti JP, Vlahov D, Gallais H, Dellamonica P, Obadia Y. Highly active antiretroviral treatment does not increase sexual risk behaviour among French HIV infected injecting drug users. J Epidemiol Community Health. 2002 May;56(5):349–53.

    Article  PubMed  Google Scholar 

  90. Vlahov D, Safaien M, Lai S, Strathdee SA, Johnson L, Sterling T, et al. Sexual and drug risk-related behaviours after initiating highly active antiretroviral therapy among injection drug users. AIDS. 2001 Nov 23;15(17):2311–6.

    Article  PubMed  CAS  Google Scholar 

  91. Kuyper L, Milloy MJ, Marshall BD, Zhang R, Kerr T, Montaner JS, et al. Does initiation of HIV antiretroviral therapy influence patterns of syringe lending among injection drug users? Addict Behav. 2011 May;36(5):560–3.

    Article  PubMed  Google Scholar 

  92. WHO. World Health Organization, HIV/AIDS, Microbicides. 2012. http://www.who.int/hiv/topics/microbicides/microbicides/en/ Accessed March 15, 2013.

  93. Venables E, Stadler J. ‘The study has taught me to be supportive of her’: empowering women and involving men in microbicide research. Cult Health Sex. (Multicenter Study Randomized Controlled Trial Research Support, Non-U.S. Gov’t). 2012;14(2):181–94.

    Article  PubMed  Google Scholar 

  94. Raphael MC. Microbicides are promoted as offering a ‘female-controlled’ HIV prevention method: so can they revolutionize the HIV crisis of young women in Kenya? J Public Health (Oxf). 2012 Dec 10;34(4):625–30.

    Article  Google Scholar 

  95. McGowan I. Rectal microbicide development. Curr Opin HIV AIDS. 2012 Nov;7(6):526–33.

    Article  PubMed  Google Scholar 

  96. Rader M, Marks G, Mansergh G, Crepaz N, Miller LC, Appleby PR, et al. Preferences about the characteristics of future HIV prevention products among men who have sex with men. AIDS Educ Prev. 2001 Apr;13(2):149–59.

    Article  PubMed  CAS  Google Scholar 

  97. Carballo-Dieguez A, O’Sullivan LF, Lin P, Dolezal C, Pollack L, Catania J. Awareness and attitudes regarding microbicides and Nonoxynol-9 use in a probability sample of gay men. AIDS Behav. (Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t). 2007 Mar;11(2):271–6.

    Article  PubMed  Google Scholar 

  98. Hogben M, Liddon N. Disinhibition and risk compensation: scope, definitions, and perspective. Sex Transm Dis. (Comment Editorial). 2008 Dec;35(12):1009–10.

    PubMed  Google Scholar 

  99. Crosby RA, Ricks J, Young A. Condom migration resulting from circumcision, microbicides and vaccines: brief review and methodological considerations. Sex Health. (Review). 2012 Mar;9(1):96–102.

    Article  PubMed  Google Scholar 

  100. Karim QA, Karim SSA, Frohlich JA, Grobler AC, Baxter C, Mansoor LE, et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science. 2010 Sep 3;329(5996):1168–74.

    Article  Google Scholar 

  101. Nyamathi AM, Suhadev M, Swaminathan S, Fahey JL. Perceptions of a community sample about participation in future HIV vaccine trials in south India. AIDS Behav. 2007 Jul;11(4):619–27.

    Article  PubMed  Google Scholar 

  102. Crosby RA, Holtgrave DR. Will sexual risk behaviour increase after being vaccinated for AIDS? Int J STD AIDS. 2006 Mar;17(3):180–4.

    Article  PubMed  Google Scholar 

  103. Chesney MA, Chambers DB, Kahn JO. Risk behavior for HIV infection in participants in preventive HIV vaccine trials: a cautionary note. J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Dec 1;16(4):266–71.

    Article  PubMed  CAS  Google Scholar 

  104. Newman PA, Lee SJ, Duan N, Rudy E, Nakazono TK, Boscardin J, et al. Preventive HIV vaccine acceptability and behavioral risk compensation among a random sample of high-risk adults in Los Angeles (LA VOICES). Health Serv Res. 2009 Dec;44(6):2167–79.

    Article  PubMed  Google Scholar 

  105. Newman PA, Roungprakhon S, Tepjan S, Yim S. Preventive HIV vaccine acceptability and behavioral risk compensation among high-risk men who have sex with men and transgenders in Thailand. Vaccine. 2010 Jan 22;28(4):958–64.

    Article  PubMed  CAS  Google Scholar 

  106. Sayles JN, Macphail CL, Newman PA, Cunningham WE. Future HIV vaccine acceptability among young adults in South Africa. Health Educ Behav. 2010 Apr;37(2):193–210.

    Article  PubMed  Google Scholar 

  107. Ayiga N, Letamo G. Impact of male circumcision on HIV risk compensation through the impediment of condom use in Botswana. Afr Health Sci. 2011 Dec;11(4):550–9.

    PubMed  CAS  Google Scholar 

  108. Marshall BD, Milloy MJ, Kerr T, Zhang R, Montaner JS, Wood E. No evidence of increased sexual risk behaviour after initiating antiretroviral therapy among people who inject drugs. AIDS. 2010 Sep 10;24(14):2271–8.

    Article  PubMed  Google Scholar 

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Correspondence to Lisa A. Eaton .

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Eaton, L., Westercamp, N., Abraham, A. (2014). Risk Compensation in Response to HIV Prevention. In: Eaton, L., Kalichman, S. (eds) Biomedical Advances in HIV Prevention. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8845-3_6

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