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Angiogenesis and Functional Recovery After Traumatic Brain Injury

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Vascular Mechanisms in CNS Trauma

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR,volume 5))

Abstract

Brain injuries caused by trauma remain a major cause of death and serious long-term disability worldwide, especially in children and young adults. However, nearly all Phase III traumatic brain injury (TBI) clinical trials have failed to provide safe and effective treatment for improving functional recovery after TBI. This review discusses recent promising preclinical and clinical data indicating that TBI promotes angiogenesis (formation of new blood vessels from preexisting endothelial cells), which couples with neurogenesis (generation of new neurons) and oligodendrogenesis (generation of new oligodendrocytes), in concert, contributing to spontaneous functional recovery. Selected cell-based and pharmacological therapies that can amplify these endogenous neurorestorative effects to enhance cognitive and neurological functional recovery after TBI are discussed. Perspectives for further investigation of angiogenesis after TBI and associated therapeutic treatments are provided.

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Acknowledgments

This work was supported by National Institutes of Health grants RO1 NS062002 (Y.X.), RO1AG037506 (M.C.).

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Authors and Affiliations

  1. Department of Neurology, Henry Ford Hospital, Education and Research Building, Room 3056, 2799 West Grand Boulevard, Detroit, MI, 48202, USA

    Michael Chopp

  2. Department of Physics, Henry Ford Hospital, Detroit, MI, USA

    Michael Chopp

  3. Oakland University, Rochester, MI, USA

    Michael Chopp

  4. Department of Neurosurgery, Henry Ford Hospital, Detroit, MI, USA

    Yanlu Zhang, Ye Xiong & Asim Mahmood

  5. Department of Neurology, Henry Ford Hospital, Detroit, MI, USA

    Zheng Gang Zhang

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  1. Yanlu Zhang
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  5. Michael Chopp
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Correspondence to Michael Chopp .

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Editors and Affiliations

  1. Departments of Neurology and Radiology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Eng H. Lo

  2. Department of Pediatrics, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Josephine Lok

  3. Department of Neurology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    MingMing Ning

  4. Department of Pediatrics, Massachusetts General Hospital Harbard Medical School, Boston, Massachusetts, USA

    Michael J. Whalen

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Zhang, Y., Xiong, Y., Mahmood, A., Zhang, Z.G., Chopp, M. (2014). Angiogenesis and Functional Recovery After Traumatic Brain Injury. In: Lo, E., Lok, J., Ning, M., Whalen, M. (eds) Vascular Mechanisms in CNS Trauma. Springer Series in Translational Stroke Research, vol 5. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8690-9_8

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  • DOI: https://doi.org/10.1007/978-1-4614-8690-9_8

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  • Online ISBN: 978-1-4614-8690-9

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