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Blood Genomics After Brain Ischemia, Hemorrhage, and Trauma

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Vascular Mechanisms in CNS Trauma

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR,volume 5))

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Abstract

Peripheral blood is routinely used for RNA expression studies. However, blood is a challenging tissue for studying gene expression due to the fact that blood has a variety of components, composed of plasma and multiple cell subsets (i.e., leukocytes, platelets, red blood cells). Most genome-wide expression studies of blood are based on analysis of leukocytes, because the leukocytes are able to recruit and migrate into the site of injury within the brain. Recently, circulating cell-free plasma RNAs have received more and more attentions for clinical applications, since increasing evidence supports that the release of RNA into plasma may be mediated by microvesicles and exosomes coming from cells undergoing necrosis and apoptosis, though the definite origin and release mechanisms of plasma RNA remain incompletely understood. Blood genomic studies will provide diagnostic, prognostic, and therapeutic markers and will advance our understanding of brain ischemia, hemorrhage, and trauma in humans. New techniques to measure all coding and noncoding RNAs along with alternatively spliced transcripts will markedly advance molecular studies of these acute brain injuries.

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Author information

Authors and Affiliations

  1. Department of Neurology and the MIND Institute, University of California at Davis, 2805 50th Street, Sacramento, CA, 95817, USA

    Da Zhi Liu

  2. Department of Neurology and the MIND Institute, University of California at Davis, Sacramento, CA, USA

    Glen C. Jickling, Boryana Stamova, Xinhua Zhan, Bradley P. Ander & Frank R. Sharp

Authors
  1. Da Zhi Liu
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  2. Glen C. Jickling
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  3. Boryana Stamova
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  4. Xinhua Zhan
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  5. Bradley P. Ander
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  6. Frank R. Sharp
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Corresponding author

Correspondence to Da Zhi Liu .

Editor information

Editors and Affiliations

  1. Departments of Neurology and Radiology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Eng H. Lo

  2. Department of Pediatrics, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Josephine Lok

  3. Department of Neurology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    MingMing Ning

  4. Department of Pediatrics, Massachusetts General Hospital Harbard Medical School, Boston, Massachusetts, USA

    Michael J. Whalen

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Liu, D.Z., Jickling, G.C., Stamova, B., Zhan, X., Ander, B.P., Sharp, F.R. (2014). Blood Genomics After Brain Ischemia, Hemorrhage, and Trauma. In: Lo, E., Lok, J., Ning, M., Whalen, M. (eds) Vascular Mechanisms in CNS Trauma. Springer Series in Translational Stroke Research, vol 5. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8690-9_26

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  • DOI: https://doi.org/10.1007/978-1-4614-8690-9_26

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-8689-3

  • Online ISBN: 978-1-4614-8690-9

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