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Cerebrovascular Responses After Pediatric Traumatic Brain Injury

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Book cover Vascular Mechanisms in CNS Trauma

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR,volume 5))

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Abstract

In children, traumatic brain injury (TBI) is the leading cause of death between the ages of one and four. Injury to the brain as a result of TBI results from primary, secondary, and tertiary insults. Neurotrauma care focuses on minimizing secondary insults, with a major focus being the maintenance of adequate cerebral blood flow (CBF). TBI can disrupt the normal flow leading to increased and decreased amounts of CBF throughout the brain. In children, these changes are dependent on the age and stage of development. This chapter discusses the effect of developmental changes on CBF, cerebral perfusion pressure, and autoregulation of CBF in children of different age groups to further investigate an effective means of limiting the secondary effects of TBI.

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Acknowledgements

Drs. Shein and Ferguson are supported by T32 HD040686. Dr. Bell is supported by U01 HD049981, R01 NS069247, and R01 NS072308. The authors report no conflicts of interest.

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Authors and Affiliations

  1. Departments of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Michael J. Bell

  2. Departments of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Michael J. Bell

  3. Departments of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Michael J. Bell

  4. Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Michael J. Bell

  5. Department of Critical Care Medicine and the Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Steven L. Shein & Nikki Miller Ferguson

Authors
  1. Steven L. Shein
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  2. Nikki Miller Ferguson
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  3. Michael J. Bell
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Corresponding author

Correspondence to Michael J. Bell .

Editor information

Editors and Affiliations

  1. Departments of Neurology and Radiology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Eng H. Lo

  2. Department of Pediatrics, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Josephine Lok

  3. Department of Neurology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    MingMing Ning

  4. Department of Pediatrics, Massachusetts General Hospital Harbard Medical School, Boston, Massachusetts, USA

    Michael J. Whalen

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Shein, S.L., Ferguson, N.M., Bell, M.J. (2014). Cerebrovascular Responses After Pediatric Traumatic Brain Injury. In: Lo, E., Lok, J., Ning, M., Whalen, M. (eds) Vascular Mechanisms in CNS Trauma. Springer Series in Translational Stroke Research, vol 5. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8690-9_24

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  • DOI: https://doi.org/10.1007/978-1-4614-8690-9_24

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-8689-3

  • Online ISBN: 978-1-4614-8690-9

  • eBook Packages: MedicineMedicine (R0)

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