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Managing Edema and Intracranial Pressure in the Intensive Care Unit

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Book cover Vascular Mechanisms in CNS Trauma

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR,volume 5))

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Abstract

Despite several decades of intensive research efforts in the laboratory and the clinic, treatment for traumatic brain injury remains supportive and directed towards controlling intracranial pressure (ICP). First-line therapies for ICP control include positioning to promote jugular venous drainage, sedation and muscle relaxation, modest hyperventilation, and hyperosmolar therapy. Second-line therapies include barbiturate coma, systemic hypothermia, and decompressive craniectomy. Although all of these therapies can be used to treat intracranial hypertension, none have been shown to improve outcome in patients with TBI. This chapter reviews the current therapies used for ICP control with an emphasis on children with TBI.

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Authors and Affiliations

  1. Department of Pediatric Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02115, USA

    Michael J. Whalen

  2. Department of Pediatrics, Division of Pediatric Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

    Brian M. Cummings, Sarah A. Murphy, Chetan Bhupali, Rebecca Bell, Zenab Mansoor & Natan Noviski

  3. Department of Pediatric Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

    Phoebe H. Yager

  4. Harvard Medical School, Boston, MA, USA

    Brian Kalish

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Correspondence to Michael J. Whalen .

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  1. Departments of Neurology and Radiology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Eng H. Lo

  2. Department of Pediatrics, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Josephine Lok

  3. Department of Neurology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    MingMing Ning

  4. Department of Pediatrics, Massachusetts General Hospital Harbard Medical School, Boston, Massachusetts, USA

    Michael J. Whalen

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Cummings, B.M. et al. (2014). Managing Edema and Intracranial Pressure in the Intensive Care Unit. In: Lo, E., Lok, J., Ning, M., Whalen, M. (eds) Vascular Mechanisms in CNS Trauma. Springer Series in Translational Stroke Research, vol 5. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8690-9_20

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