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Vascular Mechanisms in CNS Trauma pp 29–45Cite as

Mechanisms of Cerebral Edema Leading to Early Seizures After Traumatic Brain Injury

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Part of the book series: Springer Series in Translational Stroke Research ((SSTSR,volume 5))

Abstract

Epidemiological data support a link between traumatic brain injury (TBI) and seizures. TBI accounts for approximately 16 % of acute symptomatic seizures which usually occur in the first week after trauma. Children are at higher risk for posttraumatic seizures than adults and experience greater morbidity and mortality from cerebral edema (CE). CE is responsible for half of the mortality associated with TBI. A recent book chapter summarizes the most important features of posttraumatic seizure. In this chapter we will summarize features relevant to the link between cerebral edema, cerebrovascular events and seizures after TBI. In addition, we will discuss the potential autoimmune implications of TBI.

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Acknowledgements

Supported by NIH R01NS43284, R41MH093302, R21NS077236, R42MH093302, and R21HD057256 awarded to DJ.

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Authors and Affiliations

  1. Cerebrovascular Research, Departments of Neurosurgery and Cellular and Molecular Medicine, Department of Molecular Medicine, Cleveland Clinic Foundation, NB-20 LRI, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    Damir Janigro

  2. Departments of Neurosurgery and Cellular and Molecular Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA

    Philip H. Iffland II

  3. School of Biomedical Sciences, Kent State University, Kent, OH, USA

    Philip H. Iffland II

  4. Division of Neurosurgery, Department of Surgery, Duke University School of Medicine, Durham, NC, USA

    Gerald A. Grant

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  1. Philip H. Iffland II
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  2. Gerald A. Grant
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  3. Damir Janigro
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Correspondence to Damir Janigro .

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Editors and Affiliations

  1. Departments of Neurology and Radiology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Eng H. Lo

  2. Department of Pediatrics, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Josephine Lok

  3. Department of Neurology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    MingMing Ning

  4. Department of Pediatrics, Massachusetts General Hospital Harbard Medical School, Boston, Massachusetts, USA

    Michael J. Whalen

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Iffland, P.H., Grant, G.A., Janigro, D. (2014). Mechanisms of Cerebral Edema Leading to Early Seizures After Traumatic Brain Injury. In: Lo, E., Lok, J., Ning, M., Whalen, M. (eds) Vascular Mechanisms in CNS Trauma. Springer Series in Translational Stroke Research, vol 5. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8690-9_2

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