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Vascular Mechanisms in CNS Trauma pp 353–359Cite as

Isolated Blood Vessel Models for Studying Trauma

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Part of the book series: Springer Series in Translational Stroke Research ((SSTSR,volume 5))

Abstract

Abnormalities of cerebrovascular circulation are one of the salient consequences of traumatic brain injury. Severity of cerebral blood flow disregulation is associated with the negative clinical outcome. Regulation of cerebral blood flow is complex and differs from regulation of blood flow in other vascular beds. Basic vascular tone formed by interaction of vascular smooth muscle cells and endothelium provides background for other regulatory mechanisms. Understanding of traumatic brain injury-induced abnormalities of basic vascular tone formation and its adjustment using isolated brain vessel model is important for unveiling the pathophysiological mechanisms of brain trauma and development of new therapeutic approaches.

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Author information

Authors and Affiliations

  1. Feisntein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA

    Eugene V. Golanov

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  1. Eugene V. Golanov
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Correspondence to Eugene V. Golanov .

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Editors and Affiliations

  1. Departments of Neurology and Radiology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Eng H. Lo

  2. Department of Pediatrics, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Josephine Lok

  3. Department of Neurology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    MingMing Ning

  4. Department of Pediatrics, Massachusetts General Hospital Harbard Medical School, Boston, Massachusetts, USA

    Michael J. Whalen

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Golanov, E.V. (2014). Isolated Blood Vessel Models for Studying Trauma. In: Lo, E., Lok, J., Ning, M., Whalen, M. (eds) Vascular Mechanisms in CNS Trauma. Springer Series in Translational Stroke Research, vol 5. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8690-9_19

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  • DOI: https://doi.org/10.1007/978-1-4614-8690-9_19

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