Stem Cells for Neurovascular Repair in CNS Trauma

  • Mibel M. Pabón
  • Travis Dailey
  • Naoki Tajiri
  • Kazutaka Shinozuka
  • Hiroto Ishikawa
  • Sandra Acosta
  • Yuji Kaneko
  • Cesar V. Borlongan
Part of the Springer Series in Translational Stroke Research book series (SSTSR, volume 5)


Stem cells exert therapeutic effects for central nervous system (CNS) trauma. Accumulating evidence reveals that stem cell-based therapies for CNS trauma can be achieved via transplantation of exogenous stem cells or stimulation of endogenous stem cells from the neurogenic niches of subventricular zone and subgranular zone, or recruited from the bone marrow through peripheral circulation. In this chapter, we review the different sources of stem cells that have been tested in animal models of CNS trauma, highlighting the research progress on stem cell-based therapeutics in stroke and their extension to traumatic brain injury (TBI). In addition, we discuss specific mechanisms of action, in particular neurovascular repair by endothelial progenitor cells, as key translational research for advancing the clinical applications of stem cells for CNS trauma.


Permeability Migration Ischemia Lactate Superoxide 


Disclosures/Conflict of Interests: CVB is supported by NIH NINDS 5U01NS055914-04 and NIH NINDS R01NS071956-01, James and Esther King Foundation for Biomedical Research Program, and receives research grant support for his projects on bone marrow stem cell therapy for stroke from SanBio Inc., Celgene Cellular Therapeutics, KMPHC and NeuralStem Inc.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Mibel M. Pabón
    • 2
  • Travis Dailey
    • 2
  • Naoki Tajiri
    • 2
  • Kazutaka Shinozuka
    • 2
  • Hiroto Ishikawa
    • 2
  • Sandra Acosta
    • 2
  • Yuji Kaneko
    • 2
  • Cesar V. Borlongan
    • 1
  1. 1.Department of Neurosurgery and Brain RepairUniversity of South Florida College of MedicineTampaUSA
  2. 2.Department of Neurosurgery and Brain RepairUniversity of South Florida College of MedicineTampaUSA

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