Abstract
This chapter presents an example of an application of a mathematical model: the goal is here to help clinicians evaluate the aggressiveness of some metastases to the lung. For this matter, an adequate spatial model is described and two algorithms (one using a reduced model approach and the other one a sensitivity technique) are shown. They allow us to find reasonable values of the parameters of this model for a given patient with a sequence of medical images. The quality of the prognosis obtained through the calibrated model is then illustrated with several clinical cases.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Alarcón T, Byrne H, Maini P (2003) A cellular automaton model for tumour growth in inhomogeneous environment. J Theor Biol 225(2):257–274
Ambrosi D, Preziosi L (2002) On the closure of mass balance models for tumor growth. Math Models Meth Appl Sci 12(05):737–754
Anderson ARA, Weaver AM, Cummings PT, Quaranta V (2006) Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment. Cell 127(5): 905–915
Bergmann M, Bruneau CH, Iollo A (2009) Enablers for robust pod models. J Comput Phys 228:516–538
Billy F, Ribba B, Saut O, Morre-Trouilhet H, Colin T, Bresch D, Boissel J-P, Grenier E, Flandrois J (2009) A pharmacologically based multiscale mathematical model of angiogenesis and its use in investigating the efficacy of a new cancer treatment strategy. J Theor Biol 260(4):545–562. doi:10.1016/j.jtbi.2009.06.026
Bresch D, Colin T, Grenier E, Ribba B, Saut O (2009) A viscoelastic model for avascular tumor growth. Discrete Contin Dyn Syst Suppl 2009, 101–108
Byrd RH, Nocedal J, Schnabe RB (1994) Representations of quasi-Newton matrices and their use in limited memory methods. Math Program 63:129–156
Byrne H, Drasdo D (2009) Individual-based and continuum models of growing cell populations: a comparison. J Math Biol 58(4–5):657–687
Byrne HM (2010) Dissecting cancer through mathematics: from the cell to the animal model. Nat Rev Cancer 10(3):221–230
Clatz O, Sermesant M, Bondiau P-Y, Delingette H, Warfield SK, Malandain G, Ayache N (2005) Realistic simulation of the 3-d growth of brain tumors in mr images coupling diffusion with biomechanical deformation. IEEE Trans Med Imaging 24(10):1334–1346
Friedman A (2004) A hierarchy of cancer models and their mathematical challenges. Discrete Contin Math Syst Ser B 4(1):147–160
Gatenby R, Gawlinski ET (1996) A reaction-diffusion model of cancer invasion. Cancer Res 56(24):5745–5753
Hahnfeldt P, Panigrahy D, Folkman J, Hlatky L (1999) Tumor development under angiogenic signaling. Cancer Res 59(19):4770
Hanahan D, Weinberg R (2000) The hallmarks of cancer. Cell 100(1):57–70
Hanke M (1997) A regularizing Levenberg-Marquardt scheme with applications to inverse groundwater filtration problems. Inverse Probl 13:79–95
Hogea C, Davatzikos C, Biros G (2008) An image-driven parameter estimation problem for a reaction–diffusion glioma growth model with mass effects. J Math Biol 56(6):793–825
Holmes P, Lumley JL, Berkooz G (1996) Turbulence, coherent structures, dynamical systems and symmetry. Cambridge monographs on mechanics. Cambridge University Press, Cambridge
Macklin P, Lowengrub JS (2005) Evolving interfaces via gradients of geometry-dependent interior poisson problems: application to tumor growth. J Comput Phys 203(1):191–220
Mansury Y, Kimura M, Lobo J, Deisboeck T (2002) Emerging patterns in tumor systems: simulating the dynamics of multicellular clusters with an agent-based spatial agglomeration model. J Theor Biol 219(3):343–370
Mantzaris N, Webb S, Othmer H (2004) Mathematical modeling of tumor-induced angiogenesis. J Math Biol 49(2):111–187
Marzouk YM, Najm HN (2009) Dimensionality reduction and polynomial chaos acceleration of Bayesian inference in inverse problems. J Comput Phys 228(6):1862–1902
Othmer HG, Stevens A (1997) Aggregation, blowup, and collapse: the ABC’s of taxis in reinforced random walks. SIAM J Appl Math 57(4):1044–1081
Reinboldt W (1993) On the sensitivity of solutions of parametrized equations. SIAM J Numer Anal 30:305–320
Ribba B, Saut O, Colin T, Bresch D, Grenier E, Boissel J-P (2006) A multiscale mathematical model of avascular tumor growth to investigate the therapeutic benefit of anti-invasive agents. J Theor Biol 243(4):532–541
Robbins RJ, Wan Q, Grewal RK, Reibke R, Gonen M, Strauss HW, Tuttle RM, Drucker W, Larson SM (2006) Real-time prognosis for metastatic thyroid carcinoma based on 2-[18F]fluoro-2-deoxy-D-glucose-positron emission tomography scanning. J Clin Endocrinol Metab 91(2):498–505
Roose T, Chapman SJ, Maini PK (2007) Mathematical models of avascular tumor growth. SIAM Rev 49(2):179–208
Sachs LR, Hahnfeldt P (2001) Simple ODE models of tumor growth and anti-angiogenic or radiation treatment. Math Comput Model 33(12–13):1297–1305
Schlumberger M, Sherman SI (2009) Clinical trials for progressive differentiated thyroid cancer: patient selection, study design, and recent advances. Thyroid 19(12):1393–1400
Sherratt J, Chaplain M (2001) A new mathematical model for avascular tumour growth. J Math Biol 43(4):291–312
Shiraishi F, Tomita T, Iwata M, Berrada AA, Hirayama H (2009) A reliable taylor series-based computational method for the calculation of dynamic sensitivities in large-scale metabolic reaction systems: algorithm and software evaluation. Math Biosci 222:73–85
Simeoni M, Magni P, Cammia C, De Nicolao G, Croci V, Pesenti E, Germani M, Poggesi I, Rocchetti M (2004) Predictive pharmacokinetic-pharmacodynamic modeling of tumor growth kinetics in xenograft models after administration of anticancer agents. Cancer Res 64(3): 1094–1101
Sirovich L (1989) Low dimensional description of complicated phenomena. Contemp Math 99:277–305
Swanson KR, Alvord EC, Murray JD (2002) Quantifying efficacy of chemotherapy of brain tumors with homogeneous and heterogeneous drug delivery. Acta Biotheor 50(4):223–237
Tenoroio L (2001) Statistical regularization of inverse problems. SIAM Rev 43:347–366
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer New York
About this chapter
Cite this chapter
Colin, T., Iollo, A., Lombardi, D., Saut, O., Bonichon, F., Palussière, J. (2014). Some Models for the Prediction of Tumor Growth: General Framework and Applications to Metastases in the Lung. In: Garbey, M., Bass, B., Berceli, S., Collet, C., Cerveri, P. (eds) Computational Surgery and Dual Training. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8648-0_19
Download citation
DOI: https://doi.org/10.1007/978-1-4614-8648-0_19
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-8647-3
Online ISBN: 978-1-4614-8648-0
eBook Packages: EngineeringEngineering (R0)