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Genetic Pleiotropies of Obesity

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The Genetics of Obesity

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Abstract

Advances in the knowledge of variation in the human genome and reproducible results from the Genome-wide Association Studies (GWAS) have led to the identification of susceptible loci contributing to obesity and related disorders. Obesity is associated with and may contribute to the development of many metabolic diseases including, but not limited to, diabetes, hypertension, dyslipidemia, liver disease, and cardiovascular disease, often leading to morbidity and mortality; however the mechanisms linking the genetic polymorphisms associated with obesity to these metabolic complications are extremely complex and remains to be fully elucidated. In this chapter, we review a number of genetic perturbations that predispose to obesity as well as obesity-associated metabolic complications. Further understanding on how these variants act may help toward personalized treatment for obesity-related comorbidities based on individual needs.

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Acknowledgements

  This work was supported by National Institutes of Health grant K23DK080145-01, the Doris Duke Medical Foundation, and the University of Michigan Internal Medicine Department, Division of Gastroenterology, and Biological Sciences Scholars Program.

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Authors and Affiliations

  1. Department of Internal Medicine, Division of Gastroenterology, University of Michigan, 6520 MSRB I, SPC 5682, 1150W. Medical Center Drive, Ann Arbor, MI, 48109, USA

    Bratati Kahali Ph.D. & Elizabeth K. Speliotes M.D., Ph.D., M.P.H.

  2. Department of Computational Medicine and Bioinformatics, University of Michigan, 6520 MSRB I, SPC 5682, 1150W. Medical Center Drive, Ann Arbor, MI, 48109, USA

    Bratati Kahali Ph.D. & Elizabeth K. Speliotes M.D., Ph.D., M.P.H.

Authors
  1. Bratati Kahali Ph.D.
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  2. Elizabeth K. Speliotes M.D., Ph.D., M.P.H.
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Correspondence to Elizabeth K. Speliotes M.D., Ph.D., M.P.H. .

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  1. Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, USA

    Struan F.A. Grant

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Kahali, B., Speliotes, E.K. (2014). Genetic Pleiotropies of Obesity. In: Grant, S. (eds) The Genetics of Obesity. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8642-8_6

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