Genetic Obesity Syndromes

  • I. Sadaf Farooqi
  • Stephen O’Rahilly


A number of genetic obesity syndromes have been identified by sequencing candidate genes in patients with severe obesity. Many of the initial findings emerged from studying families who displayed a classical Mendelian pattern of inheritance; however, with more comprehensive genome wide approaches, increasingly more complex models of inheritance are likely to emerge. The functional and physiological characterization of the human obesity syndromes has provided information that has diagnostic value (Fig. 2.1), has led to specific treatments in some patients and continues to provide insights into the mechanisms involved in the regulation of body weight in humans.


Early Onset Obesity Biedl Syndrome MC4R Mutation Melanocortin Signalling WAGR Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Metabolic Diseases UnitWellcome Trust-MRC Institute of Metabolic ScienceCambridgeUK

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