Skip to main content
SpringerLink
Log in
Book cover

Ovarian Neoplasm Imaging pp 263–268Cite as

Rare Malignant Tumor (Clear Cell Adenocarcinoma, Transitional Cell Carcinoma, Malignant Brenner Tumor) (Clinical Setting and US)

  • Chapter
  • First Online:

  • 1849 Accesses

Abstract

Clear cell carcinomas and transitional cell tumors represent rare histotypes of epithelial ovarian tumors. Two clinicopathologic types of malignant transitional cell tumor have been described: malignant Brenner tumor, in which a benign or atypical proliferative (borderline) Brenner component is identified within or contiguous with the tumor, and transitional cells carcinoma (TCC), in which no benign or borderline Brenner is identified.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Alcázar JL, Guerriero S, Pascual MÁ, Ajossa S, Olartecoechea B, Hereter L. Clinical and sonographic features of uncommon primary ovarian malignancies. J Clin Ultrasound. 2012;40:323–9.

    Article  PubMed  Google Scholar 

  2. Kurman RJ. Blaustein’s pathology of the female genital tract. 6th ed. New York: Springer; 2011.

    Book  Google Scholar 

  3. Pather S, Quinn MA. Clear cell cancer of the ovary-is it chemosensitive? Int J Gynecol Cancer. 2004;15:432–7.

    Article  Google Scholar 

  4. Tan DSP, Kaye S. Ovarian clear cell adenocarcinoma: a continuing enigma. J Clin Pathol. 2007;60:355–60.

    Article  CAS  PubMed  Google Scholar 

  5. Chung HH, Hwang SY, Jung KW, Won YJ, Shin HR, Kim JW, Lee HP, Gynecologic Oncology Committee of Korean Society of Obstetrics and Gynecology. Ovarian cancer incidence and survival in Korea: 1993–2002. Int J Gynecol Cancer. 2007;17:595–600.

    Article  CAS  PubMed  Google Scholar 

  6. Mizuno M, Kikkawa F, Shibata K, Kajiyama H, Suzuki T, Ino K, Kawai M, Mizutani S. Long-term prognosis of stage I ovarian carcinoma. Prognostic importance of intraoperative rupture. Oncology. 2003;65:29–36.

    Article  PubMed  Google Scholar 

  7. Seidman JD, Yemelyanova AV, Khedmati F, Bidus MA, Dainty L, Boice CR, Cosin JA. Prognostic factors for stage I ovarian carcinoma. Int J Gynecol Pathol. 2010;29:1–7.

    Article  PubMed  Google Scholar 

  8. Chan JK, Teoh D, Hu JM, Shin JY, Osann K, Kapp DS. Do clear cell ovarian carcinomas have poorer prognosis compared to other epithelial cell types? A study of 1411 clear cell ovarian cancers. Gynecol Oncol. 2008;109:370–6.

    Article  PubMed  Google Scholar 

  9. Timmers PJ, Zwinderman AH, Teodorovic I, Vergote I, Trimbos JB. Clear cell carcinoma compared to serous carcinoma in early ovarian cancer: same prognosis in a large randomized trial. Int J Gynecol Cancer. 2009;19:88–93.

    Article  CAS  PubMed  Google Scholar 

  10. Chan JK, Tian C, Monk BJ, Herzog T, Kapp DS, Bell J, Young RC, Gynecologic Oncology Group. Prognostic factors for high-risk early-stage epithelial ovarian cancer: a Gynecologic Oncology Group study. Cancer. 2008;112:2202–10.

    Article  PubMed  Google Scholar 

  11. Van Holsbeke C, Van Belle V, Leone FP, Guerriero S, Paladini D, Melis GB, Greggi S, Fischerova D, De Jonge E, Neven P, Bourne T, Valentin L, Van Huffel S, Timmerman D. Prospective external validation of the ‘ovarian crescent sign’ as a single ultrasound parameter to distinguish between benign and malignant adnexal pathology. Ultrasound Obstet Gynecol. 2010;36:81–7.

    Article  PubMed  Google Scholar 

  12. Testa AC, Timmerman D, Van Holsbeke C, Zannoni GF, Fransis S, Moerman P, Vellone V, Mascilini F, Licameli A, Ludovisi M, Di Legge A, Scambia G, Ferrandina G. Ovarian cancer arising in endometrioid cysts: ultrasound findings. Ultrasound Obstet Gynecol. 2011;38:99–106.

    Article  CAS  PubMed  Google Scholar 

  13. Jorgensen EO, Dockerty MB, Wilson RB, Welch JS. Clinicopathologic study of 53 cases of Brenner’s tumors of the ovary. Am J Obstet Gynecol. 1970;108:122–7.

    CAS  PubMed  Google Scholar 

  14. Austin R, Norris H. Malignant Brenner tumor and transitional cell carcinoma of the ovary: a comparison. Int J Gynecol Pathol. 1987;6:29–39.

    Article  CAS  PubMed  Google Scholar 

  15. Tazi E, Lalya I, Tazi M, Ahellal Y, M’rabti H, Errihani H. Transitional cell carcinoma of the ovary: a rare case and review of literature. World J Surg Oncol. 2010;8:98–101.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  16. Lin C, Liu F, Ho E. Transitional cell carcinoma of the ovary. Taiwan J Obstet Gynecol. 2006;45:268–71.

    Article  PubMed  Google Scholar 

  17. Eichhorn J, Young R. Transitional cell carcinoma of the ovary: a morphologic study of 100 cases with emphasis on differential diagnosis. Am J Surg Pathol. 2004;28:453–63.

    Article  PubMed  Google Scholar 

  18. Green GE, Mortele KJ, Glickman JN, Benson CB. Brenner tumors of the ovary: sonographic and computed tomographic imaging features. J Ultrasound Med. 2006;25:1245–51.

    PubMed  Google Scholar 

  19. Balasa RW, Adcock LL, Prem KA, Dehner LP. The Brenner tumor: a clinicopathologic review. Obstet Gynecol. 1977;50:120–8.

    CAS  PubMed  Google Scholar 

  20. Silverberg SG. Brenner tumor of the ovary: a clinicopathologic study of 60 tumors in 54 women. Cancer. 1971;28:588–96.

    Article  CAS  PubMed  Google Scholar 

  21. Ehrlich CE, Roth LM. The Brenner tumor. A clinicopathologic study of 57 cases. Cancer. 1971;27:332–42.

    Article  CAS  PubMed  Google Scholar 

  22. Fox H, Agrawal K, Langley FA. The Brenner tumour of the ovary: a clinicopathologic study of 54 cases. J Obstet Gynaecol Br Commonw. 1972;79:661–5.

    Article  CAS  PubMed  Google Scholar 

  23. Hermanns B, Faridi A, Rath W, Füzesi L, Schröder W. Differential diagnosis, prognostic factors, and clinical treatment of proliferative Brenner tumor of the ovary. Ultrastruct Pathol. 2000;24:191–6.

    Article  CAS  PubMed  Google Scholar 

  24. Yoonessi M, Abell MR. Brenner tumors of the ovary. Obstet Gynecol. 1979;54:90–6.

    Article  CAS  PubMed  Google Scholar 

  25. Roth LM, Czernobilsky B. Ovarian Brenner tumors. II. Malignant. Cancer. 1985;56:592–601.

    Article  CAS  PubMed  Google Scholar 

  26. Dierickx I, Valentin L, Van Holsbeke C, Jacomen G, Lissoni AA, Licameli A, Testa A, Bourne T, Timmerman D. Imaging in gynecological disease (7): clinical and ultrasound features of Brenner tumors of the ovary. Ultrasound Obstet Gynecol. 2012;40(6):706–13.

    Article  CAS  PubMed  Google Scholar 

  27. Kommoss F, Kommoss S, Schmidt D, Trunk M, Pfisterer J, du Bois A. Survival benefit for patients with advanced-stage transitional cell carcinomas vs. other subtypes of ovarian carcinoma after chemotherapy with platinum and paclitaxel. Gynecol Oncol. 2005;97:195–9.

    Article  CAS  PubMed  Google Scholar 

  28. Hata K, Hata T, Senoh D, Kitao M. Doppler ultrasound in a patient with ovarian Brenner tumor of low malignant potential: comparison with gray-scale ultrasound, magnetic resonance imaging and tumor marker suggesting malignancy. Gynecol Obstet Invest. 1997;43:135–8.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Gynecology, Catholic University of Sacred Heart, Largo A. Gemelli 8, Rome, 00168, Italy

    Testa Antonia Carla, Ludovisi Manuela, De Blasis Ilaria, Giansiracusa Carmelo & Mascilini Floriana

Authors
  1. Testa Antonia Carla
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ludovisi Manuela
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. De Blasis Ilaria
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Giansiracusa Carmelo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Mascilini Floriana
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Cagliari, Cagliari, Italy

    Luca Saba

  2. Ngee Ann Polytechnic, Singapore, Singapore

    U. Rajendra Acharya

  3. University of Cagliari, Cagliari, Italy

    Stefano Guerriero

  4. Biomedical Technologies, Inc, Roseville, California, USA

    Jasjit S. Suri

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media New York

About this chapter

Cite this chapter

Carla, T.A., Manuela, L., Ilaria, D.B., Carmelo, G., Floriana, M. (2013). Rare Malignant Tumor (Clear Cell Adenocarcinoma, Transitional Cell Carcinoma, Malignant Brenner Tumor) (Clinical Setting and US). In: Saba, L., Acharya, U., Guerriero, S., Suri, J. (eds) Ovarian Neoplasm Imaging. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-8633-6_16

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-8633-6_16

  • Published:

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4614-8632-9

  • Online ISBN: 978-1-4614-8633-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation