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Fundamentals of Chromatin pp 213–256Cite as

Histone Methylation in Chromatin Signaling

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Abstract

In this chapter we first provide a broad overview of some of the major discoveries that form the foundation of the histone methylation field. We then describe the main components involved in histone methylation signaling: the enzymes (“writers” and “erases”), the substrates, and the “readers,” and how together these components integrate to regulate critical nuclear and epigenetic programs. We also discuss how histone methylation is coordinated with DNA methylation, an important regulator of epigenetics. Finally, we describe some well-defined clinically important cases of histone methylation.

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Acknowledgments

We thank Dr. Mark Bedford for providing critical advice and members of the Gozani and Shi labs for critical reading of the work. This work was supported in part by grants from the NIH to O. Gozani (R01 GM079641, R01CA172560) and to Y. Shi (RO1CA118487, RO1MH096006). O. Gozani and Y. Shi are recipients of an Ellison Senior Scholar in Aging Award. Y. Shi is an American Cancer Society Research Professor.

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Authors and Affiliations

  1. Department of Biology, Stanford University, Stanford, CA, 94305, USA

    Or Gozani

  2. Department of Cell Biology, Harvard Medical School, Boston, MA, 02115, USA

    Yang Shi

  3. Division of Newborn Medicine, Department of Medicine, Children’s Hospital, Harvard Medical School, Boston, MA, 02115, USA

    Yang Shi

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  1. Or Gozani
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  2. Yang Shi
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Correspondence to Or Gozani or Yang Shi .

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Editors and Affiliations

  1. Stowers Institute for Medical Research, Kansas City, Missouri, USA

    Jerry L. Workman

  2. Stowers Institute for Medical Research, Kansas City, Missouri, USA

    Susan M. Abmayr

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Gozani, O., Shi, Y. (2014). Histone Methylation in Chromatin Signaling. In: Workman, J., Abmayr, S. (eds) Fundamentals of Chromatin. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8624-4_5

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