Miscellaneous access device insertion procedures and diagnostic biopsy are presented. Meticulous technique during insertion will avert pneumothorax and vascular or nerve damage. Sural nerve biopsy is a well-established diagnostic procedure for peripheral neuropathies. Muscle biopsies can be useful to help diagnose patients with and without neuropathy who present with symptoms such as weakness, muscle pain, cramps, and fatigue with activity. Temporal artery biopsy is used to diagnose patients with symptoms such as fever, weight loss, or malaise and more specifically headaches, loss of visual acuity, diplopia, and temporal artery tenderness.