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Celiac Disease pp 39–51Cite as

The Pathophysiology of Celiac Disease

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Part of the book series: Clinical Gastroenterology ((CG))

Abstract

Over the last 25 years, with the concerted effort of many researchers, we have learned a lot about the pathophysiology of celiac disease (CD). Now, CD is the best understood autoimmune/immune-mediated illness. This chapter will discuss current understanding of gluten as an antigen, antigen-presentation, and the role of HLA-DQ2/DQ8, how gluten peptides cross the intestinal epithelial cell barrier, the importance of tissue transglutaminase for modifying gluten peptides for presentation, the role of intestinal T cells in coordinating inflammation, how intraepithelial lymphocytes are triggered to attack intestinal epithelial cells, and the role of antibody response.

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Author information

Authors and Affiliations

  1. Division of Gastroenterology/Hepatology, Department of Internal Medicine, University of Iowa Carver College of Medicine and Iowa City VAHC, Iowa City, IA, USA

    David E. Elliott M.D., Ph.D.

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  1. David E. Elliott M.D., Ph.D.
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Correspondence to David E. Elliott M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Department of Medicine, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA

    S. Devi Rampertab

  2. Department of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Gerard E. Mullin

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Elliott, D.E. (2014). The Pathophysiology of Celiac Disease. In: Rampertab, S., Mullin, G. (eds) Celiac Disease. Clinical Gastroenterology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-8560-5_4

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  • DOI: https://doi.org/10.1007/978-1-4614-8560-5_4

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  • Publisher Name: Humana Press, New York, NY

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  • Online ISBN: 978-1-4614-8560-5

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