The Role of Radiation Therapy in the Treatment of Multiple Myeloma, Plasmacytoma, and Other Plasma Cell Disorders

Chapter

Abstract

Plasma cell malignancies are radioresponsive. Radiation is used as primary or adjunctive therapy of plasma cell disorders (PCDs). Palliation of symptoms is the commonest indication for radiation to the skeletal and soft tissue myelomatous lesions. Other indications include pretransplant conditioning, myeloma-related cord compression, or impending pathological fractures. Radiation is also utilized in the management of solitary osseous and extramedullary plasmacytomas, POEMS syndrome with a limited number of lesions, localized AL amyloidosis and rarely, Waldenström’s macroglobulinemia. Anecdotal reports outlining successful use of radiation with novel anti-myeloma agents exist. This chapter focuses on conventional radiation and chemo-radiation-based management strategies in PCDs.

Keywords

Fractionation Dexamethasone Melphalan Cyclophosphamide Myeloma 

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Copyright information

© Mayo Foundation for Medical Education and Research 2014

Authors and Affiliations

  1. 1.Division of Hematology, Department of Internal MedicineMayo ClinicRochesterUSA
  2. 2.Division of Radiation OncologyMayo ClinicRochesterUSA

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