Skip to main content
SpringerLink
Log in

Vertebral Augmentation

  • Chapter
  • First Online:
Book cover Multiple Myeloma

  • 2194 Accesses

Abstract

Treatment of painful vertebral compression fractures by spinal augmentation was first introduced in 1987 when Galibert et al. injected acrylic cement percutaneously into the vertebral column of patients with vertebral angiomas [1]. Since that time, it has gained acceptance around the world as a minimally invasive and effective procedure to alleviate painful spinal lesions after more conservative treatment options such as drugs and supportive care prove inadequate. Its use has been expanded, especially in the last decade, to treatment of fractures resulting from osteoporosis, metastatic cancer, and multiple myeloma.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Galibert P, Deramond H, Rosat P, Le Gars D. Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty. Neurochirurgie. 1987;33(2):166–8. Epub 1987/01/01.

    PubMed  CAS  Google Scholar 

  2. Gangi A, Guth S, Imbert JP, Marin H, Dietemann JL. Percutaneous vertebroplasty: indications, technique, and results. Radiographics. 2003;23(2):e10. Epub 2003/08/02.

    Article  PubMed  Google Scholar 

  3. Kasperk C, Hillmeier J, Noldge G, Grafe IA, Dafonseca K, Raupp D, et al. Treatment of painful vertebral fractures by kyphoplasty in patients with primary osteoporosis: a prospective nonrandomized controlled study. J Bone Miner Res. 2005;20(4):604–12. Epub 2005/03/15.

    Article  PubMed  Google Scholar 

  4. Noldge G, DaFonseca K, Grafe I, Libicher M, Hillmeier J, Meeder PJ, et al. Balloon kyphoplasty in the treatment of back pain. Radiologe. 2006;46(6):506–12. Epub 2006/06/21.

    Article  PubMed  CAS  Google Scholar 

  5. Gill JB, Kuper M, Chin PC, Zhang Y, Schutt Jr R. Comparing pain reduction following kyphoplasty and vertebroplasty for osteoporotic vertebral compression fractures. Pain Physician. 2007;10(4):583–90. Epub 2007/07/31.

    PubMed  Google Scholar 

  6. Mathis JM, Barr JD, Belkoff SM, Barr MS, Jensen ME, Deramond H. Percutaneous vertebroplasty: a developing standard of care for vertebral compression fractures. AJNR Am J Neuroradiol. 2001;22(2):373–81. Epub 2001/02/07.

    PubMed  CAS  Google Scholar 

  7. Mundy GR, Luben RA, Raisz LG, Oppenheim JJ, Buell DN. Bone-resorbing activity in supernatants from lymphoid cell lines. N Engl J Med. 1974;290(16):867–71. Epub 1974/04/18.

    Article  PubMed  CAS  Google Scholar 

  8. Ramos L, de Las Heras JA, Sanchez S, Gonzalez-Porras JR, Gonzalez R, Mateos MV, et al. Medium-term results of percutaneous vertebroplasty in multiple myeloma. Eur J Haematol. 2006;77(1):7–13. Epub 2006/04/13.

    Article  PubMed  Google Scholar 

  9. Papanastassiou ID, Phillips FM, Van Meirhaeghe J, Berenson JR, Andersson GB, Chung G, et al. Comparing effects of kyphoplasty, vertebroplasty, and non-surgical management in a systematic review of randomized and non-randomized controlled studies. Eur Spine J. 2012;21(9):1826–43. Epub 2012/05/01.

    Article  PubMed  Google Scholar 

  10. Rhyne 3rd A, Banit D, Laxer E, Odum S, Nussman D. Kyphoplasty: report of eighty-two thoracolumbar osteoporotic vertebral fractures. J Orthop Trauma. 2004;18(5):294–9. Epub 2004/04/24.

    Article  PubMed  Google Scholar 

  11. McGirt MJ, Parker SL, Wolinsky JP, Witham TF, Bydon A, Gokaslan ZL. Vertebroplasty and kyphoplasty for the treatment of vertebral compression fractures: an evidenced-based review of the literature. Spine J. 2009;9(6):501–8. Epub 2009/03/03.

    Article  PubMed  Google Scholar 

  12. Han S, Wan S, Ning L, Tong Y, Zhang J, Fan S. Percutaneous vertebroplasty versus balloon kyphoplasty for treatment of osteoporotic vertebral compression fracture: a meta-analysis of randomised and non-randomised controlled trials. Int Orthop. 2011;35(9):1349–58. Epub 2011/06/04.

    Article  PubMed  Google Scholar 

  13. Mendoza TR, Koyyalagunta D, Burton AW, Thomas SK, Phan MH, Giralt SA, et al. Changes in pain and other symptoms in patients with painful multiple myeloma-related vertebral fracture treated with kyphoplasty or vertebroplasty. J Pain. 2012;13(6):564–70. Epub 2012/05/01.

    Article  PubMed  Google Scholar 

  14. Chen LH, Hsieh MK, Niu CC, Fu TS, Lai PL, Chen WJ. Percutaneous vertebroplasty for pathological vertebral compression fractures secondary to multiple myeloma. Arch Orthop Trauma Surg. 2012;132(6):759–64. Epub 2012/02/09.

    Article  PubMed  Google Scholar 

  15. Yang Z, Tan J, Xu Y, Sun H, Xie L, Zhao R, et al. Treatment of MM-associated spinal fracture with percutaneous vertebroplasty (PVP) and chemotherapy. Eur Spine J. 2012;21(5):912–9. Epub 2011/12/17.

    Article  PubMed  Google Scholar 

  16. Trumm C, Jakobs T, Pahl A, Stahl R, Helmberger T, Paprottka P, et al. CT fluoroscopy-guided percutaneous vertebroplasty in patients with multiple myeloma: analysis of technical results from 44 sessions with 67 vertebrae treated. Diagn Interv Radiol. 2012;18(1):111–20. Epub 2011/10/19.

    PubMed  Google Scholar 

  17. Kasperk C, Haas A, Hillengass J, Weiss C, Neben K, Goldschmidt H, et al. Kyphoplasty in patients with multiple myeloma a retrospective comparative pilot study. J Surg Oncol. 2012;105(7):679–86. Epub 2011/10/01.

    Article  PubMed  Google Scholar 

  18. Basile A, Cavalli M, Fiumara P, Di Raimondo F, Mundo E, Caltabiano G, et al. Vertebroplasty in multiple myeloma with osteolysis or fracture of the posterior vertebral wall. Usefulness of a delayed cement injection. Skeletal Radiol. 2011;40(7):913–9. Epub 2011/03/02.

    Article  PubMed  Google Scholar 

  19. Anselmetti GC, Manca A, Montemurro F, Hirsch J, Chiara G, Grignani G, et al. Percutaneous vertebroplasty in multiple myeloma: prospective long-term follow-up in 106 consecutive patients. Cardiovasc Intervent Radiol. 2012;35(1):139–45. Epub 2011/02/10.

    Article  PubMed  Google Scholar 

  20. Masala S, Volpi T, Fucci FP, Cantonetti M, Postorino M, Simonetti G. Percutaneus osteoplasty in the treatment of extraspinal painful multiple myeloma lesions. Support Care Cancer. 2011;19(7):957–62. Epub 2010/05/28.

    Article  PubMed  Google Scholar 

  21. Astolfi S, Scaramuzzo L, Logroscino CA. A minimally invasive surgical treatment possibility of osteolytic vertebral collapse in multiple myeloma. Eur Spine J. 2009;18 Suppl 1:115–21. Epub 2009/05/14.

    Article  PubMed  Google Scholar 

  22. Masala S, Anselmetti GC, Marcia S, Massari F, Manca A, Simonetti G. Percutaneous vertebroplasty in multiple myeloma vertebral involvement. J Spinal Disord Tech. 2008;21(5):344–8. Epub 2008/07/05.

    Article  PubMed  Google Scholar 

  23. McDonald RJ, Trout AT, Gray LA, Dispenzieri A, Thielen KR, Kallmes DF. Vertebroplasty in multiple myeloma: outcomes in a large patient series. AJNR Am J Neuroradiol. 2008;29(4):642–8. Epub 2008/01/19.

    Article  PubMed  CAS  Google Scholar 

  24. Tran Thang NN, Abdo G, Martin JB, Seium-Neberay Y, Yilmaz H, Verbist MC, et al. Percutaneous cementoplasty in multiple myeloma: a valuable adjunct for pain control and ambulation maintenance. Support Care Cancer. 2008;16(8):891–6. Epub 2007/10/26.

    Article  PubMed  Google Scholar 

  25. Kose KC, Cebesoy O, Akan B, Altinel L, Dincer D, Yazar T. Functional results of vertebral augmentation techniques in pathological vertebral fractures of myelomatous patients. J Natl Med Assoc. 2006;98(10):1654–8. Epub 2006/10/21.

    PubMed  Google Scholar 

  26. Khanna AJ, Reinhardt MK, Togawa D, Lieberman IH. Functional outcomes of kyphoplasty for the treatment of osteoporotic and osteolytic vertebral compression fractures. Osteoporos Int. 2006;17(6):817–26. Epub 2006/03/07.

    Article  PubMed  CAS  Google Scholar 

  27. Pflugmacher R, Kandziora F, Schroeder RJ, Melcher I, Haas NP, Klostermann CK. Percutaneous balloon kyphoplasty in the treatment of pathological vertebral body fracture and deformity in multiple myeloma: a one-year follow-up. Acta Radiol. 2006;47(4):369–76. Epub 2006/06/03.

    Article  PubMed  CAS  Google Scholar 

  28. Bosnjakovic P, Ristic S, Mrvic M, Miljkovic AE, Vukicevic T, Marjanovic G, et al. Management of painful spinal lesions caused by multiple myeloma using percutaneous acrylic cement injection. Acta Chir Iugosl. 2009;56(4):153–8. Epub 2009/01/01.

    Article  PubMed  CAS  Google Scholar 

  29. Huber FX, McArthur N, Tanner M, Gritzbach B, Schoierer O, Rothfischer W, et al. Kyphoplasty for patients with multiple myeloma is a safe surgical procedure: results from a large patient cohort. Clin Lymphoma Myeloma. 2009;9(5):375–80. Epub 2009/10/28.

    Article  PubMed  Google Scholar 

  30. Zou J, Mei X, Gan M, Yang H. Kyphoplasty for spinal fractures from multiple myeloma. J Surg Oncol. 2010;102(1):43–7. Epub 2010/06/26.

    Article  PubMed  Google Scholar 

  31. Julka A, Tolhurst SR, Srinivasan RC, Graziano GP. Functional outcomes and height restoration for patients with multiple myeloma-related osteolytic vertebral compression fractures treated with kyphoplasty. J Spinal Disord Tech. 2012. Epub 2012/06/01.

    Google Scholar 

  32. Lane JM, Hong R, Koob J, Kiechle T, Niesvizky R, Pearse R, et al. Kyphoplasty enhances function and structural alignment in multiple myeloma. Clin Orthop Relat Res. 2004;426:49–53. Epub 2004/09/04.

    Article  PubMed  Google Scholar 

  33. Garland P, Gishen P, Rahemtulla A. Percutaneous vertebroplasty to treat painful myelomatous vertebral deposits-long-term efficacy outcomes. Ann Hematol. 2011;90(1):95–100. Epub 2010/07/08.

    Article  PubMed  Google Scholar 

  34. Lim BS, Chang UK, Youn SM. Clinical outcomes after percutaneous vertebroplasty for pathologic compression fractures in osteolytic metastatic spinal disease. J Korean Neurosurg Soc. 2009;45(6):369–74. Epub 2009/07/18.

    Article  PubMed  Google Scholar 

  35. Dudeney S, Lieberman IH, Reinhardt MK, Hussein M. Kyphoplasty in the treatment of osteolytic vertebral compression fractures as a result of multiple myeloma. J Clin Oncol. 2002;20(9):2382–7. Epub 2002/05/01.

    Article  PubMed  CAS  Google Scholar 

  36. Tancioni F, Lorenzetti M, Navarria P, Nozza A, Castagna L, Gaetani P, et al. Vertebroplasty for pain relief and spinal stabilization in multiple myeloma. Neurol Sci. 2010;31(2):151–7. Epub 2010/01/16.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Radiology, Mayo Clinic, 200 First Street, Southwest, Rochester, MN, 55905, USA

    Omar Khan & David Kallmes M.D.

Authors
  1. Omar Khan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. David Kallmes M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to David Kallmes M.D. .

Editor information

Editors and Affiliations

  1. Mayo Clinic, Department of Internal Medicine Division of Hematology, Rochester, Minnesota, USA

    Morie A. Gertz

  2. Mayo Clinic, Myeloma Amyloidosis Dysproteinemia Group Division of Hematology, Rochester, Minnesota, USA

    S. Vincent Rajkumar

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Mayo Foundation for Medical Education and Research

About this chapter

Cite this chapter

Khan, O., Kallmes, D. (2014). Vertebral Augmentation. In: Gertz, M., Rajkumar, S. (eds) Multiple Myeloma. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8520-9_18

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-8520-9_18

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-8519-3

  • Online ISBN: 978-1-4614-8520-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation