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Preclinical Visualization of Hypoxia, Proliferation and Glucose Metabolism in Non-small Cell Lung Cancer and Its Metastasis

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Abdomen and Thoracic Imaging

Abstract

Lung cancer is responsible for more deaths than any other cancers; most cancer-related deaths are due to the development of metastatic diseases rather than the progression of the primary tumors. Tumor hypoxia has been commonly observed in a broad spectrum of primary solid malignancies, which is associated with tumor progression, increased aggressiveness, enhanced metastatic potential, and poor prognosis. Hypoxic cancer cells are resistant to radiotherapy and some forms of chemotherapy. In this chapter, nuclear molecular imaging microenvironment including hypoxia, proliferation, and glucose metabolism in lung cancer metastases was discussed.

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Acknowledgment

The studies presented in this article were partially supported by Kentucky Lung Cancer Research Program Award.

Author information

Authors and Affiliations

  1. Department of Diagnostic Radiology, University of Louisville School of Medicine, 530 S. Jackson Street, CCB-C07, Louisville, KY, 40202, USA

    Xiao-Feng Li M.D., Ph.D.

  2. Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA

    Yuanyuan Ma M.D., Ph.D.

Authors
  1. Xiao-Feng Li M.D., Ph.D.
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  2. Yuanyuan Ma M.D., Ph.D.
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Corresponding author

Correspondence to Xiao-Feng Li M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Department of Bioengineering, University of Louisville, Louisville, Kentucky, USA

    Ayman S. El-Baz

  2. University of Cagliari, Cagliari, Italy

    Luca Saba

  3. Biomedical Technologies, Inc Idaho State University (Affiliated), Roseville, California, USA

    Jasjit Suri

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Li, XF., Ma, Y. (2014). Preclinical Visualization of Hypoxia, Proliferation and Glucose Metabolism in Non-small Cell Lung Cancer and Its Metastasis. In: El-Baz, A., Saba, L., Suri, J. (eds) Abdomen and Thoracic Imaging. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-8498-1_20

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  • DOI: https://doi.org/10.1007/978-1-4614-8498-1_20

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  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4614-8497-4

  • Online ISBN: 978-1-4614-8498-1

  • eBook Packages: MedicineMedicine (R0)

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