Colorectal Cancer: Metastatic (Palliation)
Approximately 20 % of colorectal cancer patients present with established distant metastases. A diagnosis of stage IV disease allows for appropriate operative and oncologic planning.
Among these patients there is enormous heterogeneity with respect to sites of disease, extent of disease, symptoms, performance status, and comorbidities. The clinical spectrum at the time of diagnosis ranges from the asymptomatic patient with a single metastatic lesion to the rapidly deteriorating patient with colon obstruction and advanced, multiorgan metastases.
While treatment algorithms may exist for some forms of metastatic disease such as a solitary liver lesion, others are still being defined.