Advertisement

Hereditary Colorectal Cancer

  • James Church
Chapter

Abstract

  • Colorectal cancer is both a genetic and epigenetic disease.

  • The classes of genes primarily involved are largely those concerned with regulation of cell growth, tumor suppressor genes and proto-oncogenes, and the average sporadic colorectal cancer has accumulated 90 different mutations.

  • Most mutations occur because of the environment and about one third of colorectal cancers have a hereditary component.

  • Hereditary colorectal cancer is important because members of affected families can be identified as high risk and be advised to have early, intensive surveillance or even prophylactic surgery.

  • Hereditary colorectal cancer can be broadly divided into non-syndromic and syndromic conditions.

Keywords

Familial Adenomatous Polyposis Lynch Syndrome Serrate Polyp Juvenile Polyposis Amsterdam Criterion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of Colorectal SurgeryDigestive Diseases Institute, Cleveland Clinic FoundationClevelandUSA

Personalised recommendations