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A History of Research in Anesthesia

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The Wondrous Story of Anesthesia

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Abstract

Research in anesthesia has taken several forms. Other essays in this book supply detailed histories of those specific researches, including the discovery of new anesthetics and anesthetic adjuvant drugs, advances in anesthetic delivery and monitoring, measurement and codification of anesthetic pharmacodynamics and kinetics, and the development of vehicles for the exchange of information on research (societies, books and journals). We refer the reader to these chapters for details of the histories of specific researches. The present chapter supplies an overview, a summary of the progress in anesthesia research.

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References

  1. Adriani J. The pharmacology of anesthetic drugs. Springfield: Charles C Thomas; 1952

    Google Scholar 

  2. Weese H, Scharpff W. Evipan, cin neuartiges Einschlafmittel. Deut Med Wochenschr. 1932;58:1205–7.

    Article  Google Scholar 

  3. Bernard C. Etudes phsiologiques sue quelques poisons americains. Revue des Deux Mondes 1864;53:164–90.

    Google Scholar 

  4. Griffith HR, Johnson E. The use of curare in general anesthesia. Anesthesiology. 1942;3:418–20.

    Article  CAS  Google Scholar 

  5. Holmdahl MH. Xylocain (lidocaine, lignocaine), its discovery and Gordh’s contribution to its clinical use. Acta Anaesthesiol Scand Suppl. 1998;113:8–12

    Google Scholar 

  6. Johnstone M. Halothane: the first five years. Anesthesiology. 1961;22:591–614.

    Article  CAS  PubMed  Google Scholar 

  7. Vitcha JF. A history of Forane®. Anesthesiology. 1971;35:4–7.

    Article  CAS  PubMed  Google Scholar 

  8. Terrell RC. The invention and development of enflurane, isoflurane, sevoflurane, and desflurane. Anesthesiology. 2008;108:531–3.

    Article  CAS  PubMed  Google Scholar 

  9. Wallin RF, Regan BM, Napoli MD, Stern IJ. Sevoflurane: A new inhalational anesthetic agent. Anesth Analg. 1975;54:758–65.

    Article  CAS  PubMed  Google Scholar 

  10. Snow J. On the inhalation of the vapour of ether in surgical operations: containing a description of the various stages of etherization, and a statement of the result of nearly eighty operations in which ether has been employed in St. George’s and University College Hospitals. London: John Churchill; 1847. pp 1–88.

    Google Scholar 

  11. Snow J. On chloroform and other anaesthetics: their action and administration. John Churchill, New Burlington Street. London 1858. pp 1–443.

    Google Scholar 

  12. Guedel AE. Inhalation anesthesia: a fundamental guide. New York, Macmillan; 1937. pp 1–172

    Google Scholar 

  13. Cushing HW. Anaesthesia charts of 1895. Letter to F.A. Washburn. Treadwell Library, Massachusetts General Hospital, Boston, MA

    Google Scholar 

  14. Haggard AW. The absorption, distribution and elimination of ethyl ether. II. Analysis of the mechanism of absorption and elimination of such a gas or vapor as ethyl ether. J Biol Chem. 1924;59:753–96.

    CAS  Google Scholar 

  15. Haggard AW. The absorption, distribution and elimination of ethyl ether. III. The relation of the concentration of ether, or any similar volatile substance in the central nervous system to the concentration in the arterial blood and the buffer action of the body. J Biol Chem. 1924;59:797–832.

    Google Scholar 

  16. Kety SS. Theory and application of exchange of inert gas at the lungs and tissues. Pharmacol Rev. 1951;3:1–41.

    CAS  PubMed  Google Scholar 

  17. Severinghaus JW. The rate of uptake of nitrous oxide in man. J Clin Invest. 1954;33:1183–9.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  18. Lowe HJ, Ernst EA. The quantitative practice of anesthesia. Use of closed circuit. Baltimore, Williams & Wilkins; 1981. pp 1–234

    Google Scholar 

  19. Price HL. A dynamic concept of the distribution of thiopental in the human body. Anesthesiology. 1960;21:40–5.

    Article  CAS  PubMed  Google Scholar 

  20. Eger EI II. Anesthetic uptake and action. Baltimore, Williams & Wilkins; 1974. pp 1–371.

    Google Scholar 

  21. Eger EI II. A mathematical model of uptake and distribution. In: Papper EM, Kitz RJ, Editors. Uptake and distribution of anesthetic agents. New York, McGraw-Hill; 1963, pp 72–87.

    Google Scholar 

  22. Severinghaus JW. Role of lung factors. In: Papper EM, Kitz RJ, Editors. Uptake and distribution of anesthetic agents. New York, McGraw-Hill; 1963

    Google Scholar 

  23. Mapleson WW. Quantitative prediction of anesthetic concentrations. In: Papper EM, Kitz RJ, Editors. Uptake and distribution of anesthetic agents. New York, McGraw-Hill; 1963, pp 104–19.

    Google Scholar 

  24. Merkel G, Eger EI II. A comparative study of halothane and halopropane anesthesia. Including a method for determining equipotency. Anesthesiology. 1963;24:346–57.

    Article  CAS  PubMed  Google Scholar 

  25. Saidman LJ, Eger EI II. Effect of nitrous oxide and of narcotic premedication on the alveolar concentration of halothane required for anesthesia. Anesthesiology. 1964;25:302–6.

    Article  CAS  PubMed  Google Scholar 

  26. Andrews DT, Leslie K, Sessler DI, Bjorksten AR. The arterial blood propofol concentration preventing movement in 50% of healthy women after skin incision. Anesth Analg. 1997;85:414–9.

    CAS  PubMed  Google Scholar 

  27. Eger EI II, Eisenkraft JB, Weiskopf RB. The pharmacology of inhaled anesthetics. Chicago: Healthcare Press; 2002. pp 1–327.

    Google Scholar 

  28. Lawrie E. The Hyderbad chloroform commission. Lancet. 1889;1:952–3.

    Google Scholar 

  29. Embley EH. The causation of death during the administration of chloroform. Br Med J. 1902;2(2153):817–21.

    Article  Google Scholar 

  30. Embley EH. The causation of death during the administration of chloroform. Br Med J. 1902;2(2154):885–93.

    Article  Google Scholar 

  31. Embley EH. The causation of death during the administration of chloroform. Br Med J. 1902;1(2155):951–61.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  32. Beecher HK, Todd DP. A study of the deaths associated with anesthesia and surgery: based on a study of 599, 548 anesthesias in ten institutions 1948–1952, inclusive. Ann Surg. 1954;140:2–35.

    Article  CAS  PubMed  Google Scholar 

  33. Prescott F, Organe G, Rowbotham S. Tubocurarine as an adjunct to anaesthesia. Lancet. 1946;2:80–4.

    Article  CAS  PubMed  Google Scholar 

  34. Arbous MS, Meursing AE, Kleef JW van, Lange JJ de, Spoormans HH, Touw P, Werner FM, Grobbee DE. Impact of anesthesia management characteristics on severe morbidity and mortality. Anesthesiology. 2005;102:257–68.

    Article  PubMed  Google Scholar 

  35. Summary of the National Halothane Study. Possible association between halothane anesthesia and postoperative hepatic necrosis. Report by Subcommittee on the National Halothane Study of the Committee on Anesthesia, National Academy of Science. JAMA. 1966;197:775–88.

    Article  Google Scholar 

  36. Kurz A, Sessler DI, Lenhardt R. Perioperative normothermia to reduce the incidence of surgical-wound infection and shorten hospitalization. Study of Wound Infection and Temperature Group. N Engl J Med. 1996;334:1209–15.

    Article  CAS  PubMed  Google Scholar 

  37. Hopf HW, Hunt TK, West JM, Blomquist P, Goodson WH 3rd, Jensen JA, Jonsson K, Paty PB, Rabkin JM, Upton RA, Smitten K von, Whitney JD. Wound tissue oxygen tension predicts the risk of wound infection in surgical patients. Arch Surg. 1997;132:997–1004. (discussion 1005).

    Article  CAS  PubMed  Google Scholar 

  38. Wallace A, Layug B, Tateo I, Li J, Hollenberg M, Browner W, Miller D, Mangano D. Prophylactic atenolol reduces postoperative myocardial ischemia. McSPI Research Group. Anesthesiology. 1998;88:7–17.

    Article  CAS  PubMed  Google Scholar 

  39. Lassen HCA, Henriksen E, Neukirch F, Kristensen HS. Treatment of tetanus. Severe bone-marrow depression after prolonged nitrous-oxide anaesthesia. Lancet. 1956;1:527–30.

    Article  Google Scholar 

  40. Eger EI II, Editor. Nitrous Oxide/N2O. New York: Elsevier; 1985. pp 1–357.

    Google Scholar 

  41. Myles PS, Leslie K, Chan MT, Forbes A, Paech MJ, Peyton P, Silbert BS, Pascoe E. Avoidance of nitrous oxide for patients undergoing major surgery: a randomized controlled trial. Anesthesiology. 2007;107:221–31.

    Article  CAS  PubMed  Google Scholar 

  42. Myles PS, Chan MT, Leslie K, Peyton P, Paech M, Forbes A. Effect of nitrous oxide on plasma homocysteine and folate in patients undergoing major surgery. Br J Anaesth. 2008;100:780–6.

    Article  CAS  PubMed  Google Scholar 

  43. McGregor DG, Lanier WL, Pasternak JJ, Rusy DA, Hogan K, Samra S, Hindman B, Todd MM, Schroeder DR, Bayman EO, Clarke W, Torner J, Weeks J. Effect of nitrous oxide on neurologic and neuropsychological function after intracranial aneurysm surgery. Anesthesiology. 2008;108:568–79.

    Article  CAS  PubMed  Google Scholar 

  44. Meyer HH. Theorie der Alkoholnarkose. Arch Exptl Pathol Pharmakol. 1899;42:109–18.

    Article  Google Scholar 

  45. Overton E. Ueber die allgemeinen osmotischen Eigenschaften der Zelle, ihre vermutliche Ursachen und ihre Bedeutung fur die Physiologie. Vierteljahrschr Naturforsch Ges Zurich. 1899;44:88–114.

    Google Scholar 

  46. Franks NP, Lieb WR. Do general anaesthetics act by competitive binding to specific receptors? Nature. 1984;310:599–601.

    Article  CAS  PubMed  Google Scholar 

  47. Jurd R, Arras M, Lambert S, Drexler B, Siegwart R, Crestani F, Zaugg M, Vogt KE, Ledermann B, Antkowiak B, Rudolph U. General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit. FASEB J. 2003;17:250–2.

    CAS  PubMed  Google Scholar 

  48. Eger EI, II, Raines DE, Shafer SL, Hemmings HC Jr, Sonner JM. Is a new paradigm needed to explain how inhaled anesthetics produce immobility? Anesth Analg. 2008;107:832–48.

    Article  PubMed Central  PubMed  Google Scholar 

  49. Zhang Y, Sonner JM, Eger EI II, Stabernack CR, Laster MJ, Raines DE, Harris RA. GABAA receptors do not mediate the immobility produced by inhaled anesthetics. Anesth Analg. 2004;99:85–90.

    Article  CAS  PubMed  Google Scholar 

  50. Sonner JM, Werner DF, Elsen FP, Xing Y, Liao M, Harris RA, Harrison NL, Fanselow MS, Eger EI, 2nd, Homanics GE. Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gamma-aminobutyric acid type A receptors unresponsive to isoflurane. Anesthesiology. 2007;106:107–13.

    Article  CAS  PubMed  Google Scholar 

  51. Lichtenstein ME, Method H. Edmund Andrews, M.D., a biographical sketch with historical notes concerning nitrous oxide anesthesia. Q Bull Northwest Univ Med Sch. 1953;27(4):337–52.

    Google Scholar 

  52. Morris LE. A new vaporizer for liquid anesthetic agents. Anesthesiology. 1952;13:587–93.

    Article  CAS  PubMed  Google Scholar 

  53. Severinghaus JW, Bradley AF. Electrodes for blood pO2 and pCO2 determination. J Appl Physiol. 1958;13:515–20.

    CAS  PubMed  Google Scholar 

  54. Luft K. Über eine neue Methode der registrierenden Gasanalyse mit Hilfe der Absorption ultraroter Strahlen ohne spektrale Zerlegung. Ztschrf Techn Phys. 1943;24:97–104.

    CAS  Google Scholar 

  55. Severinghaus JW. Ozanne G: Multioperating room monitoring with one mass spectrometer. Acta Anaesthesiol Scand Suppl. 1978;70:186–7.

    CAS  PubMed  Google Scholar 

  56. Ozanne GM, Young WG, Mazzei WJ, Severinghaus JW. Multipatient anesthetic mass spectrometry: rapid analysis of data stored in long catheters. Anesthesiology. 1981;55:62–70.

    Article  CAS  PubMed  Google Scholar 

  57. Severinghaus JW. Gadgeteering for health care: the John W. Severinghaus lecture on translational science. Anesthesiology. 2009;110:721–8.

    Article  PubMed  Google Scholar 

  58. Spears RS Jr, Yeh A, Fisher DM, Zwass MS. The “educated hand”. Can anesthesiologists assess changes in neonatal pulmonary compliance manually? Anesthesiology. 1991;75:693–6.

    Article  PubMed  Google Scholar 

  59. Egbert LD, Bisno D. The educated hand of the anesthesiologist. A study of professional skill. Anesth Analg. 1967;46:195–200.

    Article  CAS  PubMed  Google Scholar 

  60. Oka Y. The evolution of intraoperative transesophageal echocardiography. Mt Sinai J Med. 2002;69:18–20.

    PubMed  Google Scholar 

  61. Millikan GA. The oximeter: an instrument for measuring continuously oxygen saturation of arterial blood in man. Rev Sci Instr. 1942;13:434–44.

    Article  CAS  Google Scholar 

  62. Wood EH, Geraci JE. Photoelectric determination of arterial oxygen saturation in man. J Lab Clin Med. 1949;34:387–401.

    CAS  PubMed  Google Scholar 

  63. Nakajima S, Hirai Y, Takase H. Performances of new pulse wave earpiece oximeter. Respir Circ. 1975;23:41–5.

    Google Scholar 

  64. Moller JT, Pedersen T, Rasmussen LS, Jensen PF, Pedersen BD, Ravlo O, Rasmussen NH, Espersen K, Johannessen NW, Cooper JB, et al. Randomized evaluation of pulse oximetry in 20,802 patients: I. Design, demography, pulse oximetry failure rate, and overall complication rate. Anesthesiology. 1993;78:436–44.

    Article  CAS  PubMed  Google Scholar 

  65. Eger EI II, Hamilton WK. Positive-negative pressure ventilation with a modified Ayre’s T-piece. Anesthesiology. 1958;19:611–8.

    Article  CAS  PubMed  Google Scholar 

  66. Schwinn DA, Balser JR. Anesthesiology physician scientists in academic medicine: a wake-up call. Anesthesiology. 2006;104:170–8.

    Article  PubMed Central  PubMed  Google Scholar 

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Acknowledgment

I thank Dr. John W. Severinghaus for his several suggestions.

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Authors and Affiliations

  1. Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA

    Edmond I Eger II MD

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  1. Edmond I Eger II MD
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Correspondence to Edmond I Eger II MD .

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Editors and Affiliations

  1. Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA, USA

    Edmond I Eger II MD Emeritus Professor

  2. Departments of Anesthesia, Stanford University, Stanford, CA, USA

    Lawrence J. Saidman MD Emeritus Professor

  3. Geoffrey Kaye Museum of Anaesthetic History, Australian and New Zealand College of Anaesthetists, Melbourne, VIC, Australia

    Rod N. Westhorpe OAM, MB, BS FRCA, FANZCA Former Honorary Curator

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© 2014 Edmond I Eger, MD

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Eger II, E. (2014). A History of Research in Anesthesia. In: Eger II, E., Saidman, L., Westhorpe, R. (eds) The Wondrous Story of Anesthesia. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8441-7_39

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  • DOI: https://doi.org/10.1007/978-1-4614-8441-7_39

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-8440-0

  • Online ISBN: 978-1-4614-8441-7

  • eBook Packages: MedicineMedicine (R0)

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