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Melt Extrusion pp 107-121 | Cite as

Properties and Applications of Hypromellose Acetate Succinate (HPMCAS) for Solubility Enhancement Using Melt Extrusion

Chapter
Part of the AAPS Advances in the Pharmaceutical Sciences Series book series (AAPS, volume 9)

Abstract

The development of bioavailable solid dispersions requires the use of secondary materials for stabilizing the amorphous dispersion while also enhancing dissolution and solubility of the new chemical entity. With the increased use of amorphous dispersions, hypromellose acetate succinate (HPMCAS) has emerged as a commonly used excipient for formulation design. This unique material, originally designed to enhance thermoplastic properties of cellulosics, can be used to enhance the solubility of many poorly soluble amorphous products. This chapter details the properties of HPMCAS that make it a beneficial material for use in solid dispersion formulation, with a specific focus on relevant properties for melt extrusion.

Keywords

Solid Dispersion Active Pharmaceutical Ingredient Extrusion Temperature Amorphous Solid Dispersion Cellulose Acetate Phthalate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© American Association of Pharmaceutical Scientists 2013

Authors and Affiliations

  1. 1.Specialty Chemicals Research CenterShin-Etsu Chemical Co., Ltd.NiigataJapan
  2. 2.Biomedical and Pharmaceutical SciencesUniversity of Rhode IslandKingstonUSA

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