Melt Extrusion pp 447-458 | Cite as

Melt Extrusion: A Commercial Perception to Practicality

Lessons Learned from Meltrex® Technology
Part of the AAPS Advances in the Pharmaceutical Sciences Series book series (AAPS, volume 9)


Over the past two decades, Meltrex® has evolved from being a novel processing technique into a comprehensive manufacturing technology. This chapter discusses the successful application of Meltrex® in the commercial development of delivery systems for varied drugs such as lopinavir (Kaletra®), ritonavir (Norvir®), ibuprofen, and verapamil hydrochloride (Isoptin®). Besides the commercial applications, Meltrex® can be successfully applied in design of solid dispersions (bioavailability enhancement of poorly soluble drugs), alter or control dissolution profiles (sustained release), reduced dosing frequency, deter substance abuse, improve safety, and efficacy of drugs. Moreover, continuous processing, rigorous and comprehensive regulatory documentation, and use of generally regarded as safe (GRAS) material are some of the striking features which make Meltrex® a popular drug delivery technology.


Solid Dispersion Area Under Curve Tablet Formulation Amorphous Solid Dispersion Sustained Release Formulation 
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Copyright information

© American Association of Pharmaceutical Scientists 2013

Authors and Affiliations

  1. 1.Department of Pharmaceutics, School of PharmacyThe University of MississippiUniversityUSA
  2. 2.Abbott GmbH & Co. KGLudwigshafenGermany

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