Abstract
This chapter first presents and discusses the physical phenomena taking place in both injection molding machines and the molds, which enable the injection molding process to produce shaped thermoplastic polymer products reproducibly, inexpensively and rapidly, with only minimum industrial waste stream. Industrial waste generated aside, it then addresses the question of whether the existing injection molding processes and equipment are appropriate for producing tablets of active pharmaceutical ingredient (API) solid solutions in polymer excipients, where the total dissolution of the API in the molten excipient, and the absence of API process-generated degradation must be guaranteed. The arguments presented indicate the need for specific modifications of the existing injection molding processes, which change and improve the melting and laminar mixing generated, to assure API dissolution, and decrease the chances of API degradation originating from the process.
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© 2013 American Association of Pharmaceutical Scientists
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Gogos, C. (2013). Excipient or API Melt Processing via Injection Molding. In: Repka, M., Langley, N., DiNunzio, J. (eds) Melt Extrusion. AAPS Advances in the Pharmaceutical Sciences Series, vol 9. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8432-5_11
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DOI: https://doi.org/10.1007/978-1-4614-8432-5_11
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