Tumors of the Hematopoietic System
Primary CNS lymphoma is actually one of the most frequent intracranial tumors, being non-Hodgkin diffuse large B-cell lymphoma the most prevalent type. They are not surgical diseases and even partial resection is associated with a dismal prognosis. Smears are recommended for intraoperative procedure. High-grade lymphomas show highly cellular smears with a single cell pattern of large atypical lymphoid cells. Low-grade lymphomas can easily be interpreted as being inflammatory or reactive in nature.