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Managing PCOS-Related Infertility: Ovulation Induction, In Vitro Fertilization, and In Vitro Maturation

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Polycystic Ovary Syndrome

Abstract

Polycystic ovarian syndrome (PCOS) is a complex endocrine disorder that affects up to 15 % of reproductive-age women. One of the hallmarks of the disorder is anovulation, making infertility an area of high concern within this population. Fortunately, there are several treatment options available to assist women with PCOS to achieve a healthy pregnancy. After exclusion of additional contributing factors to the infertility diagnosis, ovulation induction remains the mainstay in the management of PCOS-related infertility. For anovulatory women with excess body mass, weight loss is the most physiologic method to restore ovulatory cycles. When medical intervention is indicated, clomiphene citrate is considered the gold standard modality for ovulation induction, although aromatase inhibitors are increasingly being utilized in recent years. Alternative approaches include ovarian stimulation with the use of gonadotropins, in vitro fertilization (IVF), and, on an individualized basis, in vitro maturation (IVM). In patients with PCOS, the goal of all fertility treatment modalities is to achieve a singleton live birth, while protecting patient safety, limiting the potential risks of multiple pregnancies, and preventing ovarian hyperstimulation syndrome (OHSS).

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  1. Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA

    Saioa Torrealday M.D. & Pasquale Patrizio M.D., M.B.E.

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  1. Saioa Torrealday M.D.
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Correspondence to Pasquale Patrizio M.D., M.B.E. .

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  1. Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine Program for Polycystic Ovary Syndrome Yale Reproductive Endocrinology, New Haven, Connecticut, USA

    Lubna Pal

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Torrealday, S., Patrizio, P. (2014). Managing PCOS-Related Infertility: Ovulation Induction, In Vitro Fertilization, and In Vitro Maturation. In: Pal, L. (eds) Polycystic Ovary Syndrome. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8394-6_12

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-8393-9

  • Online ISBN: 978-1-4614-8394-6

  • eBook Packages: MedicineMedicine (R0)

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