Neuromodulators: Contemporary Indications and Techniques in the Upper and Midface
Early use of Botulinum toxin can be credited to ophthalmologist Dr. Allen Scott who communicated to the senior author and other in the late 1980s and early 1990s his observations of wrinkle effacement when treating blepharospasm. These observations led to early reports of Botulinum toxins employed to target specifically hyperfunctional frown lines. The great success of this molecule in aesthetic applications can thus be credited to the innovative thinking and initiative of clinicians with interest in advancing clinical care in contrast to the more common pharmaceutical-based, profit-motivated development of drugs and devices.
KeywordsBotulinum Toxin Botulinum Neurotoxin Orbicularis Oculus Frontalis Muscle Corrugator Muscle
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- 4.Mosby’s Medical Dictionary (8th ed. Elsevier; 2009).Google Scholar
- 8.Maas C, Kane MA, Bucay VW, Allen S, Applebaum DJ, Baumann L, Cox SE, Few JW, Joseph JH, Lorenc ZP, Moradi A, Nestor MS, Schlessinger J, Wortzman M, Lawrence I, Lin X, Nelson D. Current aesthetic use of abobotulinumtoxinA in clinical practice: an evidence-based consensus review. Aesthet Surg J. 2012;32(1 Suppl):8S–29.CrossRefPubMedGoogle Scholar