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Abstract

Pituitary adenomas are common intracranial tumors. Depending upon the underlying pituitary adenoma type, medical or surgical therapy is typically the initial treatment for patients with pituitary adenomas. However, these patients typically live long enough to require multiple treatments. Stereotactic radiosurgery is an important secondary or adjuvant treatment for these lesions. It can provide a high rate of tumor control and an opportunity for biochemical remission. Radiosurgery conveys a small risk of new or worsening neurological deficit or hypopituitarism.

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References

  1. Dekkers OM, Pereira AM, Romijn JA. Treatment and follow-up of clinically nonfunctioning pituitary macroadenomas. J Clin Endocrinol Metab. 2008;93(10):3717–26.

    Article  CAS  PubMed  Google Scholar 

  2. Vance ML. Treatment of patients with a pituitary adenoma: one clinician’s experience. Neurosurg Focus. 2004;16(4):1–6.

    Article  Google Scholar 

  3. Cushing H. The pituitary body and its disorders. Philadelphia: Lippincott; 1912.

    Google Scholar 

  4. Seymour ZA, Cohen-Gadol AA. Cushing’s lost cases of “radium bomb” brachytherapy for gliomas. J Neurosurg. 2010;113(1):141–8.

    Article  PubMed  Google Scholar 

  5. Schulder M, Loeffler JS, Howes AE, Alexander 3rd E, Black PM. Historical vignette: the radium bomb: Harvey Cushing and the interstitial irradiation of gliomas. J Neurosurg. 1996;84(3):530–2.

    Article  CAS  PubMed  Google Scholar 

  6. Leksell L. The stereotaxic method and radiosurgery of the brain. Acta Chir Scand. 1951;102(4):316–9.

    CAS  PubMed  Google Scholar 

  7. Barnett GH, Linskey ME, Adler JR, Cozzens JW, Friedman WA, Heilbrun MP, et al. Stereotactic radiosurgery—an organized neurosurgery-sanctioned definition. J Neurosurg. 2007;106(1):1–5.

    Article  PubMed  Google Scholar 

  8. Friedman WA, Foote KD. Linear accelerator radiosurgery in the management of brain tumours. Ann Med. 2000;32(1):64–80.

    Article  CAS  PubMed  Google Scholar 

  9. Chen CC, Chapman P, Petit J, Loeffler J. Proton radiosurgery in neurosurgery. Neurosurg Focus. 2007;23(6):E5.

    Article  PubMed  Google Scholar 

  10. Höybye C, Rähn T. Adjuvant gamma knife radiosurgery in non-functioning pituitary adenomas; low risk of long-term complications in selected patients. Pituitary. 2009;12(3):211–6.

    Article  PubMed  Google Scholar 

  11. Pan L, Zhang N, Wang E, Wang B, Xu W. Pituitary adenomas: the effect of gamma knife radiosurgery on tumor growth and endocrinopathies. Stereotact Funct Neurosurg. 1998;70 Suppl 1:119–26.

    Article  PubMed  Google Scholar 

  12. Feigl GC, Bonelli CM, Berghold A, Mokry M. Effects of gamma knife radiosurgery of pituitary adenomas on pituitary function. J Neurosurg. 2002;97(5 Suppl):415–21.

    PubMed  Google Scholar 

  13. Hayashi M, Izawa M, Hiyama H, Nakamura S, Atsuchi S, Sato H, et al. Gamma knife radiosurgery for pituitary adenomas. Stereotact Funct Neurosurg. 1999;72 Suppl 1:111–8.

    Article  PubMed  Google Scholar 

  14. Inoue HK, Kohga H, Hirato M, Sasaki T, Ishihara J, Shibazaki T, et al. Pituitary adenomas treated by microsurgery with or without gamma knife surgery: experience in 122 cases. Stereotact Funct Neurosurg. 1999;72 Suppl 1:125–31.

    Article  PubMed  Google Scholar 

  15. Izawa M, Hayashi M, Nakaya K, Satoh H, Ochiai T, Hori T, et al. Gamma knife radiosurgery for pituitary adenomas. J Neurosurg. 2000;93 Suppl 3:19–22.

    PubMed  Google Scholar 

  16. Kajiwara K, Saito K, Yoshikawa K, Kato S, Akimura T, Nomura S, et al. Image-guided stereotactic radiosurgery with the CyberKnife for pituitary adenomas. Minim Invasive Neurosurg. 2005;48(2):91–6.

    Article  CAS  PubMed  Google Scholar 

  17. Kobayashi T. Long-term results of stereotactic gamma knife radiosurgery for pituitary adenomas. Specific strategies for different types of adenoma. Prog Neurol Surg. 2009;22:77–95.

    Article  PubMed  Google Scholar 

  18. Lim YL, Leem W, Kim TS, Rhee BA, Kim GK. Four years’ experiences in the treatment of pituitary adenomas with gamma knife radiosurgery. Stereotact Funct Neurosurg. 1998;70 Suppl 1:95–109.

    Article  PubMed  Google Scholar 

  19. Liscak R, Vladyka V, Marek J, Simonova G, Vymazal J. Gamma knife radiosurgery for endocrine-inactive pituitary adenomas. Acta Neurochir (Wien). 2007;149(10):999–1006; discussion.

    Article  CAS  Google Scholar 

  20. Losa M, Valle M, Mortini P, Franzin A, da Passano CF, Cenzato M, et al. Gamma knife surgery for treatment of residual nonfunctioning pituitary adenomas after surgical debulking. J Neurosurg. 2004;100(3):438–44.

    Article  PubMed  Google Scholar 

  21. Martinez R, Bravo G, Burzaco J, Rey G. Pituitary tumors and gamma knife surgery. Clinical experience with more than two years of follow-up. Stereotact Funct Neurosurg. 1998;70 Suppl 1:110–8.

    Article  PubMed  Google Scholar 

  22. Mingione V, Yen CP, Vance ML, Steiner M, Sheehan J, Laws ER, et al. Gamma surgery in the treatment of nonsecretory pituitary macroadenoma. J Neurosurg. 2006;104(6):876–83.

    Article  PubMed  Google Scholar 

  23. Mitsumori M, Shrieve DC, Alexander 3rd E, Kaiser UB, Richardson GE, Black PM, et al. Initial clinical results of LINAC-based stereotactic radiosurgery and stereotactic radiotherapy for pituitary adenomas. Int J Radiat Oncol Biol Phys. 1998;42(3):573–80.

    Article  CAS  PubMed  Google Scholar 

  24. Mokry M, Ramschak-Schwarzer S, Simbrunner J, Ganz JC, Pendl G. A six year experience with the postoperative radiosurgical management of pituitary adenomas. Stereotact Funct Neurosurg. 1999;72 Suppl 1:88–100.

    Article  PubMed  Google Scholar 

  25. Muacevic A, Uhl E, Wowra B. Gamma knife radiosurgery for nonfunctioning pituitary adenomas. Acta Neurochir. 2004;91:51–4.

    CAS  Google Scholar 

  26. Muramatsu J, Yoshida M, Shioura H, Kawamura Y, Ito H, Takeuchi H, et al. [Clinical results of LINAC-based stereotactic radiosurgery for pituitary adenoma]. Nippon Igaku Hoshasen Gakkai Zasshi. 2003;63(5):225–30.

    PubMed  Google Scholar 

  27. Petrovich Z, Jozsef G, Yu C, Apuzzo ML. Radiotherapy and stereotactic radiosurgery for pituitary tumors. Neurosurg Clin N Am. 2003;14(1):147–66.

    Article  PubMed  Google Scholar 

  28. Picozzi P, Losa M, Mortini P, Valle MA, Franzin A, Attuati L, et al. Radiosurgery and the prevention of regrowth of incompletely removed nonfunctioning pituitary adenomas. J Neurosurg. 2005;102(Suppl):71–4.

    Article  PubMed  Google Scholar 

  29. Pollock BE, Cochran J, Natt N, Brown PD, Erickson D, Link MJ, et al. Gamma knife radiosurgery for patients with nonfunctioning pituitary adenomas: results from a 15-year experience. Int J Radiat Oncol Biol Phys. 2008;70(5):1325–9.

    Article  PubMed  Google Scholar 

  30. Sheehan JP, Kondziolka D, Flickinger J, Lunsford LD. Radiosurgery for residual or recurrent nonfunctioning pituitary adenoma. J Neurosurg. 2002;97(5 Suppl):408–14.

    PubMed  Google Scholar 

  31. Shin M, Kurita H, Sasaki T, Tago M, Morita A, Ueki K, et al. Stereotactic radiosurgery for pituitary adenoma invading the cavernous sinus. J Neurosurg. 2000;93 Suppl 3:2–5.

    PubMed  Google Scholar 

  32. Voges J, Kocher M, Runge M, Poggenborg J, Lehrke R, Lenartz D, et al. Linear accelerator radiosurgery for pituitary macroadenomas: a 7-year follow-up study. Cancer. 2006;107(6):1355–64.

    Article  PubMed  Google Scholar 

  33. Witt TC, Kondziolka D, Flickinger J, Lunsford LD. Gamma knife radiosurgery for pituitary tumors. In: Lunsford LD, Kondziolka D, Flickinger J, editors. Gamma knife brain surgery. Basel: Karger; 1998. p. 114–27.

    Chapter  Google Scholar 

  34. Wowra B, Stummer W. Efficacy of gamma knife radiosurgery for nonfunctioning pituitary adenomas: a quantitative follow up with magnetic resonance imaging-based volumetric analysis. J Neurosurg. 2002;97(5 Suppl):429–32.

    PubMed  Google Scholar 

  35. Yoon SC, Suh TS, Jang HS, Chung SM, Kim YS, Ryu MR, et al. Clinical results of 24 pituitary macroadenomas with linac-based stereotactic radiosurgery. Int J Radiat Oncol Biol Phys. 1998;41(4):849–53.

    Article  CAS  PubMed  Google Scholar 

  36. Starke RM, Williams BJ, Jane Jr JA, Sheehan JP. Gamma knife surgery for patients with nonfunctioning pituitary macroadenomas: predictors of tumor control, neurological deficits, and hypopituitarism. J Neurosurg. 2012;117(1):129–35.

    Article  PubMed  Google Scholar 

  37. Gopalan R, Schlesinger D, Vance ML, Laws E, Sheehan J. Long-term outcomes after gamma knife radiosurgery for patients with a nonfunctioning pituitary adenoma. Neurosurgery. 2011;69(2):284–93.

    Article  PubMed  Google Scholar 

  38. Biller BMK, Grossman AB, Stewart PM, Melmed S, Bertagna X, Bertherat J, et al. Treatment of adrenocorticotropin-dependent Cushing’s syndrome: a consensus statement. J Clin Endocrinol Metab. 2008;93(7):2454–62.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  39. Castinetti F, Nagai M, Dufour H, Kuhn JM, Morange I, Jaquet P, et al. Gamma knife radiosurgery is a successful adjunctive treatment in Cushing’s disease. Eur J Endocrinol. 2007;156(1):91–8.

    Article  CAS  PubMed  Google Scholar 

  40. Castinetti F, Nagai M, Morange I, Dufour H, Caron P, Chanson P, et al. Long-term results of stereotactic radiosurgery in secretory pituitary adenomas. J Clin Endocrinol Metab. 2009;94(9):3400–7.

    Article  CAS  PubMed  Google Scholar 

  41. Choi JY, Chang JH, Chang JW, Ha Y, Park YG, Chung SS. Radiological and hormonal responses of functioning pituitary adenomas after gamma knife radiosurgery. Yonsei Med J. 2003;44(4):602–7.

    Article  PubMed  Google Scholar 

  42. Degerblad M, Rahn T, Bergstrand G, Thoren M. Long-term results of stereotactic radiosurgery to the pituitary gland in Cushing’s disease. Acta Endocrinol. 1986;112(3):310–4.

    CAS  PubMed  Google Scholar 

  43. Devin JK, Allen GS, Cmelak AJ, Duggan DM, Blevins LS. The efficacy of linear accelerator radiosurgery in the management of patients with Cushing’s disease. Stereotact Funct Neurosurg. 2004;82(5–6):254–62.

    Article  PubMed  Google Scholar 

  44. Ganz JC, Backlund EO, Thorsen FA. The effects of gamma knife surgery of pituitary adenomas on tumor growth and endocrinopathies. Stereotact Funct Neurosurg. 1993;61 Suppl 1:30–7.

    PubMed  Google Scholar 

  45. Hoybye C, Grenback E, Rahn T, Degerblad M, Thoren M, Hulting AL. Adrenocorticotropic hormone-producing pituitary tumors: 12- to 22-year follow-up after treatment with stereotactic radiosurgery. Neurosurgery. 2001;49(2):284–91; discussion 91–2.

    Article  CAS  PubMed  Google Scholar 

  46. Jagannathan J, Sheehan JP, Pouratian N, Laws ER, Steiner L, Vance ML. Gamma knife surgery for Cushing’s disease. J Neurosurg. 2007;106(6):980–7.

    Article  PubMed  Google Scholar 

  47. Kajiwara K, Saito K, Yoshikawa K, Kato S, Akimura T, Nomura S, et al. Image-guided stereotactic radiosurgery with the CyberKnife for pituitary adenomas. Minim Invasive Neurosurg. 2005;48(2):91–6.

    Article  CAS  PubMed  Google Scholar 

  48. Kim SH, Huh R, Chang JW, Park YG, Chung SS. Gamma knife radiosurgery for functioning pituitary adenomas. Stereotact Funct Neurosurg. 1999;72 Suppl 1:101–10.

    Article  PubMed  Google Scholar 

  49. Kobayashi T, Kida Y, Mori Y. Gamma knife radiosurgery in the treatment of Cushing disease: long-term results. J Neurosurg. 2002;97(5 Suppl):422–8.

    PubMed  Google Scholar 

  50. Laws ER, Reitmeyer M, Thapar K, Vance ML. Cushing’s disease resulting from pituitary corticotrophic microadenoma. Treatment results from transsphenoidal microsurgery and gamma knife radiosurgery. Neurochirurgie. 2002;48(2–3 Pt 2):294–9.

    CAS  PubMed  Google Scholar 

  51. Levy RP, Fabrikant JI, Frankel KA, Phillips MH, Lyman JT, Lawrence JH, et al. Heavy-charged-particle radiosurgery of the pituitary gland: clinical results of 840 patients. Stereotact Funct Neurosurg. 1991;57(1–2):22–35.

    Article  CAS  PubMed  Google Scholar 

  52. Morange-Ramos I, Regis J, Dufour H, Andrieu JM, Grisoli F, Jaquet P, et al. Gamma-knife surgery for secreting pituitary adenomas. Acta Neurochir. 1998;140(5):437–43.

    Article  CAS  PubMed  Google Scholar 

  53. Petit JH, Biller BMK, Coen JJ, Swearingen B, Ancukiewicz M, Bussiere M, et al. Proton stereotactic radiosurgery in management of persistent acromegaly. Endocr Pract. 2007;13(7):726–34.

    Article  PubMed  Google Scholar 

  54. Pollock BE, Brown PD, Nippoldt TB, Young Jr WF. Pituitary tumor type affects the chance of biochemical remission after radiosurgery of hormone-secreting pituitary adenomas. Neurosurgery. 2008;62(6):1271–6; discussion 6–8.

    Article  PubMed  Google Scholar 

  55. Pollock BE, Nippoldt TB, Stafford SL, Foote RL, Abboud CF. Results of stereotactic radiosurgery in patients with hormone-producing pituitary adenomas: factors associated with endocrine normalization. J Neurosurg. 2002;97(3):525–30.

    Article  PubMed  Google Scholar 

  56. Seo Y, Fukuoka S, Takanashi M, Sasaki T, Suematsu K, Nakamura J. Gamma knife surgery for Cushing’s disease. Surg Neurol. 1995;43(2):170–6.

    Article  CAS  PubMed  Google Scholar 

  57. Sheehan JM, Vance ML, Sheehan JP, Ellegala DB, Laws Jr ER. Radiosurgery for Cushing’s disease after failed transsphenoidal surgery. J Neurosurg. 2000;93(5):738–42.

    Article  CAS  PubMed  Google Scholar 

  58. Tinnel BA, Henderson MA, Witt TC, Fakiris AJ, Worth RM, Des Rosiers PM, et al. Endocrine response after gamma knife-based stereotactic radiosurgery for secretory pituitary adenoma. Stereotact Funct Neurosurg. 2008;86(5):292–6.

    Article  PubMed  Google Scholar 

  59. Voges J, Kocher M, Runge M, Poggenborg J, Lehrke R, Lenartz D, et al. Linear accelerator radiosurgery for pituitary macroadenomas: a 7-year follow-up study. Cancer. 2006;107(6):1355–64.

    Article  PubMed  Google Scholar 

  60. Wan H, Chihiro O, Yuan S. MASEP gamma knife radiosurgery for secretory pituitary adenomas: experience in 347 consecutive cases. J Exp Clin Cancer Res. 2009;28:36.

    Article  PubMed Central  PubMed  Google Scholar 

  61. Witt TC. Stereotactic radiosurgery for pituitary tumors. Neurosurg Focus. 2003;14(5):e10.

    Article  PubMed  Google Scholar 

  62. Wong GK, Leung CH, Chiu KW, Ma R, Cockram CS, Lam MJ, et al. LINAC radiosurgery in recurrent Cushing’s disease after transsphenoidal surgery: a series of 5 cases. Minim Invasive Neurosurg. 2003;46(6):327–30.

    Article  CAS  PubMed  Google Scholar 

  63. Melmed S. Acromegaly. N Engl J Med. 2006;355(24):2558–73.

    Article  CAS  PubMed  Google Scholar 

  64. Attanasio R, Epaminonda P, Motti E, Giugni E, Ventrella L, Cozzi R, et al. Gamma-knife radiosurgery in acromegaly: a 4-year follow-up study. J Clin Endocrinol Metab. 2003;88(7):3105–12.

    Article  CAS  PubMed  Google Scholar 

  65. Castinetti F, Taieb D, Kuhn J-M, Chanson P, Tamura M, Jaquet P, et al. Outcome of gamma knife radiosurgery in 82 patients with acromegaly: correlation with initial hypersecretion. J Clin Endocrinol Metab. 2005;90(8):4483–8.

    Article  CAS  PubMed  Google Scholar 

  66. Fukuoka S, Ito T, Takanashi M, Hojo A, Nakamura H. Gamma knife radiosurgery for growth hormone-secreting pituitary adenomas invading the cavernous sinus. Stereotact Funct Neurosurg. 2001;76(3–4):213–7.

    Article  CAS  PubMed  Google Scholar 

  67. Ikeda H, Jokura H, Yoshimoto T. Transsphenoidal surgery and adjuvant gamma knife treatment for growth hormone-secreting pituitary adenoma. J Neurosurg. 2001;95(2):285–91.

    Article  CAS  PubMed  Google Scholar 

  68. Jagannathan J, Sheehan JP, Pouratian N, Laws Jr ER, Steiner L, Vance ML. Gamma knife radiosurgery for acromegaly: outcomes after failed transsphenoidal surgery. Neurosurgery. 2008;62(6):1262–9; discussion 9–70.

    Article  PubMed  Google Scholar 

  69. Jezkova J, Marek J, Hana V, Krsek M, Weiss V, Vladyka V, et al. Gamma knife radiosurgery for acromegaly—long-term experience. Clin Endocrinol (Oxf). 2006;64(5):588–95.

    Article  Google Scholar 

  70. Kobayashi T, Mori Y, Uchiyama Y, Kida Y, Fujitani S. Long-term results of gamma knife surgery for growth hormone-producing pituitary adenoma: is the disease difficult to cure? J Neurosurg. 2005;102(Suppl):119–23.

    Article  PubMed  Google Scholar 

  71. Landolt AM, Haller D, Lomax N, Scheib S, Schubiger O, Siegfried J, et al. Stereotactic radiosurgery for recurrent surgically treated acromegaly: comparison with fractionated radiotherapy. J Neurosurg. 1998;88(6):1002–8.

    Article  CAS  PubMed  Google Scholar 

  72. Laws Jr ER, Vance ML. Radiosurgery for pituitary tumors and craniopharyngiomas. Neurosurg Clin N Am. 1999;10(2):327–36.

    PubMed  Google Scholar 

  73. Losa M, Gioia L, Picozzi P, Franzin A, Valle M, Giovanelli M, et al. The role of stereotactic radiotherapy in patients with growth hormone-secreting pituitary adenoma. J Clin Endocrinol Metab. 2008;93(7):2546–52 [see comment].

    Article  CAS  PubMed  Google Scholar 

  74. Muramatsu J, Yoshida M, Shioura H, Kawamura Y, Ito H, Takeuchi H, et al. [Clinical results of LINAC-based stereotactic radiosurgery for pituitary adenoma]. Nihon Igaku Hoshasen Gakkai Zasshi. 2003;63(5):225–30.

    PubMed  Google Scholar 

  75. Pollock BE, Jacob JT, Brown PD, Nippoldt TB. Radiosurgery of growth hormone-producing pituitary adenomas: factors associated with biochemical remission. J Neurosurg. 2007;106(5):833–8.

    Article  CAS  PubMed  Google Scholar 

  76. Pollock BE, Nippoldt TB, Stafford SL, Foote RL, Abboud CF. Results of stereotactic radiosurgery in patients with hormone-producing pituitary adenomas: factors associated with endocrine normalization. J Neurosurg. 2002;97(3):525–30.

    Article  PubMed  Google Scholar 

  77. Thoren M, Rahn T, Guo WY, Werner S. Stereotactic radiosurgery with the cobalt-60 gamma unit in the treatment of growth hormone-producing pituitary tumors. Neurosurgery. 1991;29(5):663–8.

    Article  CAS  PubMed  Google Scholar 

  78. Vik-Mo EO, Oksnes M, Pedersen P-H, Wentzel-Larsen T, Rodahl E, Thorsen F, et al. Gamma knife stereotactic radiosurgery for acromegaly. Eur J Endocrinol. 2007;157(3):255–63.

    Article  CAS  PubMed  Google Scholar 

  79. Franzin A, Spatola G, Losa M, Picozzi P, Mortini P. Results of gamma knife radiosurgery in acromegaly. Int J Endocrinol. 2012;2012:342034.

    Article  PubMed Central  PubMed  Google Scholar 

  80. Sheehan JP, Pouratian N, Steiner L, Laws ER, Vance ML. Gamma knife surgery for pituitary adenomas: factors related to radiological and endocrine outcomes. J Neurosurg. 2011;114(2):303–9.

    Article  PubMed  Google Scholar 

  81. Landolt AM, Lomax N. Gamma knife radiosurgery for prolactinomas. J Neurosurg. 2000;93 Suppl 3:14–8.

    PubMed  Google Scholar 

  82. Pan L, Zhang N, Wang EM, Wang BJ, Dai JZ, Cai PW. Gamma knife radiosurgery as a primary treatment for prolactinomas. J Neurosurg. 2000;93 Suppl 3:10–3.

    PubMed  Google Scholar 

  83. Choi JY, Chang JH, Chang JW, Ha Y, Park YG, Chung SS. Radiological and hormonal responses of functioning pituitary adenomas after gamma knife radiosurgery. Yonsei Med J. 2003;44(4):602–7.

    Article  PubMed  Google Scholar 

  84. Pouratian N, Sheehan J, Jagannathan J, Laws Jr ER, Steiner L, Vance ML. Gamma knife radiosurgery for medically and surgically refractory prolactinomas. Neurosurgery. 2006;59(2):255–66; discussion −66.

    Article  PubMed  Google Scholar 

  85. Jezkova J, Hana V, Krsek M, Weiss V, Vladyka V, Liscak R, et al. Use of the Leksell gamma knife in the treatment of prolactinoma patients. Clin Endocrinol (Oxf). 2009;70(5):732–41.

    Article  Google Scholar 

  86. Kobayashi T. Long-term results of stereotactic gamma knife radiosurgery for pituitary adenomas. Specific strategies for different types of adenoma. Prog Neurol Surg. 2009;22:77–95.

    Article  PubMed  Google Scholar 

  87. Tanaka S, Link MJ, Brown PD, Stafford SL, Young Jr WF, Pollock BE. Gamma knife radiosurgery for patients with prolactin-secreting pituitary adenomas. World Neurosurg. 2010;74(1):147–52.

    Article  PubMed  Google Scholar 

  88. Sun DQ, Cheng JJ, Frazier JL, Batra S, Wand G, Kleinberg LR, et al. Treatment of pituitary adenomas using radiosurgery and radiotherapy: a single center experience and review of literature. Neurosurg Rev. 2011;34(2):181–9.

    Article  Google Scholar 

  89. Ma ZM, Qiu B, Hou YH, Liu YS. [Gamma knife treatment for pituitary prolactinomas]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006;31(5):714–6.

    PubMed  Google Scholar 

  90. Liu X, Kano H, Kondziolka D, Park KJ, Iyer A, Shin S, et al. Gamma knife stereotactic radiosurgery for drug resistant or intolerant invasive prolactinomas. Pituitary. 2013;16(1):68–75.

    Article  PubMed  Google Scholar 

  91. Jagannathan J, Yen C-P, Pouratian N, Laws ER, Sheehan JP. Stereotactic radiosurgery for pituitary adenomas: a comprehensive review of indications, techniques and long-term results using the gamma knife. J Neurooncol. 2009;92(3):345–56.

    Article  PubMed  Google Scholar 

  92. Landolt AM, Haller D, Lomax N, Scheib S, Schubiger O, Siegfried J, et al. Octreotide may act as a radioprotective agent in acromegaly. J Clin Endocrinol Metab. 2000;85(3):1287–9.

    Article  CAS  PubMed  Google Scholar 

  93. Taussky P, Kalra R, Coppens J, Mohebali J, Jensen R, Couldwell WT. Endocrinological outcome after pituitary transposition (hypophysopexy) and adjuvant radiotherapy for tumors involving the cavernous sinus. J Neurosurg. 2011;115(1):55–62.

    Article  PubMed  Google Scholar 

  94. Lim YJ, Leem W, Park JT, Kim TS, Rhee BA, Kim GK. Cerebral infarction with ICA occlusion after gamma knife radiosurgery for pituitary adenoma: a case report. Stereotact Funct Neurosurg. 1999;72 Suppl 1:132–9.

    Article  PubMed  Google Scholar 

  95. Loeffler JS, Niemierko A, Chapman PH. Second tumors after radiosurgery: tip of the iceberg or a bump in the road? Neurosurgery. 2003;52(6):1436–40; discussion 40–2.

    Article  PubMed  Google Scholar 

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Correspondence to Jason P. Sheehan M.D., Ph.D. .

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Sheehan, J.P., Williams, B. (2015). Stereotactic Radiosurgery for Pituitary Adenomas. In: Chin, L., Regine, W. (eds) Principles and Practice of Stereotactic Radiosurgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8363-2_26

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