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Laser Therapies: Cyclodestructive Procedures

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Surgical Innovations in Glaucoma

Abstract

Cyclodestructive procedures are usually reserved for cases of glaucoma that are refractory to medical therapy and outflow surgeries and in eyes that have little or no visual potential. Cyclodestruction has been carried out by various methods including surgical excision, diathermy, ultrasound, cryotherapy, and laser. Laser cyclophotocoagulation (CPC) has now become the principle method for surgically reducing aqueous inflow. The delivery of laser energy through the sclera may be performed by either the noncontact or contact method. In the noncontact approach, a slit lamp is employed to apply laser energy through the conjunctival/scleral surface. A contact lens is often applied to keep the eyelids open and blanch the conjunctiva. The focus of energy delivery is 1–1.5 mm behind the limbus and is offset from the aiming beam so that maximal therapeutic effect is at the level of the ciliary body. The potential benefits of the noncontact over the contact approach may include a more precise focus of laser energy on the ciliary body. More recently, contact CPC has gained favor as a preferred method for treating refractory cases of glaucoma.

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References

  1. Bietti G. Surgical intervention on the ciliary body; new trends for the relief of glaucoma. JAMA. 1950;142:889–97.

    Article  CAS  Google Scholar 

  2. Meyer SJ. Diathermy cauterization of ciliary body for glaucoma. Am J Ophthalmol. 1948;31:1540–6.

    CAS  Google Scholar 

  3. Weekers L, Weekers R. Nonperforating thermometric cyclodiathermy in treatment of hypertensive uveitis. Arch Ophthalmol. 1948;39:509–17.

    Article  CAS  Google Scholar 

  4. Walton DS, Grant WM. Penetrating cyclodiathermy for filtration. Arch Ophthalmol. 1970;83:47–8.

    Article  CAS  PubMed  Google Scholar 

  5. Coleman DJ, Lizzi FL, Driller J, et al. Therapeutic ultrasound in the treatment of glaucoma. I. Experimental model. Ophthalmology. 1985;92:339–46.

    Article  CAS  PubMed  Google Scholar 

  6. Wilensky JT. Staphyloma formation as a complication of ultrasound treatment in glaucoma. Arch Ophthalmol. 1985;103:1113.

    Article  CAS  PubMed  Google Scholar 

  7. Coleman DJ, Lizzi FL, Driller J, et al. Therapeutic ultrasound in the treatment of glaucoma. II. Clinical applications. Ophthalmology. 1985;92:347–53.

    Article  CAS  PubMed  Google Scholar 

  8. De Roetth Jr A. Cryosurgery for the treatment of advanced chronic simple glaucoma. Am J Ophthalmol. 1968;66:1034–41.

    PubMed  Google Scholar 

  9. De Roetth Jr A. Cryosurgery for the treatment of advanced chronic simple glaucoma. Trans Am Ophthalmol Soc. 1968;66:45–61.

    PubMed Central  PubMed  Google Scholar 

  10. Bellows AR, Grant WM. Cyclocryotherapy in advanced inadequately controlled glaucoma. Am J Ophthalmol. 1973;75:679–84.

    CAS  PubMed  Google Scholar 

  11. Bellows AR, Grant WM. Cyclocryotherapy of chronic open-angle glaucoma in aphakic eyes. Am J Ophthalmol. 1978;85:615–21.

    CAS  PubMed  Google Scholar 

  12. Caprioli J, Strang SL, Spaeth GL, Poryzees EH. Cyclocryotherapy in the treatment of advanced glaucoma. Ophthalmology. 1985;92:947–54.

    Article  CAS  PubMed  Google Scholar 

  13. Beckman H, Kinoshita A, Rota AN, Sugar HS. Transscleral ruby laser irradiation of the ciliary body in the treatment of intractable glaucoma. Trans Am Acad Ophthalmol Otolaryngol. 1972;76:423–36.

    CAS  PubMed  Google Scholar 

  14. Beckman H, Sugar HS. Neodymium laser cyclocoagulation. Arch Ophthalmol. 1973;90:27–8.

    Article  CAS  PubMed  Google Scholar 

  15. Devenyi RG, Trope GE, Hunter WH, Badeeb O. YAG transscleral cyclocoagulation in human eyes. Ophthalmology. 1987;94:1519–22.

    Article  CAS  PubMed  Google Scholar 

  16. Devenyi RG, Trope GE, Hunter WS. Neodymium-YAG transscleral cyclocoagulation in rabbit eyes. Br J Ophthalmol. 1987;71:441–4.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  17. McAllister J, O’Brien C. Neodymium: YAG transscleral cyclocoagulation: a clinical study. Eye (Lond). 1990;4(Pt 5):651–6.

    Article  Google Scholar 

  18. Hampton C, Shields MB, Miller KN, Blasini M. Evaluation of a protocol for transscleral neodymium: YAG cyclophotocoagulation in one hundred patients. Ophthalmology. 1990;97:910–7.

    Article  CAS  PubMed  Google Scholar 

  19. Wright MM, Grajewski AL, Feuer WJ. Nd:YAG cyclophotocoagulation: outcome of treatment for uncontrolled glaucoma. Ophthalmic Surg. 1991;22:279–83.

    CAS  PubMed  Google Scholar 

  20. Delgado MF, Dickens CJ, Iwach AG, et al. Long-term results of noncontact neodymium:yttrium-aluminum-garnet cyclophotocoagulation in neovascular glaucoma. Ophthalmology. 2003;110:895–9.

    Article  PubMed  Google Scholar 

  21. Lin P, Wollstein G, Glavas IP, Schuman JS. Contact transscleral neodymium:yttrium-aluminum-garnet laser cyclophotocoagulation long-term outcome. Ophthalmology. 2004;111:2137–43.

    Article  PubMed Central  PubMed  Google Scholar 

  22. Noureddin BN, Wilson-Holt N, Lavin M, et al. Advanced uncontrolled glaucoma. Nd:YAG cyclophotocoagulation or tube surgery. Ophthalmology. 1992;99:430–6; discussion 437.

    Article  CAS  PubMed  Google Scholar 

  23. Simmons RB, Shields MB, Blasini M, et al. Transscleral Nd:YAG laser cyclophotocoagulation with a contact lens. Am J Ophthalmol. 1991;15:671–7.

    Google Scholar 

  24. Echelman DA, Stern RA, Shields SR, et al. Variability of contact transscleral neodymium:YAG cyclophotocoagulation. Invest Ophthalmol Vis Sci. 1995;36:497–502.

    CAS  PubMed  Google Scholar 

  25. Shields MB, Shields SE. Noncontact transscleral Nd:YAG cyclophotocoagulation: a long-term follow-up of 500 patients. Trans Am Ophthalmol Soc. 1994;92:271–83; discussion 283–7.

    CAS  PubMed Central  PubMed  Google Scholar 

  26. Brancato R, Giovanni L, Trabucchi G, Pietroni C. Contact transscleral cyclophotocoagulation with Nd:YAG laser in uncontrolled glaucoma. Ophthalmic Surg. 1989;20:547–51.

    CAS  PubMed  Google Scholar 

  27. Schuman JS, Puliafito CA, Allingham RR, et al. Contact transscleral continuous wave neodymium:YAG laser cyclophotocoagulation. Ophthalmology. 1990;97:571–80.

    Article  CAS  PubMed  Google Scholar 

  28. Schuman JS, Jacobson JJ, Puliafito CA, et al. Experimental use of semiconductor diode laser in contact transscleral cyclophotocoagulation in rabbits. Arch Ophthalmol. 1990;108:1152–7.

    Article  CAS  PubMed  Google Scholar 

  29. Schuman JS, Bellows AR, Shingleton BJ, et al. Contact transscleral Nd:YAG laser cyclophotocoagulation. Midterm results. Ophthalmology. 1992;99:1089–94; discussion 1095.

    Article  CAS  PubMed  Google Scholar 

  30. Mankowska A, Zagorski Z, Kawa P, Mackiewicz J. Diode laser trans-scleral cyclo-photo-coagulation. Klin Oczna. 1999;101:103–4.

    CAS  PubMed  Google Scholar 

  31. Rotchford AP, Jayasawal R, Madhusudhan S, et al. Transscleral diode laser cycloablation in patients with good vision. Br J Ophthalmol. 2010;94:1180–3.

    Article  CAS  PubMed  Google Scholar 

  32. Spencer AF, Vernon SA. “Cyclodiode”: results of a standard protocol. Br J Ophthalmol. 1999;83:311–6.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  33. Pucci V, Tappainer F, Borin S, Bellucci R. Long-term follow-up after transscleral diode laser photocoagulation in refractory glaucoma. Ophthalmologica. 2003;217:279–83.

    Article  PubMed  Google Scholar 

  34. Schlote T, Grub M, Kynigopoulos M. Long-term results after transscleral diode laser cyclophotocoagulation in refractory posttraumatic glaucoma and glaucoma in aphakia. Graefes Arch Clin Exp Ophthalmol. 2008;246:405–10.

    Article  PubMed  Google Scholar 

  35. Leszczynski R, Gierek-Lapinska A, Forminska-Kapuscik M. Transscleral cyclophotocoagulation in the treatment of secondary glaucoma. Med Sci Monit. 2004;10:CR542–8.

    PubMed  Google Scholar 

  36. Murphy CC, Burnett CA, Spry PG, et al. A two centre study of the dose–response relation for transscleral diode laser cyclophotocoagulation in refractory glaucoma. Br J Ophthalmol. 2003;87:1252–7.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  37. Hauber FA, Scherer WJ. Influence of total energy delivery on success rate after contact diode laser transscleral cyclophotocoagulation: a retrospective case review and meta-analysis. J Glaucoma. 2002;11:329–33.

    Article  PubMed  Google Scholar 

  38. Noureddin BN, Zein W, Haddad C, et al. Diode laser transcleral cyclophotocoagulation for refractory glaucoma: a 1 year follow-up of patients treated using an aggressive protocol. Eye (Lond). 2006;20:329–35.

    Article  CAS  Google Scholar 

  39. Kosoko O, Gaasterland DE, Pollack IP, Enger CL. Long-term outcome of initial ciliary ablation with contact diode laser transscleral cyclophotocoagulation for severe glaucoma. The Diode Laser Ciliary Ablation Study Group. Ophthalmology. 1996;103:1294–302.

    Article  CAS  PubMed  Google Scholar 

  40. Ansari E, Gandhewar J. Long-term efficacy and visual acuity following transscleral diode laser photocoagulation in cases of refractory and non-refractory glaucoma. Eye (Lond). 2007;21:936–40.

    Article  CAS  Google Scholar 

  41. Youn J, Cox TA, Herndon LW, et al. A clinical comparison of transscleral cyclophotocoagulation with neodymium: YAG and semiconductor diode lasers. Am J Ophthalmol. 1998;126:640–7.

    Article  CAS  PubMed  Google Scholar 

  42. Lee PF. Argon laser photocoagulation of the ciliary processes in cases of aphakic glaucoma. Arch Ophthalmol. 1979;97:2135–8.

    Article  CAS  PubMed  Google Scholar 

  43. Lee PF, Shihab Z, Eberle M. Partial ciliary process laser photocoagulation in the management of glaucoma. Lasers Surg Med. 1980;1:85–92.

    Article  CAS  PubMed  Google Scholar 

  44. Uram M. Ophthalmic laser microendoscope ciliary process ablation in the management of neovascular glaucoma. Ophthalmology. 1992;99:1823–8.

    Article  CAS  PubMed  Google Scholar 

  45. Uram M. Combined phacoemulsification, endoscopic ciliary process photocoagulation, and intraocular lens implantation in glaucoma management. Ophthalmic Surg. 1995;26:346–52.

    CAS  PubMed  Google Scholar 

  46. Chen J, Cohn RA, Lin SC, et al. Endoscopic photocoagulation of the ciliary body for treatment of refractory glaucomas. Am J Ophthalmol. 1997;124:787–96.

    CAS  PubMed  Google Scholar 

  47. Gayton JL, Van Der Karr M, Sanders V. Combined cataract and glaucoma surgery: trabeculectomy versus endoscopic laser cycloablation. J Cataract Refract Surg. 1999;25:1214–9.

    Article  CAS  PubMed  Google Scholar 

  48. Lindfield D, Ritchie RW, Griffiths MF. “Phaco-ECP”: combined endoscopic cyclophotocoagulation and cataract surgery to augment medical control of glaucoma. BMJ Open. 2012;2:pii: e000578.

    Article  Google Scholar 

  49. Lima FE, Magacho L, Carvalho DM, et al. A prospective, comparative study between endoscopic cyclophotocoagulation and the Ahmed drainage implant in refractory glaucoma. J Glaucoma. 2004;13:233–7.

    Article  PubMed  Google Scholar 

  50. Neely DE, Plager DA. Endocyclophotocoagulation for management of difficult pediatric glaucomas. J AAPOS. 2001;5:221–9.

    Article  CAS  PubMed  Google Scholar 

  51. Plager DA, Neely DE. Intermediate-term results of endoscopic diode laser cyclophotocoagulation for pediatric glaucoma. J AAPOS. 1999;3:131–7.

    Article  CAS  PubMed  Google Scholar 

  52. Al-Haddad CE, Freedman SF. Endoscopic laser cyclophotocoagulation in pediatric glaucoma with corneal opacities. J AAPOS. 2007;11:23–8.

    Article  PubMed  Google Scholar 

  53. Carter BC, Plager DA, Neely DE, et al. Endoscopic diode laser cyclophotocoagulation in the management of aphakic and pseudophakic glaucoma in children. J AAPOS. 2007;11:34–40.

    Article  PubMed  Google Scholar 

  54. Egbert PR, Fiadoyor S, Budenz DL, et al. Diode laser transscleral cyclophotocoagulation as a primary surgical treatment for primary open-angle glaucoma. Arch Ophthalmol. 2001;119:345–50.

    Article  CAS  PubMed  Google Scholar 

  55. Kramp K, Vick HP, Guthoff R. Transscleral diode laser contact cyclophotocoagulation in the treatment of different glaucomas, also as primary surgery. Graefes Arch Clin Exp Ophthalmol. 2002;240:698–703.

    Article  PubMed  Google Scholar 

  56. Lai JS, Tham CC, Chan JC, Lam DS. Diode laser transscleral cyclophotocoagulation as primary surgical treatment for medically uncontrolled chronic angle closure glaucoma: long-term clinical outcomes. J Glaucoma. 2005;14:114–9.

    Article  PubMed  Google Scholar 

  57. Grueb M, Rohrbach JM, Bartz-Schmidt KU, Schlote T. Transscleral diode laser cyclophotocoagulation as primary and secondary surgical treatment in primary open-angle and pseudoexfoliative glaucoma. Long-term clinical outcomes. Graefes Arch Clin Exp Ophthalmol. 2006;244:1293–9.

    Article  PubMed  Google Scholar 

  58. Francis BA, Kawji AS, Vo NT, et al. Endoscopic cyclophotocoagulation (ECP) in the management of uncontrolled glaucoma with prior aqueous tube shunt. J Glaucoma. 2011;20:523–7.

    PubMed  Google Scholar 

  59. Bechrakis NE, Muller-Stolzenburg NW, Helbig H, Foerster MH. Sympathetic ophthalmia following laser cyclocoagulation. Arch Ophthalmol. 1994;112:80–4.

    Article  CAS  PubMed  Google Scholar 

  60. Edward DP, Brown SV, Higginbotham E, et al. Sympathetic ophthalmia following neodymium:YAG cyclotherapy. Ophthalmic Surg. 1989;20:544–6.

    CAS  PubMed  Google Scholar 

  61. Lam S, Tessler HH, Lam BL, Wilensky JT. High incidence of sympathetic ophthalmia after contact and noncontact neodymium:YAG cyclotherapy. Ophthalmology. 1992;99:1818–22.

    Article  CAS  PubMed  Google Scholar 

  62. Muqit MM, Menage MJ. Malignant glaucoma after phacoemulsification: treatment with diode laser cyclophotocoagulation. J Cataract Refract Surg. 2007;33:130–2.

    Article  PubMed  Google Scholar 

  63. Azuara-Blanco A, Dua HS. Malignant glaucoma after diode laser cyclophotocoagulation. Am J Ophthalmol. 1999;127:467–9.

    Article  CAS  PubMed  Google Scholar 

  64. Shen SY, Lai JS, Lam DS. Necrotizing scleritis following diode laser transscleral cyclophotocoagulation. Ophthalmic Surg Lasers Imaging. 2004;35:251–3.

    PubMed  Google Scholar 

  65. Ganesh SK, Rishi K. Necrotizing scleritis following diode laser trans-scleral cyclophotocoagulation. Indian J Ophthalmol. 2006;54:199–200.

    Article  PubMed  Google Scholar 

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Correspondence to Shan C. Lin MD .

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Kasuga, T., Huang, G., Lin, S.C. (2014). Laser Therapies: Cyclodestructive Procedures. In: Samples, J.R., Ahmed, I.I.K. (eds) Surgical Innovations in Glaucoma. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8348-9_9

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  • DOI: https://doi.org/10.1007/978-1-4614-8348-9_9

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