Skip to main content

Canaloplasty

  • Chapter
  • First Online:
Surgical Innovations in Glaucoma

Abstract

Canaloplasty is a non-penetrating glaucoma procedure that adopts an ab externo approach to improve aqueous outflow through the conventional pathway. Using a microcatheter with fiber-optic light guidance, a nonabsorbable suture is passed throughout the entire Schlemm’s canal and is tightened to put the trabecular meshwork on stretch, thereby maintaining canal patency and enhancing outflow. Potential complications are similar to those encountered in traditional penetrating procedures such as trabeculectomy, but given that no patent ostium or iridectomy is required, canaloplasty has lower risks of potentially devastating complications such as hypotony, choroidal effusion, or suprachoroidal hemorrhage. Studies have shown the efficacy of canaloplasty to be better than modest; thus, patients with mild to moderate open-angle glaucoma who require mid-teens target IOP are suitable candidates. Though a technically demanding procedure, canaloplasty’s excellent safety profile makes it a valuable surgical alternative in patients where early surgery is favorable and/or in high-risk cases.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 79.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Cairns JE. Trabeculectomy. Preliminary report of a new method. Am J Ophthalmol. 1968;66(4):673–9.

    CAS  PubMed  Google Scholar 

  2. Molteno AC. New implant for drainage in glaucoma. Clinical trial. Br J Ophthalmol. 1969;53(9):606–15.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. Krupin T, Podos SM, Becker B, Newkirk JB. Valve implants in filtering surgery. Am J Ophthalmol. 1976;81(2):232–5.

    CAS  PubMed  Google Scholar 

  4. Lloyd MA, Baerveldt G, Heuer DK, Minckler DS, Martone JF. Initial clinical experience with the baerveldt implant in complicated glaucomas. Ophthalmology. 1994;101(4):640–50.

    Article  CAS  PubMed  Google Scholar 

  5. Coleman AL, Hill R, Wilson MR, et al. Initial clinical experience with the Ahmed Glaucoma Valve implant. Am J Ophthalmol. 1995;120(1):23–31.

    CAS  PubMed  Google Scholar 

  6. Borisuth NS, Phillips B, Krupin T. The risk profile of glaucoma filtration surgery. Curr Opin Ophthalmol. 1999;10(2):112–6.

    Article  CAS  PubMed  Google Scholar 

  7. Gedde SJ, Herndon LW, Brandt JD, et al. Postoperative complications in the Tube Versus Trabeculectomy (TVT) study during five years of follow-up. Am J Ophthalmol. 2012;153(5):804–14.e1.

    Article  PubMed Central  PubMed  Google Scholar 

  8. Epstein E. Fibrosing response to aqueous. Its relation to glaucoma. Br J Ophthalmol. 1959;43:641–7.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  9. Krasnov MM. Externalization of Schlemm’s canal (sinusotomy) in glaucoma. Br J Ophthalmol. 1968;52(2):157–61.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  10. Hara T. Deep sclerectomy with Nd:YAG laser trabeculotomy ab interno: two-stage procedure. Ophthalmic Surg. 1988;19(2):101–6.

    CAS  PubMed  Google Scholar 

  11. Sanchez E, Schnyder CC, Sickenberg M, Chiou AG, Hediguer SE, Mermoud A. Deep sclerectomy: results with and without collagen implant. Int Ophthalmol. 1996;20(1–3):157–62.

    PubMed  Google Scholar 

  12. Stegmann R, Pienaar A, Miller D. Viscocanalostomy for open-angle glaucoma in black African patients. J Cataract Refract Surg. 1999;25(3):316–22.

    Article  CAS  PubMed  Google Scholar 

  13. Lewis RA, von Wolff K, Tetz M, et al. Canaloplasty: circumferential viscodilation and tensioning of Schlemm’s canal using a flexible microcatheter for the treatment of open-angle glaucoma in adults: interim clinical study analysis. J Cataract Refract Surg. 2007;33(7):1217–26.

    Article  PubMed  Google Scholar 

  14. Moses RA, Grodzki Jr WJ, Etheridge EL, Wilson CD. Schlemm’s canal: the effect of intraocular pressure. Invest Ophthalmol Vis Sci. 1981;20(1):61–8.

    CAS  PubMed  Google Scholar 

  15. Goldsmith JA, Ahmed IK, Crandall AS. Nonpenetrating glaucoma surgery. Ophthalmol Clin North Am. 2005;18(3):443–60, vii.

    Article  PubMed  Google Scholar 

  16. Smit BA, Johnstone MA. Effects of viscoelastic injection into Schlemm’s canal in primate and human eyes: potential relevance to viscocanalostomy. Ophthalmology. 2002;109(4):786–92.

    Article  PubMed  Google Scholar 

  17. Marchini G, Marraffa M, Brunelli C, Morbio R, Bonomi L. Ultrasound biomicroscopy and intraocular-pressure-lowering mechanisms of deep sclerectomy with reticulated hyaluronic acid implant. J Cataract Refract Surg. 2001;27(4):507–17.

    Article  CAS  PubMed  Google Scholar 

  18. Balazs EA, Denlinger JL. Clinical uses of hyaluronan. Ciba Found Symp. 1989;143:265–75; discussion 75–80, 81–5.

    CAS  PubMed  Google Scholar 

  19. Abdelrahman AM. Trabeculotome-guided deep sclerectomy. A pilot study. Am J Ophthalmol. 2005;140(1):152–4.

    Article  PubMed  Google Scholar 

  20. Argento C, Sanseau AC, Badoza D, Casiraghi J. Deep sclerectomy with a collagen implant using the excimer laser. J Cataract Refract Surg. 2001;27(4):504–6.

    Article  CAS  PubMed  Google Scholar 

  21. Verges C, Llevat E, Bardavio J. Laser-assisted deep sclerectomy. J Cataract Refract Surg. 2002;28(5):758–65.

    Article  PubMed  Google Scholar 

  22. Geffen N, Ton Y, Degani J, Assia EI. CO2 laser-assisted sclerectomy surgery, part II: multicenter clinical preliminary study. J Glaucoma. 2012;21(3):193–8.

    Article  PubMed  Google Scholar 

  23. Choudhary A, Wishart PK. Non-penetrating glaucoma surgery augmented with mitomycin C or 5-fluorouracil in eyes at high risk of failure of filtration surgery: long-term results. Clin Experiment Ophthalmol. 2007;35(4):340–7.

    Article  PubMed  Google Scholar 

  24. Barnebey HS. Canaloplasty with intraoperative low dosage mitomycin C: a retrospective case series. J Glaucoma. 2013;22(3):201–4.

    Article  PubMed  Google Scholar 

  25. Robert MC, Harasymowycz P. Hemorrhagic descemet detachment after combined canaloplasty and cataract surgery. Cornea. 2013;32(5):712–3.

    Article  PubMed  Google Scholar 

  26. Jaramillo A, Foreman J, Ayyala RS. Descemet membrane detachment after canaloplasty: incidence and management. J Glaucoma. 2012. Epub ahead of print.

    Google Scholar 

  27. Grieshaber MC, Schoetzau A, Flammer J, Orgul S. Postoperative microhyphema as a positive prognostic indicator in canaloplasty. Acta Ophthalmol. 2013;91(2):151–6.

    Article  CAS  PubMed  Google Scholar 

  28. Bull H, von Wolff K, Korber N, Tetz M. Three-year canaloplasty outcomes for the treatment of open-angle glaucoma: European study results. Graefes Arch Clin Exp Ophthalmol. 2011;249(10):1537–45.

    Article  PubMed  Google Scholar 

  29. Lewis RA, von Wolff K, Tetz M, et al. Canaloplasty: three-year results of circumferential viscodilation and tensioning of Schlemm canal using a microcatheter to treat open-angle glaucoma. J Cataract Refract Surg. 2011;37(4):682–90.

    Article  PubMed  Google Scholar 

  30. Grieshaber MC, Fraenkl S, Schoetzau A, Flammer J, Orgul S. Circumferential viscocanalostomy and suture canal distension (canaloplasty) for whites with open-angle glaucoma. J Glaucoma. 2011;20(5):298–302.

    Article  PubMed  Google Scholar 

  31. Shingleton B, Tetz M, Korber N. Circumferential viscodilation and tensioning of Schlemm canal (canaloplasty) with temporal clear corneal phacoemulsification cataract surgery for open-angle glaucoma and visually significant cataract: one-year results. J Cataract Refract Surg. 2008;34(3):433–40.

    Article  PubMed  Google Scholar 

  32. Grieshaber MC, Pienaar A, Olivier J, Stegmann R. Comparing two tensioning suture sizes for 360 degrees viscocanalostomy (canaloplasty): a randomised controlled trial. Eye (Lond). 2010;24(7):1220–6.

    Article  CAS  Google Scholar 

  33. Grieshaber MC, Pienaar A, Olivier J, Stegmann R. Canaloplasty for primary open-angle glaucoma: long-term outcome. Br J Ophthalmol. 2010;94(11):1478–82.

    Article  PubMed  Google Scholar 

  34. Fujita K, Kitagawa K, Ueta Y, Nakamura T, Miyakoshi A, Hayashi A. Short-term results of canaloplasty surgery for primary open-angle glaucoma in Japanese patients. Case Rep Ophthalmol. 2011;2(1):65–8.

    PubMed Central  PubMed  Google Scholar 

  35. Bindlish R, Condon GP, Schlosser JD, D’Antonio J, Lauer KB, Lehrer R. Efficacy and safety of mitomycin-C in primary trabeculectomy: five-year follow-up. Ophthalmology. 2002;109(7):1336–41; discussion 41–2.

    Article  PubMed  Google Scholar 

  36. Ayyala RS, Chaudhry AL, Okogbaa CB, Zurakowski D. Comparison of surgical outcomes between canaloplasty and trabeculectomy at 12 months’ follow-up. Ophthalmology. 2011;118(12):2427–33.

    Article  PubMed  Google Scholar 

  37. Koerber NJ. Canaloplasty in one eye compared with viscocanalostomy in the contralateral eye in patients with bilateral open-angle glaucoma. J Glaucoma. 2012;21(2):129–34.

    PubMed  Google Scholar 

  38. Lavin MJ, Wormald RP, Migdal CS, Hitchings RA. The influence of prior therapy on the success of trabeculectomy. Arch Ophthalmol. 1990;108(11):1543–8.

    Article  CAS  PubMed  Google Scholar 

  39. Migdal C, Gregory W, Hitchings R. Long-term functional outcome after early surgery compared with laser and medicine in open-angle glaucoma. Ophthalmology. 1994;101(10):1651–6; discussion 7.

    Article  CAS  PubMed  Google Scholar 

  40. Shaarawy T, Flammer J, Haefliger IO. Reducing intraocular pressure: is surgery better than drugs? Eye (Lond). 2004;18(12):1215–24.

    Article  CAS  Google Scholar 

  41. Nouri-Mahdavi K, Hoffman D, Coleman AL, et al. Predictive factors for glaucomatous visual field progression in the Advanced Glaucoma Intervention Study. Ophthalmology. 2004;111(9):1627–35.

    Article  PubMed  Google Scholar 

  42. Chiou AG, Mermoud A, Jewelewicz DA. Post-operative inflammation following deep sclerectomy with collagen implant versus standard trabeculectomy. Graefes Arch Clin Exp Ophthalmol. 1998;236(8):593–6.

    Article  CAS  PubMed  Google Scholar 

  43. Egrilmez S, Ates H, Nalcaci S, Andac K, Yagci A. Surgically induced corneal refractive change following glaucoma surgery: nonpenetrating trabecular surgeries versus trabeculectomy. J Cataract Refract Surg. 2004;30(6):1232–9.

    Article  PubMed  Google Scholar 

  44. Ahmed II, Khan BU. Non-penetrating glaucoma surgery. In: Yanoff M, Duker JS, editors. Ophthalmology. 3rd ed. Philadelphia: Mosby Elsevier; 2009. p. 1247–60.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Toby Yiu Bong Chan MD, FRCSC .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Science+Business Media New York

About this chapter

Cite this chapter

Chan, T.Y.B., Ahmed, I.I.K. (2014). Canaloplasty. In: Samples, J.R., Ahmed, I.I.K. (eds) Surgical Innovations in Glaucoma. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8348-9_14

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-8348-9_14

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-8347-2

  • Online ISBN: 978-1-4614-8348-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics