Perioral Dermatitis

  • Bryan Gammon
  • Bethanee J. Schlosser


Perioral dermatitis (PD), a common acneiform facial eruption, was first described in the 1950s. The terms “light-sensitive seborrheid” and “steroid-induced rosacea-like dermatitis” were previously used to describe this condition [1, 2]. Given the now recognized periorbital, perinasal, and perioral distribution of lesions, the term periorificial dermatitis may be most appropriate [3].


Placebo Burning Hydroxide Corticosteroid Fluoride 


  1. 1.
    Frumess GM, Lewis HM. Light-sensitive seborrheid. AMA Arch Dermatol. 1957; 75(2):245–8.CrossRefGoogle Scholar
  2. 2.
    Mihan R, Ayres Jr S. Perioral dermatitis. Arch Dermatol. 1964;89:803–5.PubMedCrossRefGoogle Scholar
  3. 3.
    Kihiczak GG, Cruz MA, Schwartz RA. Periorificial dermatitis in children: an update and description of a child with striking features. Int J Dermatol. 2009;48(3):304–6.PubMedCrossRefGoogle Scholar
  4. 4.
    Hafeez ZH. Perioral dermatitis: an update. Int J Dermatol. 2003;42(7):514–7.PubMedCrossRefGoogle Scholar
  5. 5.
    Dubus JC, Marguet C, Deschildre A, et al. Local side-effects of inhaled corticosteroids in asthmatic children: influence of drug, dose, age, and device. Allergy. 2001;56(10):944–8.PubMedCrossRefGoogle Scholar
  6. 6.
    Poulos GA, Brodell RT. Perioral dermatitis associated with an inhaled corticosteroid. Arch Dermatol. 2007;143(11):1460.PubMedCrossRefGoogle Scholar
  7. 7.
    Adams SJ, Davison AM, Cunliffe WJ, Giles GR. Perioral dermatitis in renal transplant recipients maintained on corticosteroids and immunosuppressive therapy. Br J Dermatol. 1982;106(5):589–92.PubMedCrossRefGoogle Scholar
  8. 8.
    Clementson B, Smidt AC. Periorificial dermatitis due to systemic corticosteroids in children: report of two cases. Pediatr Dermatol. 2012;29(3):331–2.PubMedCrossRefGoogle Scholar
  9. 9.
    Wilkinson DS, Kirton V, Wilkinson JD. Perioral dermatitis: a 12-year review. Br J Dermatol. 1979;101(3):245–57.PubMedCrossRefGoogle Scholar
  10. 10.
    Nguyen V, Eichenfield LF. Periorificial dermatitis in children and adolescents. J Am Acad Dermatol. 2006;55(5):781–5.PubMedCrossRefGoogle Scholar
  11. 11.
    Weston WL, Morelli JG. Identical twins with perioral dermatitis. Pediatr Dermatol. 1998;15(2):144.PubMedCrossRefGoogle Scholar
  12. 12.
    Nedorost ST. Medical pearl—the evaluation of perioral dermatitis: use of an extended patch test series. J Am Acad Dermatol. 2007;56(5 Suppl):S100–2.PubMedCrossRefGoogle Scholar
  13. 13.
    Arutjunow V. Perioral dermatitis—an allergic disease? Hautarzt. 1978;29(2):89–91.PubMedGoogle Scholar
  14. 14.
    Bradford LG, Montes LF. Perioral dermatitis and Candida albicans. Arch Dermatol. 1972; 105(6):892–5.PubMedCrossRefGoogle Scholar
  15. 15.
    Hsu CK, Hsu MM, Lee JY. Demodicosis: a clinicopathological study. J Am Acad Dermatol. 2009;60(3):453–62.PubMedCrossRefGoogle Scholar
  16. 16.
    Hogan DJ. Perioral dermatitis. Curr Probl Dermatol. 1995;22:98–104.PubMedGoogle Scholar
  17. 17.
    Urbatsch AJ, Frieden I, Williams ML, Elewski BE, Mancini AJ, Paller AS. Extrafacial and generalized granulomatous periorificial dermatitis. Arch Dermatol. 2002;138(10):1354–8.PubMedCrossRefGoogle Scholar
  18. 18.
    Hall CS, Reichenberg J. Evidence based review of perioral dermatitis therapy. G Ital Dermatol Venereol. 2010;145(4):433–44.PubMedGoogle Scholar
  19. 19.
    Weber K, Thurmayr R. Critical appraisal of reports on the treatment of perioral dermatitis. Dermatology. 2005;210(4):300–7.PubMedCrossRefGoogle Scholar
  20. 20.
    Miller SR, Shalita AR. Topical metronidazole gel (0.75%) for the treatment of perioral dermatitis in children. J Am Acad Dermatol. 1994;31(5 Pt 2):847–8.PubMedCrossRefGoogle Scholar
  21. 21.
    Veien NK, Munkvad JM, Nielsen AO, Niordson AM, Stahl D, Thormann J. Topical metronidazole in the treatment of perioral dermatitis. J Am Acad Dermatol. 1991;24(2 Pt 1):258–60.PubMedCrossRefGoogle Scholar
  22. 22.
    Bikowski JB. Topical therapy for perioral dermatitis. Cutis. 1983;31(6):678–82.PubMedGoogle Scholar
  23. 23.
    Weber K, Thurmayr R, Meisinger A. A topical erythromycin preparation and oral tetracycline for the treatment of perioral dermatitis: a placebo-controlled trial. J Dermatol Treat. 1993; 4:57–9.CrossRefGoogle Scholar
  24. 24.
    Weber K. How I, treat perioral dermatitis: non-compliance with the treatment guidelines. Dermatology. 2003;207(2):215.PubMedCrossRefGoogle Scholar
  25. 25.
    Oppel T, Pavicic T, Kamann S, Brautigam M, Wollenberg A. Pimecrolimus cream (1%) efficacy in perioral dermatitis—results of a randomized, double-blind, vehicle-controlled study in 40 patients. J Eur Acad Dermatol Venereol. 2007;21(9):1175–80.PubMedGoogle Scholar
  26. 26.
    Schwarz T, Kreiselmaier I, Bieber T, et al. A randomized, double-blind, vehicle-controlled study of 1% pimecrolimus cream in adult patients with perioral dermatitis. J Am Acad Dermatol. 2008;59(1):34–40.PubMedCrossRefGoogle Scholar
  27. 27.
    Macdonald A, Feiwel M. Perioral dermatitis: aetiology and treatment with tetracycline. Br J Dermatol. 1972;87(4):315–9.PubMedCrossRefGoogle Scholar
  28. 28.
    Misago N, Nakafusa J, Narisawa Y. Childhood granulomatous periorificial dermatitis: lupus miliaris disseminatus faciei in children? J Eur Acad Dermatol Venereol. 2005;19(4):470–3.PubMedCrossRefGoogle Scholar
  29. 29.
    Rosso JQ. Management of papulopustular rosacea and perioral dermatitis with emphasis on iatrogenic causation or exacerbation of inflammatory facial dermatoses: use of doxycycline-modified release 40mg capsule once daily in combination with properly selected skin care as an effective therapeutic approach. J Clin Aesthet Dermatol. 2011;4(8):20–30.PubMedGoogle Scholar
  30. 30.
    Jansen T. Azelaic acid as a new treatment for perioral dermatitis: results from an open study. Br J Dermatol. 2004;151(4):933–4.PubMedCrossRefGoogle Scholar
  31. 31.
    Jansen T, Melnik BC, Schadendorf D. Steroid-induced periorificial dermatitis in children–clinical features and response to azelaic acid. Pediatr Dermatol. 2010;27(2):137–42.PubMedCrossRefGoogle Scholar
  32. 32.
    Richey DF, Hopson B. Photodynamic therapy for perioral dermatitis. J Drugs Dermatol. 2006;5(2 Suppl):12–6.PubMedGoogle Scholar
  33. 33.
    Bendl BJ. Perioral dermatitis: etiology and treatment. Cutis. 1976;17(5):903–8.PubMedGoogle Scholar
  34. 34.
    Jansen T. Perioral dermatitis successfully treated with topical adapalene. J Eur Acad Dermatol Venereol. 2002;16(2):175–7.PubMedCrossRefGoogle Scholar
  35. 35.
    Smith KW. Perioral dermatitis with histopathologic features of granulomatous rosacea: successful treatment with isotretinoin. Cutis. 1990;46(5):413–5.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Bryan Gammon
    • 1
  • Bethanee J. Schlosser
    • 1
  1. 1.Department of DermatologyNorthwestern UniversityChicagoUSA

Personalised recommendations