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The Blood–Brain Barrier in Neuroinflammation

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Neuron-Glia Interaction in Neuroinflammation

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 7))

Abstract

The blood–brain barrier (BBB) is brain-specific capillary barrier that restricts the movement of soluble mediators and leukocytes from the blood to the central nervous system (CNS). The pathological breakdown of the BBB may be the initial key step of various neuroinflammatory CNS diseases including multiple sclerosis, bacterial meningitis, and neuroAIDS. This review describes an update of the biology of the cell comprising the BBB, and highlights the pathology and pathomechanisms of BBB breakdown in neuroinflammatory diseases. The human immortalized cell lines of BBB origin established in our laboratory will facilitate the future development of BBB research.

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Conflict of Interest

Fumitaka Shimizu declares that he has no conflict of interest. Takashi Kanda declares that he has no conflict of interest.

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Authors and Affiliations

  1. Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, 1-1-1, Minamikogushi, Ube, Yamaguchi, 7558505, Japan

    Fumitaka Shimizu M.D., Ph.D. & Takashi Kanda M.D., Ph.D.

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  1. Fumitaka Shimizu M.D., Ph.D.
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  2. Takashi Kanda M.D., Ph.D.
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Correspondence to Takashi Kanda M.D., Ph.D. .

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  1. Department of Neuroimmunology Research Inst. of Environmental Medicine, Nagoya University, Nagoya, Japan

    Akio Suzumura

  2. Div of Neurobiology & Neuroinformatics, National Inst of Physiological Science, Aichi, Japan

    Kazuhiro Ikenaka

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Shimizu, F., Kanda, T. (2013). The Blood–Brain Barrier in Neuroinflammation. In: Suzumura, A., Ikenaka, K. (eds) Neuron-Glia Interaction in Neuroinflammation. Advances in Neurobiology, vol 7. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8313-7_10

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