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Cell Adhesion During Drosophila Eye Development

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Molecular Genetics of Axial Patterning, Growth and Disease in the Drosophila Eye

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Abstract

Over a brief few days, thousands of cells in the Drosophila eye are organized to generate a precisely patterned functional organ. Eye morphogenesis requires coordinated cell fate specification and differentiation, local cell movements, niche acquisition, and apoptosis to remove surplus cells. The eye has provided a superb model tissue for studies of the molecular bases of these events and the past decade has been punctuated with studies on the adhesion molecules at play as the fly eye develops. Because of its structure—a neuroepithelium composed of several discrete and easily discernable cell types—the eye provides unique opportunities to examine the roles of adhesion between cells as a complex organ is generated. Indeed, dynamic adhesion plays a significant role in orchestrating, regulating, and driving eye morphogenesis.

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Acknowledgments

I am grateful to Mark Hellerman, Ursula Weber, and Jun Wu for very helpful comments on this chapter.

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Authors and Affiliations

  1. Biology Department, Wesleyan University, 06459, Middletown, CT, USA

    Ruth I. Johnson

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  1. Ruth I. Johnson
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Correspondence to Ruth I. Johnson .

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  1. Department of Biology, University of Dayton, Dayton, Ohio, USA

    Amit Singh

  2. Department of Biology Office: SC303C, University of Dayton, Dayton, Ohio, USA

    Madhuri Kango-Singh

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Johnson, R. (2013). Cell Adhesion During Drosophila Eye Development. In: Singh, A., Kango-Singh, M. (eds) Molecular Genetics of Axial Patterning, Growth and Disease in the Drosophila Eye. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8232-1_7

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