Skip to main content
SpringerLink
Log in

RIP1-Mediated Signaling Pathways in Cell Survival and Death Control

  • Chapter
  • First Online:
Necrotic Cell Death

Part of the book series: Cell Death in Biology and Diseases ((CELLDEATH))

Abstract

Receptor-interacting protein 1 (RIP1) is the founding member of the RIP family proteins that consist of seven members. Although it was initially found that RIP1 plays an important role in TNF receptor 1 (TNFR1)-mediated NF-κB activation that protects cells from apoptosis, later research found that RIP1 is also required for TNF-induced apoptosis and necrosis under certain conditions. In addition, RIP1 is also involved in signaling by other death receptors for FASL and TRAIL, and TLR and intracellular sensors/adaptors such as PIDD. When cells are responding to different stimulations or intracellular stresses such as DNA damage, RIP1 can transduce either pro-survival or pro-death signals. Thus, RIP1 plays a pivotal role in the decision of cells’ fate. In this chapter, recent reports on RIP1-mediated cell signaling with a focus on cell survival and death control will be summarized.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Arslan SC, Scheidereit C (2011) The prevalence of TNFalpha-induced necrosis over apoptosis is determined by TAK1-RIP1 interplay. PLoS One 6:e26069

    PubMed  CAS  Google Scholar 

  • Bai L, Chen W, Wang X, Ju W, Xu S, Lin Y (2009) Attenuating Smac mimetic compound 3-induced NF-kappaB activation by luteolin leads to synergistic cytotoxicity in cancer cells. J Cell Biochem 108:1125–1131

    PubMed Central  PubMed  CAS  Google Scholar 

  • Bai L, Xu S, Chen W, Li Z, Wang X, Tang H, Lin Y (2011) Blocking NF-kappaB and Akt by Hsp90 inhibition sensitizes Smac mimetic compound 3-induced extrinsic apoptosis pathway and results in synergistic cancer cell death. Apoptosis 16:45–54

    PubMed Central  PubMed  CAS  Google Scholar 

  • Barton GM, Kagan JC (2009) A cell biological view of Toll-like receptor function: regulation through compartmentalization. Nat Rev Immunol 9:535–542

    PubMed Central  PubMed  CAS  Google Scholar 

  • Bertrand MJ, Milutinovic S, Dickson KM, Ho WC, Boudreault A, Durkin J, Gillard JW, Jaquith JB, Morris SJ, Barker PA (2008) cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell 30:689–700

    PubMed  CAS  Google Scholar 

  • Biton S, Ashkenazi A (2011) NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-alpha feedforward signaling. Cell 145:92–103

    PubMed  CAS  Google Scholar 

  • Bonapace L, Bornhauser BC, Schmitz M, Cario G, Ziegler U, Niggli FK, Schafer BW, Schrappe M, Stanulla M, Bourquin JP (2010) Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance. J Clin Invest 120:1310–1323

    PubMed Central  PubMed  CAS  Google Scholar 

  • Byun HS, Park KA, Won M, Yang KJ, Shin S, Piao L, Kwak JY, Lee ZW, Park J, Seok JH, Liu ZG, Hur GM (2006) Phorbol 12-myristate 13-acetate protects against tumor necrosis factor (TNF)-induced necrotic cell death by modulating the recruitment of TNF receptor 1-associated death domain and receptor-interacting protein into the TNF receptor 1 signaling complex: Implication for the regulatory role of protein kinase C. Mol Pharmacol 70:1099–1108

    PubMed  CAS  Google Scholar 

  • Campbell KJ, Rocha S, Perkins ND (2004) Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B. Mol Cell 13:853–865

    PubMed  CAS  Google Scholar 

  • Chang M, Jin W, Sun SC (2009) Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. Nat Immunol 10:1089–1095

    PubMed Central  PubMed  CAS  Google Scholar 

  • Chen W, Wang X, Bai L, Liang X, Zhuang J, Lin Y (2008) Blockage of NF-kappaB by IKKbeta- or RelA-siRNA rather than the NF-kappaB super-suppressor IkappaBalpha mutant potentiates adriamycin-induced cytotoxicity in lung cancer cells. J Cell Biochem 105:554–561

    PubMed Central  PubMed  CAS  Google Scholar 

  • Cho YS, Challa S, Moquin D, Genga R, Ray TD, Guildford M, Chan FK (2009) Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 137:1112–1123

    PubMed Central  PubMed  CAS  Google Scholar 

  • Coupienne I, Fettweis G, Rubio N, Agostinis P, Piette J (2011) 5-ALA-PDT induces RIP3-dependent necrosis in glioblastoma. Photochem Photobiol Sci 10:1868–1878

    PubMed  CAS  Google Scholar 

  • Cusson-Hermance N, Khurana S, Lee TH, Fitzgerald KA, Kelliher MA (2005) Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation. J Biol Chem 280:36560–36566

    PubMed  CAS  Google Scholar 

  • Devin A, Cook A, Lin Y, Rodriguez Y, Kelliher M, Liu Z (2000) The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation. Immunity 12:419–429

    PubMed  CAS  Google Scholar 

  • Devin A, Lin Y, Liu ZG (2003) The role of the death-domain kinase RIP in tumour-necrosis-factor-induced activation of mitogen-activated protein kinases. EMBO Rep 4:623–627

    PubMed Central  PubMed  CAS  Google Scholar 

  • Dufour F, Bertrand L, Pearson A, Grandvaux N, Langelier Y (2011) The ribonucleotide reductase R1 subunits of herpes simplex virus 1 and 2 protect cells against poly(I. C)-induced apoptosis. J Virol 85:8689–8701

    PubMed Central  PubMed  CAS  Google Scholar 

  • Ea CK, Deng L, Xia ZP, Pineda G, Chen ZJ (2006) Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol Cell 22:245–257

    PubMed  CAS  Google Scholar 

  • Ermolaeva MA, Michallet MC, Papadopoulou N, Utermohlen O, Kranidioti K, Kollias G, Tschopp J, Pasparakis M (2008) Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses. Nat Immunol 9:1037–1046

    PubMed  CAS  Google Scholar 

  • Estornes Y, Toscano F, Virard F, Jacquemin G, Pierrot A, Vanbervliet B, Bonnin M, Lalaoui N, Mercier-Gouy P, Pacheco Y, Salaun B, Renno T, Micheau O, Lebecque S (2012) dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8. Cell Death Differ 19(9):1482–1494

    PubMed Central  PubMed  CAS  Google Scholar 

  • Fearns C, Pan Q, Mathison JC, Chuang TH (2006) Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding. J Biol Chem 281:34592–34600

    PubMed  CAS  Google Scholar 

  • Feoktistova M, Geserick P, Kellert B, Dimitrova DP, Langlais C, Hupe M, Cain K, MacFarlane M, Hacker G, Leverkus M (2011) cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell 43:449–463

    PubMed Central  PubMed  CAS  Google Scholar 

  • Festjens N, Vanden Berghe T, Cornelis S, Vandenabeele P (2007) RIP1, a kinase on the crossroads of a cell's decision to live or die. Cell Death Differ 14:400–410

    PubMed  CAS  Google Scholar 

  • Festjens N, Vanden Berghe T, Vandenabeele P (2006) Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response. Biochim Biophys Acta 1757:1371–1387

    PubMed  CAS  Google Scholar 

  • Fortes GB, Alves LS, de Oliveira R, Dutra FF, Rodrigues D, Fernandez PL, Souto-Padron T, De Rosa MJ, Kelliher M, Golenbock D, Chan FK, Bozza MT (2012) Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production. Blood 119:2368–2375

    PubMed Central  PubMed  CAS  Google Scholar 

  • Fujikura D, Ito M, Chiba S, Harada T, Perez F, Reed JC, Uede T, Miyazaki T (2012) CLIPR-59 regulates TNF-alpha-induced apoptosis by controlling ubiquitination of RIP1. Cell Death Dis 3:e264

    PubMed Central  PubMed  CAS  Google Scholar 

  • Ganapathi R, Vaziri SA, Tabata M, Takigawa N, Grabowski DR, Bukowski RM, Ganapathi MK (2002) Inhibition of NF-kappaB and proteasome activity in tumors: can we improve the therapeutic potential of topoisomerase I and topoisomerase II poisons. Curr Pharm Des 8:1945–1958

    PubMed  CAS  Google Scholar 

  • Habib AA, Chatterjee S, Park SK, Ratan RR, Lefebvre S, Vartanian T (2001) The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome. J Biol Chem 276:8865–8874

    PubMed  CAS  Google Scholar 

  • Han KJ, Su X, Xu LG, Bin LH, Zhang J, Shu HB (2004) Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways. J Biol Chem 279:15652–15661

    PubMed  CAS  Google Scholar 

  • He W, Wang Q, Xu J, Xu X, Padilla MT, Ren G, Gou X, Lin Y (2012) Attenuation of TNFSF10/TRAIL-induced apoptosis by an autophagic survival pathway involving TRAF2- and RIPK1/RIP1-mediated MAPK8/JNK activation. Autophagy 8:1811–1821

    Google Scholar 

  • He S, Wang L, Miao L, Wang T, Du F, Zhao L, Wang X (2009) Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell 137:1100–1111

    PubMed  CAS  Google Scholar 

  • He W, Wang Q, Srinivasan B, Xu J, Padilla MT, Li Z, Wang X, Liu Y, Gou X, Shen HM, Xing C, Lin Y (2013) A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy. Oncogene. Jul 13. [Epub ahead of print]

    Google Scholar 

  • Ho WC, Dickson KM, Barker PA (2005) Nuclear factor-kappaB induced by doxorubicin is deficient in phosphorylation and acetylation and represses nuclear factor-kappaB-dependent transcription in cancer cells. Cancer Res 65:4273–4281

    PubMed  CAS  Google Scholar 

  • Holler N, Zaru R, Micheau O, Thome M, Attinger A, Valitutti S, Bodmer JL, Schneider P, Seed B, Tschopp J (2000) Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol 1:489–495

    PubMed  CAS  Google Scholar 

  • Hsu H, Huang J, Shu HB, Baichwal V, Goeddel DV (1996) TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4:387–396

    PubMed  CAS  Google Scholar 

  • Huang TT, Wuerzberger-Davis SM, Wu ZH, Miyamoto S (2003) Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress. Cell 115:565–576

    PubMed  CAS  Google Scholar 

  • Hur GM, Kim YS, Won M, Choksi S, Liu ZG (2006) The death domain kinase RIP has an important role in DNA damage-induced, p53-independent cell death. J Biol Chem 281:25011–25017

    PubMed  CAS  Google Scholar 

  • Hur GM, Lewis J, Yang Q, Lin Y, Nakano H, Nedospasov S, Liu ZG (2003) The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation. Genes Dev 17:873–882

    PubMed Central  PubMed  CAS  Google Scholar 

  • Ikner A, Ashkenazi A (2011) TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8. J Biol Chem 286:21546–21554

    PubMed Central  PubMed  CAS  Google Scholar 

  • Jang MS, Lee SJ, Kang NS, Kim E (2011) Cooperative phosphorylation of FADD by Aur-A and Plk1 in response to taxol triggers both apoptotic and necrotic cell death. Cancer Res 71:7207–7215

    PubMed  CAS  Google Scholar 

  • Janssens S, Tinel A (2012) The PIDDosome, DNA-damage-induced apoptosis and beyond. Cell Death Differ 19:13–20

    PubMed Central  PubMed  CAS  Google Scholar 

  • Janssens S, Tinel A, Lippens S, Tschopp J (2005) PIDD mediates NF-kappaB activation in response to DNA damage. Cell 123:1079–1092

    PubMed  CAS  Google Scholar 

  • Janssens S, Tschopp J (2006) Signals from within: the DNA-damage-induced NF-kappaB response. Cell Death Differ 13:773–784

    PubMed  CAS  Google Scholar 

  • Jin Z, El-Deiry WS (2006) Distinct signaling pathways in TRAIL-versus tumor necrosis factor-induced apoptosis. Mol Cell Biol 26:8136–8148

    PubMed Central  PubMed  CAS  Google Scholar 

  • Ju W, Wang X, Shi H, Chen W, Belinsky SA, Lin Y (2007) A critical role of luteolin-induced reactive oxygen species in blockage of tumor necrosis factor-activated nuclear factor-kappaB pathway and sensitization of apoptosis in lung cancer cells. Mol Pharmacol 71:1381–1388

    PubMed  CAS  Google Scholar 

  • Kaiser WJ, Offermann MK (2005) Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif. J Immunol 174:4942–4952

    PubMed  CAS  Google Scholar 

  • Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M (2005) Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120:649–661

    PubMed  CAS  Google Scholar 

  • Kanayama A, Seth RB, Sun L, Ea CK, Hong M, Shaito A, Chiu YH, Deng L, Chen ZJ (2004) TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol Cell 15:535–548

    PubMed  CAS  Google Scholar 

  • Karin M, Gallagher E (2009) TNFR signaling: ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes. Immunol Rev 228:225–240

    PubMed  CAS  Google Scholar 

  • Karin M, Yamamoto Y, Wang QM (2004) The IKK NF-kappa B system: a treasure trove for drug development. Nat Rev Drug Discov 3:17–26

    PubMed  CAS  Google Scholar 

  • Kelliher MA, Grimm S, Ishida Y, Kuo F, Stanger BZ, Leder P (1998) The death domain kinase RIP mediates the TNF-induced NF-kappaB signal. Immunity 8:297–303

    PubMed  CAS  Google Scholar 

  • Kim YS, Morgan MJ, Choksi S, Liu ZG (2007) TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death. Mol Cell 26:675–687

    PubMed  CAS  Google Scholar 

  • Klein Klouwenberg P, Tan L, Werkman W, van Bleek GM, Coenjaerts F (2009) The role of Toll-like receptors in regulating the immune response against respiratory syncytial virus. Crit Rev Immunol 29:531–550

    PubMed  Google Scholar 

  • Knox PG, Davies CC, Ioannou M, Eliopoulos AG (2011) The death domain kinase RIP1 links the immunoregulatory CD40 receptor to apoptotic signaling in carcinomas. J Cell Biol 192:391–399

    PubMed Central  PubMed  CAS  Google Scholar 

  • Kobayashi K, Inohara N, Hernandez LD, Galan JE, Nunez G, Janeway CA, Medzhitov R, Flavell RA (2002) RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 416:194–199

    PubMed  CAS  Google Scholar 

  • Kreuzaler P, Watson CJ (2012) Killing a cancer: what are the alternatives? Nat Rev Cancer 12(6):411–424

    PubMed  CAS  Google Scholar 

  • Laukens B, Jennewein C, Schenk B, Vanlangenakker N, Schier A, Cristofanon S, Zobel K, Deshayes K, Vucic D, Jeremias I, Bertrand MJ, Vandenabeele P, Fulda S (2011) Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor alpha-induced necroptosis. Neoplasia 13:971–979

    PubMed Central  PubMed  CAS  Google Scholar 

  • Lee CT, Seol JY, Lee SY, Park KH, Han SJ, Yoo CG, Han SK, Shim YS, Kim YW (2003) The effect of adenovirus-IkappaBalpha transduction on the chemosensitivity of lung cancer cell line with resistance to cis-diamminedichloroplatinum(II)(cisplatin) and doxorubicin(adriamycin). Lung Cancer 41:199–206

    PubMed  Google Scholar 

  • Lee KG, Xu S, Kang ZH, Huo J, Huang M, Liu D, Takeuchi O, Akira S, Lam KP (2012) Bruton’s tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response. Proc Natl Acad Sci U S A 109:5791–5796

    PubMed Central  PubMed  CAS  Google Scholar 

  • Legarda-Addison D, Hase H, O’Donnell MA, Ting AT (2009) NEMO/IKKgamma regulates an early NF-kappaB-independent cell-death checkpoint during TNF signaling. Cell Death Differ 16:1279–1288

    PubMed Central  PubMed  CAS  Google Scholar 

  • Lewis J, Devin A, Miller A, Lin Y, Rodriguez Y, Neckers L, Liu ZG (2000) Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activation. J Biol Chem 275:10519–10526

    PubMed  CAS  Google Scholar 

  • Lin A, Dibling B (2002) The true face of JNK activation in apoptosis. Aging Cell 1:112–116

    PubMed  CAS  Google Scholar 

  • Lin Y, Bai L, Chen W, Xu S (2010) The NF-kappaB activation pathways, emerging molecular targets for cancer prevention and therapy. Expert Opin Ther Targets 14:45–55

    PubMed Central  PubMed  CAS  Google Scholar 

  • Lin Y, Choksi S, Shen HM, Yang QF, Hur GM, Kim YS, Tran JH, Nedospasov SA, Liu ZG (2004) Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation. J Biol Chem 279:10822–10828

    PubMed  CAS  Google Scholar 

  • Lin Y, Devin A, Cook A, Keane MM, Kelliher M, Lipkowitz S, Liu ZG (2000) The death domain kinase RIP is essential for TRAIL (Apo2L)-induced activation of IkappaB kinase and c-Jun N-terminal kinase. Mol Cell Biol 20:6638–6645

    PubMed Central  PubMed  CAS  Google Scholar 

  • Lin Y, Devin A, Rodriguez Y, Liu ZG (1999) Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev 13:2514–2526

    PubMed Central  PubMed  CAS  Google Scholar 

  • Lin Y, Yang Q, Wang X, Liu ZG (2006) The essential role of the death domain kinase receptor-interacting protein in insulin growth factor-I-induced c-Jun N-terminal kinase activation. J Biol Chem 281:23525–23532

    PubMed  CAS  Google Scholar 

  • Loder S, Fakler M, Schoeneberger H, Cristofanon S, Leibacher J, Vanlangenakker N, Bertrand MJ, Vandenabeele P, Jeremias I, Debatin KM, Fulda S (2012) RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis. Leukemia 26:1020–1029

    PubMed  CAS  Google Scholar 

  • Ma Y, Temkin V, Liu H, Pope RM (2005) NF-kappaB protects macrophages from lipopolysaccharide-induced cell death: the role of caspase 8 and receptor-interacting protein. J Biol Chem 280:41827–41834

    PubMed  CAS  Google Scholar 

  • Mabb AM, Wuerzberger-Davis SM, Miyamoto S (2006) PIASy mediates NEMO sumoylation and NF-kappaB activation in response to genotoxic stress. Nat Cell Biol 8:986–993

    PubMed  CAS  Google Scholar 

  • Mack C, Sickmann A, Lembo D, Brune W (2008) Inhibition of proinflammatory and innate immune signaling pathways by a cytomegalovirus RIP1-interacting protein. Proc Natl Acad Sci U S A 105:3094–3099

    PubMed Central  PubMed  CAS  Google Scholar 

  • Meylan E, Burns K, Hofmann K, Blancheteau V, Martinon F, Kelliher M, Tschopp J (2004) RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat Immunol 5:503–507

    PubMed  CAS  Google Scholar 

  • Meylan E, Tschopp J (2005) The RIP kinases: crucial integrators of cellular stress. Trends Biochem Sci 30:151–159

    PubMed  CAS  Google Scholar 

  • Micheau O, Tschopp J (2003) Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114:181–190

    PubMed  CAS  Google Scholar 

  • Mizushima N, Komatsu M (2011) Autophagy: renovation of cells and tissues. Cell 147:728–741

    PubMed  CAS  Google Scholar 

  • O'Donnell MA, Ting AT (2011) RIP1 comes back to life as a cell death regulator in TNFR1 signaling. FEBS J 278:877–887

    PubMed Central  PubMed  Google Scholar 

  • Osborn SL, Diehl G, Han SJ, Xue L, Kurd N, Hsieh K, Cado D, Robey EA, Winoto A (2010) Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis. Proc Natl Acad Sci U S A 107:13034–13039

    PubMed Central  PubMed  CAS  Google Scholar 

  • Park J, Kanayama A, Yamamoto K, Miyamoto Y (2012) ARD1 binding to RIP1 mediates doxorubicin-induced NF-kappaB activation. Biochem Biophys Res Commun 422(2):291–297

    PubMed  CAS  Google Scholar 

  • Park S, Ramnarain DB, Hatanpaa KJ, Mickey BE, Saha D, Paulmurugan R, Madden CJ, Wright PS, Bhai S, Ali MA, Puttaparthi K, Hu W, Elliott JL, Stuve O, Habib AA (2008) The death domain-containing kinase RIP1 regulates p27(Kip1) levels through the PI3K-Akt-forkhead pathway. EMBO Rep 9:766–773

    PubMed Central  PubMed  CAS  Google Scholar 

  • Park S, Zhao D, Hatanpaa KJ, Mickey BE, Saha D, Boothman DA, Story MD, Wong ET, Burma S, Georgescu MM, Rangnekar VM, Chauncey SS, Habib AA (2009) RIP1 activates PI3K-Akt via a dual mechanism involving NF-kappaB-mediated inhibition of the mTOR-S6K-IRS1 negative feedback loop and down-regulation of PTEN. Cancer Res 69:4107–4111

    PubMed Central  PubMed  CAS  Google Scholar 

  • Pobezinskaya YL, Kim YS, Choksi S, Morgan MJ, Li T, Liu C, Liu Z (2008) The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors. Nat Immunol 9:1047–1054

    PubMed Central  PubMed  CAS  Google Scholar 

  • Rocha S, Garrett MD, Campbell KJ, Schumm K, Perkins ND (2005) Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor. EMBO J 24:1157–1169

    PubMed Central  PubMed  CAS  Google Scholar 

  • Ruckdeschel K, Pfaffinger G, Haase R, Sing A, Weighardt H, Hacker G, Holzmann B, Heesemann J (2004) Signaling of apoptosis through TLRs critically involves toll/IL-1 receptor domain-containing adapter inducing IFN-beta, but not MyD88, in bacteria-infected murine macrophages. J Immunol 173:3320–3328

    PubMed  CAS  Google Scholar 

  • Sato T, Machida T, Takahashi S, Murase K, Kawano Y, Hayashi T, Iyama S, Takada K, Kuribayashi K, Sato Y, Kobune M, Takimoto R, Matsunaga T, Kato J, Niitsu Y (2008) Apoptosis supercedes necrosis in mitochondrial DNA-depleted Jurkat cells by cleavage of receptor-interacting protein and inhibition of lysosomal cathepsin. J Immunol 181:197–207

    PubMed  CAS  Google Scholar 

  • Shembade N, Harhaj NS, Parvatiyar K, Copeland NG, Jenkins NA, Matesic LE, Harhaj EW (2008) The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20. Nat Immunol 9:254–262

    PubMed  CAS  Google Scholar 

  • Shen HM, Lin Y, Choksi S, Tran J, Jin T, Chang L, Karin M, Zhang J, Liu ZG (2004) Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death. Mol Cell Biol 24:5914–5922

    PubMed Central  PubMed  CAS  Google Scholar 

  • Skaug B, Jiang X, Chen ZJ (2009) The role of ubiquitin in NF-kappaB regulatory pathways. Annu Rev Biochem 78:769–796

    PubMed  CAS  Google Scholar 

  • Stanger BZ, Leder P, Lee TH, Kim E, Seed B (1995) RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell 81:513–523

    PubMed  CAS  Google Scholar 

  • Sun L, Wang H, Wang Z, He S, Chen S, Liao D, Wang L, Yan J, Liu W, Lei X, Wang X (2012) Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 148:213–227

    PubMed  CAS  Google Scholar 

  • Tenev T, Bianchi K, Darding M, Broemer M, Langlais C, Wallberg F, Zachariou A, Lopez J, MacFarlane M, Cain K, Meier P (2011) The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol Cell 43:432–448

    PubMed  CAS  Google Scholar 

  • Tinel A, Janssens S, Lippens S, Cuenin S, Logette E, Jaccard B, Quadroni M, Tschopp J (2007) Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway. EMBO J 26:197–208

    PubMed Central  PubMed  CAS  Google Scholar 

  • Ting AT, Pimentel-Muinos FX, Seed B (1996) RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis. EMBO J 15:6189–6196

    PubMed Central  PubMed  CAS  Google Scholar 

  • Todde V, Veenhuis M, van der Klei IJ (2009) Autophagy: principles and significance in health and disease. Biochim Biophys Acta 1792:3–13

    PubMed  CAS  Google Scholar 

  • Upton JW, Kaiser WJ, Mocarski ES (2008) Cytomegalovirus M45 cell death suppression requires receptor-interacting protein (RIP) homotypic interaction motif (RHIM)-dependent interaction with RIP1. J Biol Chem 283:16966–16970

    PubMed Central  PubMed  CAS  Google Scholar 

  • Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G (2010) Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol 11:700–714

    PubMed  CAS  Google Scholar 

  • Vanlangenakker N, Bertrand MJ, Bogaert P, Vandenabeele P, Vanden Berghe T (2011a) TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members. Cell Death Dis 2:e230

    PubMed Central  PubMed  CAS  Google Scholar 

  • Vanlangenakker N, Vanden Berghe T, Bogaert P, Laukens B, Zobel K, Deshayes K, Vucic D, Fulda S, Vandenabeele P, Bertrand MJ (2011b) cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production. Cell Death Differ 18:656–665

    PubMed Central  PubMed  CAS  Google Scholar 

  • Ventura JJ, Cogswell P, Flavell RA, Baldwin AS Jr, Davis RJ (2004) JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. Genes Dev 18:2905–2915

    PubMed Central  PubMed  CAS  Google Scholar 

  • Vivarelli MS, McDonald D, Miller M, Cusson N, Kelliher M, Geha RS (2004) RIP links TLR4 to Akt and is essential for cell survival in response to LPS stimulation. J Exp Med 200(3):399–404

    PubMed Central  PubMed  CAS  Google Scholar 

  • Wagner L, Marschall V, Karl S, Cristofanon S, Zobel K, Deshayes K, Vucic D, Debatin KM, Fulda S (2012) Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-kappaB-dependent manner. Oncogene 32:988–997

    PubMed  Google Scholar 

  • Wang L, Du F, Wang X (2008) TNF-alpha induces two distinct caspase-8 activation pathways. Cell 133:693–703

    PubMed  CAS  Google Scholar 

  • Wang Q, Chen W, Bai L, Chen W, Padilla MT, AS Lin, Shi S, Wang X. Lin Y (2014) Receptor-interacting protein 1 increases chemoresistance by maintaining inhibitor of apoptosis protein levels and reducing reactive oxygen species through a microRNA-146a-mediated catalase pathway. J Biol Chem. Jan 14 [Epub ahead of print]

    Google Scholar 

  • Wang S, Kotamraju S, Konorev E, Kalivendi S, Joseph J, Kalyanaraman B (2002) Activation of nuclear factor-kappaB during doxorubicin-induced apoptosis in endothelial cells and myocytes is pro-apoptotic: the role of hydrogen peroxide. Biochem J 367:729–740

    PubMed Central  PubMed  CAS  Google Scholar 

  • Wang X, Ju W, Renouard J, Aden J, Belinsky SA, Lin Y (2006) 17-allylamino-17-demethoxygeldanamycin synergistically potentiates tumor necrosis factor-induced lung cancer cell death by blocking the nuclear factor-kappaB pathway. Cancer Res 66:1089–1095

    PubMed  CAS  Google Scholar 

  • Wang Z, Jiang H, Chen S, Du F, Wang X (2012) The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 148:228–243

    PubMed  CAS  Google Scholar 

  • Wong WW, Gentle IE, Nachbur U, Anderton H, Vaux DL, Silke J (2010) RIPK1 is not essential for TNFR1-induced activation of NF-kappaB. Cell Death Differ 17:482–487

    PubMed  CAS  Google Scholar 

  • Wu CJ, Conze DB, Li T, Srinivasula SM, Ashwell JD (2006a) Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]. Nat Cell Biol 8:398–406

    PubMed  CAS  Google Scholar 

  • Wu ZH, Shi Y, Tibbetts RS, Miyamoto S (2006b) Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli. Science 311:1141–1146

    PubMed  CAS  Google Scholar 

  • Xu M, Skaug B, Zeng W, Chen ZJ (2009) A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta. Mol Cell 36:302–314

    PubMed Central  PubMed  CAS  Google Scholar 

  • Xu Y, Huang S, Liu ZG, Han J (2006a) Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation. J Biol Chem 281:8788–8795

    PubMed  CAS  Google Scholar 

  • Xu Y, Kim SO, Li Y, Han J (2006b) Autophagy contributes to caspase-independent macrophage cell death. J Biol Chem 281:19179–19187

    PubMed  CAS  Google Scholar 

  • Xu Y, Liu XD, Gong X, Eissa NT (2008) Signaling pathway of autophagy associated with innate immunity. Autophagy 4:110–112

    PubMed  CAS  Google Scholar 

  • Yang J, Lin Y, Guo Z, Cheng J, Huang J, Deng L, Liao W, Chen Z, Liu Z, Su B (2001) The essential role of MEKK3 in TNF-induced NF-kappaB activation. Nat Immunol 2:620–624

    PubMed  CAS  Google Scholar 

  • Yang Y, Xia F, Hermance N, Mabb A, Simonson S, Morrissey S, Gandhi P, Munson M, Miyamoto S, Kelliher MA (2011) A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage. Mol Cell Biol 31:2774–2786

    PubMed Central  PubMed  CAS  Google Scholar 

  • Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J (2009) RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 325:332–336

    PubMed  CAS  Google Scholar 

  • Zhang J, Zhang H, Li J, Rosenberg S, Zhang EC, Zhou X, Qin F, Farabaugh M (2011) RIP1-mediated regulation of lymphocyte survival and death responses. Immunol Res 51:227–236

    PubMed Central  PubMed  CAS  Google Scholar 

  • Zhang S, Lin Y, Kim YS, Hande MP, Liu ZG, Shen HM (2007) c-Jun N-terminal kinase mediates hydrogen peroxide-induced cell death via sustained poly(ADP-ribose) polymerase-1 activation. Cell Death Differ 14:1001–1010

    PubMed  CAS  Google Scholar 

  • Zhao J, Jitkaew S, Cai Z, Choksi S, Li Q, Luo J, Liu ZG (2012) Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis. Proc Natl Acad Sci U S A 109:5322–5327

    PubMed Central  PubMed  CAS  Google Scholar 

  • Zheng L, Bidere N, Staudt D, Cubre A, Orenstein J, Chan FK, Lenardo M (2006) Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1. Mol Cell Biol 26:3505–3513

    PubMed Central  PubMed  CAS  Google Scholar 

Download references

Acknowledgements

We apologize to researchers whose work was unable to be cited due to the space limit. The studies in my laboratory are supported by grants from NIEHS/NIH (R01ES017328) and the Department of Energy Low Dose Radiation Research Program (DE-SC0001173).

Author information

Authors and Affiliations

  1. Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest DR SE, Albuquerque, NM, 87108, USA

    Yong Lin M.D., Ph.D.

Authors
  1. Yong Lin M.D., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yong Lin M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Department of Physiology, National University of Singapore Yong Loo Lin School of Medicine, Singapore, Singapore

    Han-Ming Shen

  2. Department of Biomedical Molecular Biology (UGent), VIB/University of Ghent Inflammation Research Center (VIB), Zwijnaarde, Belgium

    Peter Vandenabeele

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Science+Business Media New York

About this chapter

Cite this chapter

Lin, Y. (2014). RIP1-Mediated Signaling Pathways in Cell Survival and Death Control. In: Shen, HM., Vandenabeele, P. (eds) Necrotic Cell Death. Cell Death in Biology and Diseases. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-8220-8_2

Download citation

Publish with us

Policies and ethics

Search

Navigation