Abstract
Several paradigms of necrotic cell death have been dissected genetically and molecularly in Caenorhabditis elegans over the past two decades. These studies have contributed significantly to our current understanding of necrosis. Similarly to other organisms, necrotic cell death in the nematode is manifested as the catastrophic collapse of cellular homeostasis, in response to overwhelming stress that is inflicted either in the form of extreme environmental stimuli or by intrinsic insults such as the expression of proteins carrying deleterious mutations. Remarkably, non-apoptotic cell death in C. elegans and pathological cell death in humans share multiple fundamental features and mechanistic aspects. Such commonalities indicate that similarly to apoptosis, necrotic cell death mechanisms are also conserved, between distant species, and render the worm a versatile tool, with the capacity to facilitate studies of human pathologies. In this chapter, we survey necrosis paradigms that have been characterized in the nematode and outline the cellular and molecular mechanisms implicated in mediating cell demise. In addition, we discuss experimental approaches that utilize C. elegans to elucidate the molecular underpinnings of devastating human disorders that entail necrosis.
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Work in the authors’ laboratory is funded by grants from the European Research Council (ERC), the European Commission Framework Programmes, and the Greek Ministry of Education. Vassiliki Nikoletopoulou is supported by an EMBO long-term postdoctoral fellowship.
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Nikoletopoulou, V., Tavernarakis, N. (2014). Necrotic Cell Death in Caenorhabditis elegans . In: Shen, HM., Vandenabeele, P. (eds) Necrotic Cell Death. Cell Death in Biology and Diseases. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-8220-8_15
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