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Systemic Lupus Erythematosus and the Kidney

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Core Concepts in Parenchymal Kidney Disease

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Abstract

Lupus nephritis (LN) is an immune complex glomerulonephritis that affects about half of patients with systemic lupus erythematosus (SLE). Patients who develop LN in the setting of SLE have a worse prognosis overall and can develop chronic or end-stage kidney disease. Effective therapies have been developed to treat LN, and while outcomes are better than in the past, complete remissions are still difficult to achieve, and the immunosuppressive therapies commonly used are associated with significant morbidity and mortality. Consequently the LN community is actively working to develop more effective, less toxic novel LN therapies. These new therapeutics are being designed based on an increasing knowledge of the pathogenesis of SLE, and in particular LN, and are guided by the types of kidney injuries seen in LN. This chapter reviews the diagnosis and management of LN as currently practiced and the targets of future management strategies based on the pathogenesis and pathology of LN.

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Authors and Affiliations

  1. Ohio State University College of Medicine, Columbus, OH, USA

    Brad H. Rovin M.D., F.A.C.P., F.A.S.N.

  2. Department of Internal Medicine, Division of Nephrology, The Ohio State University, Columbus, OH, USA

    Daniel J. Birmingham Ph.D.

  3. Department of Pathology, The Ohio State University, Columbus, OH, USA

    Tibor Nadasdy M.D.

Authors
  1. Brad H. Rovin M.D., F.A.C.P., F.A.S.N.
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  2. Daniel J. Birmingham Ph.D.
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  3. Tibor Nadasdy M.D.
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Correspondence to Brad H. Rovin M.D., F.A.C.P., F.A.S.N. .

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Editors and Affiliations

  1. Div. Nephrology & Hypertension, Mayo Clinic Dept. Internal Medicine, Rochester, Minnesota, USA

    Fernando C. Fervenza

  2. Renal Division, Brigham and Women's Hospital, Boston, Massachusetts, USA

    Julie Lin

  3. Mayo Clinic, Rochester, Minnesota, USA

    Sanjeev Sethi

  4. Renal Division, Brigham and Women's Hospital Harvard Medical School, Boston, Massachusetts, USA

    Ajay K. Singh

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Rovin, B.H., Birmingham, D.J., Nadasdy, T. (2014). Systemic Lupus Erythematosus and the Kidney. In: Fervenza, F., Lin, J., Sethi, S., Singh, A. (eds) Core Concepts in Parenchymal Kidney Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8166-9_11

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  • DOI: https://doi.org/10.1007/978-1-4614-8166-9_11

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