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Microfluidics for Neuronal Imaging

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Neural Computation, Neural Devices, and Neural Prosthesis

Abstract

In neurobiology studies, the use of well-controllable microenvironments that can actively interact with biological samples is becoming increasingly popular. Microfluidic systems due to their precise micron-size dimensions are becoming the gold standard for manipulating small-model organisms in vivo, such as the nematode Caenorhabditis elegans and the fruitfly Drosophila melanogaster as well as for assembling and interacting with neuronal cell cultures in vitro. The reproducible microenvironment, the automation of time-consuming protocols, and the low manufacturing cost of microfluidic chips offer unique experimental capabilities and a large amount of high-quality data to the neurobiologist over traditional methods. This chapter highlights a certain aspect of microfluidic technology that facilitates the study of neuronal physiology and function through imaging.

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Authors and Affiliations

  1. Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA

    Daphne Bazopoulou

  2. Department of Biomedical Engineering and Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA

    Nikos Chronis

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  1. Daphne Bazopoulou
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  2. Nikos Chronis
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Correspondence to Nikos Chronis .

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  1. National University of Singapore, Singapore, Singapore

    Zhi Yang

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Bazopoulou, D., Chronis, N. (2014). Microfluidics for Neuronal Imaging. In: Yang, Z. (eds) Neural Computation, Neural Devices, and Neural Prosthesis. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8151-5_10

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