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Neuronal Arborizations, Spatial Innervation, and Emergent Network Connectivity

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The Computing Dendrite

Part of the book series: Springer Series in Computational Neuroscience ((NEUROSCI,volume 11))

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Abstract

Neurons innervate space by their axonal and dendritic arborizations. Synapses can form when axons and dendrites are in close proximity. The geometry of neurons and their numerical densities in space are thus primary factors in the formation of synaptic connectivity of neuronal networks. A simulator of neuronal morphology based on principles of neural development (NETMORPH) has been used to show that realistic network connectivities emerge from realistic neuronal morphologies and simple proximity-based synapse formation rules.

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Acknowledgments

This work was supported by grants from the Netherlands Organization for Scientific Research (NWO) through the Program Computational Life Sciences (grant number 635.100.005), the MC-RTN project NEURoVERS-it (grant number 019247) of the European Union, and the BIO-ICT project SECO (grant number 216593) of the Seventh Framework Programme of the European Union.

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Authors and Affiliations

  1. Computational Neuroscience Group, Department of Integrative Neurophysiology,, Center for Neurogenomics and Cognitive Research, VU University, Amsterdam, The Netherlands

    Jaap van Pelt & Arjen van Ooyen

  2. Department of Anatomy and Neuroscience, VU University Medical Center, Amsterdam, The Netherlands

    Harry B. M. Uylings

Authors
  1. Jaap van Pelt
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  2. Harry B. M. Uylings
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  3. Arjen van Ooyen
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Correspondence to Jaap van Pelt .

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Editors and Affiliations

  1. Institute of Clinical Neuroanatomy, Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society & Goethe-University, Frankfurt, Germany

    Hermann Cuntz

  2. Institute for Theoretical Biology, Humboldt-Universität zu Berlin, Berlin, Germany

    Michiel W.H. Remme

  3. Department of Neurobiology, Hebrew University of Jerusalem, Jerusalem, Israel

    Benjamin Torben-Nielsen

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van Pelt, J., Uylings, H.B.M., van Ooyen, A. (2014). Neuronal Arborizations, Spatial Innervation, and Emergent Network Connectivity. In: Cuntz, H., Remme, M., Torben-Nielsen, B. (eds) The Computing Dendrite. Springer Series in Computational Neuroscience, vol 11. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8094-5_4

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