The Adhesion Molecule Anosmin-1 in Neurology: Kallmann Syndrome and Beyond

  • Fernando de Castro
  • Pedro F. Esteban
  • Ana Bribián
  • Verónica Murcia-Belmonte
  • Diego García-González
  • Diego Clemente
Part of the Advances in Neurobiology book series (NEUROBIOL, volume 8)


Anosmin-1 is the glycoprotein encoded by the KAL1 gene and part of the extracellular matrix, which was first identified as defective in human Kallmann syndrome (KS, characterised by hypogonadotropic hypogonadism and anosmia); biochemically it is a cell adhesion protein. The meticulous biochemical dissection of the anosmin-1 domains has identified which domains are necessary for the protein to bind its different partners to display its biological effects. Research in the last decade has unravelled different roles of anosmin-1 during CNS development (axon pathfinding, axonal collateralisation, cell motility and migration), some of them intimately related with the cited KS but not only with this. More recently, anosmin-1 has been identified in other pathological scenarios both within (multiple sclerosis) and outside (cancer, atopic dermatitis) the CNS.


Heparan Sulphate Multiple Sclerosis Lesion Hypogonadotropic Hypogonadism Oligodendrocyte Precursor Cell Kallmann Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Our research is currently supported by grants from the Spanish Ministerio de Economía y Competitividad-MINECO (ADE10-0010, RD07-0060-2007, SAF2009-07842), and Fundación Eugenio Rodríguez Pascual (Spain) to FdC, Association pour la Recherche en Escleròse en Plaques-ARSEP (France) to DCL and FdC, and Gobierno de Castilla-La Mancha (PI2009/26 and PI2009/29,) to DCL and PFE, respectively. VMB is a PhD student who had a fellowship from Gobierno de Castilla-La Mancha (MOV2007-JI/19) and is currently hired under RD07-0060-2007. DGG is a PhD student who had a fellowship from Gobierno de Gastilla-La Mancha (PI2007-66) and is currently hired by SESCAM. DCL, FdCS and PFE are hired by SESCAM. ABA is the recipient of a Sara Borrell contract from the Spanish Ministerio de Economía y Competitividad-MINECO.

Compliance with Ethics Requirements

The authors declare that they have no conflicts of interest.


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© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Fernando de Castro
    • 1
  • Pedro F. Esteban
    • 1
  • Ana Bribián
    • 1
    • 2
  • Verónica Murcia-Belmonte
    • 1
  • Diego García-González
    • 1
  • Diego Clemente
    • 1
  1. 1.Grupo de Neurobiología del Desarrollo-GNDe, Hospital Nacional de Parapléjicos-SESCAMToledoSpain
  2. 2.Institute of Bioengineering of Catalonia, Parc Cientific de Barcelona and Cell Biology DepartmentUniversidad de BarcelonaBarcelonaSpain

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