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Epigenetics and Complex Traits pp 179–207Cite as

Impact of the Early-Life Environment on the Epigenome and Behavioral Development

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Abstract

The environment in which we live, and especially the early-life environment, regulates our behavioral development. Adversity during early life is strongly associated with problems in behavioral regulation and psychopathology in adulthood. Until recently, the mechanisms responsible for behavioral changes induced by early-life adversity were not clear. However, recent evidence suggests that early-life environment induces behavioral changes through epigenetic mechanisms controlling the expression of genes involved in the regulation of behavior. Thus, the epigenome mediates the effects of environmental variability on behavioral, physiological, and pathological responses increasing vulnerability toward suicidal behaviors. Numerous findings in animals and humans support this view. This chapter reviews the evidence suggesting that epigenetic changes are induced by the early environment and impact the regulation of gene expression in the brain increasing the risk for suicidal behaviors.

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  1. McGill Group for Suicide Studies, Department of Psychiatry, Douglas Mental Health Institute, 6875 LaSalle Blvd, Montreal, QC, Canada, H4H 1R3

    Benoit Labonté & Gustavo Turecki M.D., Ph.D.

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  1. Benoit Labonté
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  2. Gustavo Turecki M.D., Ph.D.
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Correspondence to Gustavo Turecki M.D., Ph.D. .

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  1. Departments of Obstetrics and Gynecology and Human Genetics, McGill University, Montreal, Canada

    Anna K. Naumova

  2. Lady Davis Institute for Medical Research Centre for Clinical Epidemiology, Jewish General Hospital, Montreal, Canada

    Celia M.T. Greenwood

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Labonté, B., Turecki, G. (2013). Impact of the Early-Life Environment on the Epigenome and Behavioral Development. In: Naumova, A., Greenwood, C. (eds) Epigenetics and Complex Traits. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8078-5_8

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