Abstract
It has been recently found that the human white adipose tissue (WAT), similarly to neoplasia, shows in vivo a robust angiogenic switch when the growth rate exceeds a given expansion threshold. When compared to the bone marrow (BM), human WAT contains significantly more CD45−CD34+ progenitors that express high levels of angiogenesis-related genes and can generate in culture endothelial cells and tubes as efficiently as mesenchymal cells. We recently reported that human WAT CD45−CD34+ progenitors obtained from lipotransfer procedures contributed to tumor vascularization and significantly increased tumor growth and metastases in several orthotopic models of human breast cancer. In another recent study, 321 consecutive patients operated for primary breast cancer who subsequently underwent a lipotransfer procedure were compared with two matched patients with similar characteristics who did not undergo lipotransfer. In this retrospective study, the lipotransfer group exhibited a higher risk of local events compared to the controls. A second data revision after prolonged follow-up confirmed this significant difference. It seems urgent to clarify which WAT cell populations can be used safely for tissue/organ reconstruction in cancer patients and what have the potential for reactivating dormant tumor cells.
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Agliano A, Martin-Padura I, Marighetti P, et al. Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains. Int J Cancer. 2008;123:2222–7.
Bertolini F, Mancuso P, Braidotti P, Shaked Y, Kerbel RS. The multiple personality disorder phenotype(s) of circulating endothelial cells in cancer. Biochim Biophys Acta. 2009;1796:27–32.
Corada M, Liao F, Lindgren M, et al. Monoclonal antibodies directed to different regions of vascular endothelial cadherin extracellular domain affect adhesion and clustering of the protein and modulate endothelial permeability. Blood. 2001;97:1679–84.
Gallo M, De Luca A, Lamura L, Normanno N. Zoledronic acid blocks the interaction between mesenchymal stem cells and breast cancer cells: Implications for the adjuvant therapy of breast cancer. Ann Oncol. 2012;23:597–604.
Grenier G, Scimè A, Le Grand F, et al. Resident endothelial precursors in muscle, adipose, and dermis contribute to postnatal vasculogenesis. Stem Cells. 2007;25:3101–10.
Hirschi KK, Ingram DA, Yoder MC. Assessing identity, phenotype, and fate of endothelial progenitor cells. Arterioscler Thromb Vasc Biol. 2008;28:1584–95.
Lohsiriwat V, Curigliano G, Rietjens M, Goldhirsch A, Petit YV. Autologous fat transplantation in patients with breast cancer: “silencing” or “fueling” cancer recurrence? Breast. 2011;20:351–7.
Mancuso P, Antoniotti P, Quarna J, et al. Validation of a standardized method for enumerating circulating endothelial cells and progenitors: flow cytometry and molecular and ultrastructural analyses. Clin Cancer Res. 2009;15:267–73.
Mancuso P, Martin-Padura I, Calleri A, et al. Circulating perivascular progenitors, a target of PDGFR inhibition. Int J Cancer. 2011;129:1344–50.
Martin-Padura I, Gregato G, Marighetti P, et al. The white adipose tissue used in lipotransfer procedures is a rich reservoir of CD34+ progenitors able to promote cancer progression. Cancer Res. 2012;72(1):325–34. Epub 2011 Nov 3.
Petit JY, Clough K, Sarfati I, et al. Lipotransfer in cancer patients: from surgical technique to oncologic point of view. Plast Reconstr Surg. 2010;126:262–3.
Petit JY, Botteri E, Lohsiriwat V, et al. Locoregional recurrence risk after lipotransfer in breast cancer patients. Ann Oncol. 2012;23:582–8.
Petit JY, Rietjens M, Botteri E, et al. Evaluation of fat grafting safety in patients with intra epithelial neoplasia: a matched-cohort study. Ann Oncol. 2013;24:1479–84.
Purhonen S, Palm J, Rossi D, et al. Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth. Proc Natl Acad Sci U S A. 2008;105:6620–5.
Rabascio C, Muratori E, Mancuso P, et al. Assessing tumor angiogenesis: increased circulating VE-cadherin RNA in patients with cancer indicates viability of circulating endothelial cells. Cancer Res. 2004;15:4373–7.
Sengenès C, Lolmède K, Zakaroff-Girard A, et al. Preadipocytes in the human subcutaneous adipose tissue display distinct features from the adult mesenchymal and hematopoietic stem cells. J Cell Physiol. 2005;205:114–22.
Shultz LD, Ishikawa F, Greiner DL. Humanized mice in translational biomedical research. Nat Rev Immunol. 2007;7:118–30.
Yoder MC, Ingram DA. The definition of EPCs and other bone marrow cells contributing to neoangiogenesis and tumor growth: is there common ground for understanding the roles of numerous marrow-derived cells in the neoangiogenic process? Biochim Biophys Acta. 2009;1796:50–4.
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Mancuso, P., Martin-Padura, I., Bertolini, F. (2013). Adipose-Derived Endothelial Precursor Cells Supporting Tumor Growth. In: Cao, Y. (eds) Angiogenesis in Adipose Tissue. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8069-3_16
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DOI: https://doi.org/10.1007/978-1-4614-8069-3_16
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