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Adipose Tissue-Derived Progenitor Cells and Cancer

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Angiogenesis in Adipose Tissue

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Abstract

Obesity, a condition of white adipose tissue (WAT) overgrowth and perturbation of system metabolic homeostasis, is a significant risk factor for cancer mortality. The mechanisms underlying the obesity-cancer link remain poorly understood. Elevated systemic circulation of pathogenic adipokines and chronic low-grade inflammation associated with obesity have indicated a potential tumor-promoting role of endocrine WAT signaling. In addition, possible effects of WAT-derived cell populations localized at the tumor site have been uncovered. Recent studies have shown that adipose stromal cell (ASC), the progenitors of adipocytes, can traffic to tumors. As a constituent of tumor microenvironment, ASC may engage in paracrine signaling and thereby promote cancer progression. Here, we discuss tumor-promoting functions of ASC and a potential of targeting these cells as an approach to thwarting cancer progression.

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Authors and Affiliations

  1. Institute of Molecular Medicine, Center for Stem Cell and Regenerative Medicine, The University of Texas Health Science Center, 1825 Pressler St., Rm 630G, Houston, TX, 77030, USA

    Chieh Tseng & Mikhail G. Kolonin Ph.D.

  2. The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, 1825 Pressler St., Rm 630G, Houston, TX, 77030, USA

    Chieh Tseng & Mikhail G. Kolonin Ph.D.

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  1. Chieh Tseng
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Correspondence to Mikhail G. Kolonin Ph.D. .

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  1. Microbiology, Tumor and Cell biology (MT, Karolinska Institutet, Stockholm, Sweden

    Yihai Cao

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Tseng, C., Kolonin, M.G. (2013). Adipose Tissue-Derived Progenitor Cells and Cancer. In: Cao, Y. (eds) Angiogenesis in Adipose Tissue. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8069-3_15

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