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Myogenic Potential of Stem Cells: In Vivo Assessment

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Stem Cells: Current Challenges and New Directions

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Stem cell therapy has been envisaged for treating disorders affecting skeletal muscle tissue. Several cell types have been identified for exerting a myogenic potential in certain conditions. In order to efficiently regenerate injured muscles while remaining safe for patients, these myogenic progenitors should present characteristics such as their availability to be isolated from patients, their growth and commitment performances and, if necessary, their capacity to be genetically corrected. Here, we present an overview of the main myogenic cell candidates that have been identified and tested in vivo, classifying them by their route of delivery (intra-muscular and systemic delivery), and focusing our attention on their regenerative capacity in animal models of Duchenne muscular dystrophy.

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Acknowledgements

The research conducted by the authors in the field of cell transplantation is supported by Association Française contre les Myopathies (AFM) and Association Institut de Myologie (AIM), Université Pierre et Marie Curie (UPMC), INSERM, CNRS, PHRC, ANR Genopath In-A-Fib, DPP-Nl and EC contract MYOAGE (contract HEALTH-F2-2009-223576) from the seventh FP.

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Authors and Affiliations

  1. Institut de Myologie, UM76, Université Pierre et Marie Curie, Paris, France

    Maximilien Bencze, Gillian S. Butler-Browne & Vincent Mouly

  2. UMR 7215, CNRS, Paris, France

    Maximilien Bencze, Gillian S. Butler-Browne & Vincent Mouly

  3. INSERM, U974, Institut de Myologie, Paris, France

    Maximilien Bencze, Gillian S. Butler-Browne & Vincent Mouly

  4. Laboratory on Thymus Research, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil

    Ingo Riederer & Wilson Savino

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  1. Maximilien Bencze
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  2. Ingo Riederer
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  3. Gillian S. Butler-Browne
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  4. Wilson Savino
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  5. Vincent Mouly
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Correspondence to Vincent Mouly .

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  1. Regenerative Medicine Program, Ottawa Hospital Research Institute Sprott Centre for Stem Cell Research, Ottawa, Ontario, Canada

    Kursad Turksen

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© 2013 Springer Science+Business Media New York

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Bencze, M., Riederer, I., Butler-Browne, G.S., Savino, W., Mouly, V. (2013). Myogenic Potential of Stem Cells: In Vivo Assessment. In: Turksen, K. (eds) Stem Cells: Current Challenges and New Directions. Stem Cell Biology and Regenerative Medicine. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-8066-2_1

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